血清胱抑素C在诊断足月新生儿高胆红素血症相关急性肾损伤中的作用

钱力; 程锐; 王崇伟; 陈秋霞; 张爱华

doi:10.16016/j.1000-5404.201709195

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血清胱抑素C在诊断足月新生儿高胆红素血症相关急性肾损伤中的作用

临床医学 | 更新时间：2026-01-09

- 血清胱抑素C在诊断足月新生儿高胆红素血症相关急性肾损伤中的作用
- Clinical value of serum cystatin C in diagnosis of acute kidney injury associated with hyperbilirubinemia in full-term newborns
- 第三军医大学学报 2018年40卷第2期页码：165-168
- 作者机构：
  
  1.210008南京，南京医科大学附属儿童医院：新生儿医疗中心
  2.210008南京，南京医科大学附属儿童医院：肾脏科
- 作者简介：
  
  [ 张爱华，E-mail: zhaihua@njmu.edu.cn ZHANG Aihua, zhaihua@njmu.edu.cn
- 基金信息：
  
  江苏省自然科学基金(BK2011105)
- DOI：10.16016/j.1000-5404.201709195
  中图分类号： R446.112;R722.17;R726.92
- 收稿：2017-09-27，
  
  修回：2017-11-03，
  
  纸质出版：2018-01-30
- 稿件说明：
移动端阅览
钱力, 程锐, 王崇伟, 等. 血清胱抑素C在诊断足月新生儿高胆红素血症相关急性肾损伤中的作用[J]. 第三军医大学学报, 2018,40(2):165-168.

Li QIAN, Rui CHENG, Chongwei WANG, et al. Clinical value of serum cystatin C in diagnosis of acute kidney injury associated with hyperbilirubinemia in full-term newborns[J]. Journal of Third Military Medical University, 2018, 40(2): 165-168.
钱力, 程锐, 王崇伟, 等. 血清胱抑素C在诊断足月新生儿高胆红素血症相关急性肾损伤中的作用[J]. 第三军医大学学报, 2018,40(2):165-168. DOI： 10.16016/j.1000-5404.201709195.

Li QIAN, Rui CHENG, Chongwei WANG, et al. Clinical value of serum cystatin C in diagnosis of acute kidney injury associated with hyperbilirubinemia in full-term newborns[J]. Journal of Third Military Medical University, 2018, 40(2): 165-168. DOI： 10.16016/j.1000-5404.201709195.

摘要

目的

探讨血清胱抑素C (serum cystatin C

CysC)在诊断足月新生儿高胆红素血症相关急性肾损伤(acute renal injury

AKI)中的作用。

方法

选择2015年6月至2016年6月在本院诊治的217例高胆红素血症的足月儿为研究对象，根据是否发生AKI分为非AKI病例组171例和AKI病例组46例，同期住院的健康足月儿52例为对照组。

结果

对照组、非AKI病例组和AKI病例组的尿素氮、总蛋白、白蛋白和前白蛋白比较，差异无统计学意义(

0.05)。与对照组比，非AKI病例组和AKI病例组的总胆红素、CysC、视黄醇结合蛋白和胆固醇有差异(

0.05)。与非AKI病例组比，AKI病例组的CysC差异，有统计学意义(

0.05)。CysC预测AKI的ROC曲线最佳临界值为2.17 mg/L，AUC为0.845，95%置信区间下限0.733，上限0.956，

=0.000，敏感度82.6%(38/46)，特异度70.9%(158/223)。

结论

通过血清CysC的检测可以早期发现新生儿高胆红素血症相关AKI。

Abstract

Objective

To study the value of serum cystatin C (CysC) in the diagnosis of acute kidney injury (AKI) associated with hyperbilirubinemia in full-term newborns.

Methods

A total of 217 full-term neonates with hyperbilirubinemia admitted in the Children's Hospital Affiliated to Nanjing Medical University over the period from June

2015 to June

2016 were enrolled in this study

including 46 with AKI and 171 without AKI. Another 52 healthy neonates were enrolled to serve as the normal control group.

Results

There were no significant differences in the levels of urea nitrogen

total protein

albumin or prealbumin among the 3 groups (

0.05). Compared with the normal control group

the neonates with hyperbilirubinemia had significantly elevated levels of total bilirubin

CysC

retinol binding protein and cholesterol (

0.05). The neonates with AKI showed significantly higher levels of CysC than those without AKI (

0.05). The optimal cutoff value of CysC for predicting AKI was 2.17 mg/L with an AUC of 0.845 (95%

: 0.733~0.956

=0.000); at this cutoff value

CysC had a sensitivity of 82.6% (38/46) and a specificity of 70.9% (158/223) in predicting AKI in the neonates with hyperbilirubinemia.

Conclusion

Serum CysC can be used as an indicator for early detection of AKI associated with hyperbilirubinemia in neonates.

关键词

Keywords

references

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