504例胃息肉发生相关因素的调查研究

何金龙; 陈磊; 代剑华; 张昊翔; 冯吉; 魏周玲; 房殿春

doi:10.16016/j.1000-5404.201708111

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504例胃息肉发生相关因素的调查研究

临床医学 | 更新时间：2026-01-09

- 504例胃息肉发生相关因素的调查研究
- Factors associated with the occurrence of gastric polyps: a case-control study of 504 pairs
- 第三军医大学学报 2017年39卷第22期页码：2226-2231
- 作者机构：
  
  400038 重庆，第三军医大学西南医院全军消化病研究所
- 作者简介：
  
  [ 房殿春, E-mail: fangdianchun@hotmail.com FANG Dianchun, E-mail: fangdianchun@hotmail.com
- 基金信息：
- DOI：10.16016/j.1000-5404.201708111
  中图分类号： R195.4; R573; R735.2
- 收稿：2017-08-18，
  
  修回：2017-09-05，
  
  纸质出版：2017-11-30
- 稿件说明：
移动端阅览
何金龙, 陈磊, 代剑华, 等. 504例胃息肉发生相关因素的调查研究[J]. 第三军医大学学报, 2017,39(22):2226-2231.

Jinlong HE, Lei CHEN, Jianhua DAI, et al. Factors associated with the occurrence of gastric polyps: a case-control study of 504 pairs[J]. Journal of Third Military Medical University, 2017, 39(22): 2226-2231.
何金龙, 陈磊, 代剑华, 等. 504例胃息肉发生相关因素的调查研究[J]. 第三军医大学学报, 2017,39(22):2226-2231. DOI： 10.16016/j.1000-5404.201708111.

Jinlong HE, Lei CHEN, Jianhua DAI, et al. Factors associated with the occurrence of gastric polyps: a case-control study of 504 pairs[J]. Journal of Third Military Medical University, 2017, 39(22): 2226-2231. DOI： 10.16016/j.1000-5404.201708111.

摘要

目的

探讨胃息肉发生的相关因素，为更有针对性胃息肉的预防提供科学依据。

方法

收集2016年10月至2017年3月就诊于西南医院各科室的504例行胃镜检查并经病理学证实为胃息肉的患者，以同期健康体检和各科室就诊的504例行胃镜检查未发现胃息肉者作为对照，使用统一设计的调查问卷进行相关因素调查。对调查各因素进行单因素分析，将筛选出有统计学意义的因素纳入多因素Logistic回归分析。

结果

单因素分析结果显示，质子泵抑制剂使用情况、

H.pylori

感染史、胃息肉家族史、吸烟、饮酒、喝茶、体育锻炼、进食速度、进食水果、心情状况、精神创伤史及工作生活压力可能与胃

息肉发生相关。多因素Logistic回归分析结果显示，使用质子泵抑制剂、

H.pylori

感染史、胃息肉家族史、长期饮酒、进食速度较快、精神创伤史是胃息肉发生的危险因素，体育锻炼(≥1次/周)、进食水果(≥2次/周)为其保护因素。

结论

胃息肉的发生与多种因素相关，避免长时间使用质子泵抑制剂及长期饮酒、根除

H.pylori

感染、适当的体育锻炼与进食水果、保持乐观的心态和养成良好的饮食习惯可能会有效降低胃息肉的发生风险。

Abstract

Objective

To investigate the factors associated with the occurrence of gastric polyps to provide evidence for devising strategies for its prevention.

Methods

We retrospectively analyzed 504 cases of gastric polyps diagnosed by gastric endoscopy and subsequent pathological examination from different departments of the Southwest Hospital between October 2016 and March 2017. We also enrolled 504 subjects without gastric polyps during the same period to serve as the control group and paired them with the case group at a 1: 1 ratio. The relevant data were collected from all the participants using a self-designed questionnaire. The factors associated with the occurrence of gastric polyps were analyzed with

Chi

-square test followed by multivariate logistic regression analysis.

Results

Univariate analysis showed that a history of using proton-pump inhibitors (PPIs)

a history of

H. pylori

infection

a family history of gastric polyps

smoking

drinking alcohol

drinking tea

physical exercise

eating speed

fruit intake

emotional status

psychological trauma and pressure from work and daily life were all potential factors related to the occurrence of gastric polyps. Multivariate logistic regression analysis identified a history of using PPIs

a history of

H.pylori

infection

a family history of gastric polyps

long-term alcohol drinking

eating fast and psychological trauma as the risk factors and physical exercise (not less than once a week) and eating fruits (not less than twice a week) as the protective factors against the o

ccurrence of gastric polyps.

Conclusion

Multiple factors contribute to the occurrence of gastric polyps. Avoiding long-term use of PPIs and drinking alcohol

eradication of

H.pylori

infection

active exercise

sufficient fruit intake

a positive attitude and a good eating habit may effectively reduce the risk of gastric polyps.

关键词

Keywords

references

CARMACK S W, GENTA R M, SCHULER C M, et al . The current spectrum of gastric polyps: a 1-year national study of over 120, 000 patients[J ] . Am J Gastroenterol, 2009, 104(6): 1524-1532. DOI:10.1038/ajg.2009.139.

MORAIS D J, YAMANAKA A, ZEITUNE J M, et al . Gastric polyps: a retrospective analysis of 26, 000 digestive endoscopies[J ] . Arq Gastroenterol, 2007, 44(1): 14-17. DOI:10.1590/s0004-28032007000100004.

FAN N N, YANG J, SUN G, et al . Changes in the spectrum of gastric polyps in the Chinese population[J ] . World J Gastroenterol, 2015, 21(33): 9758-9764. DOI: 10.3748/wjg.v21.i33.9758.

郑炜, 夏志伟, 金珠, 等.良性胃息肉检出率变化及临床特点分析[J].中国微创外科杂志, 2014, 14(8): 686-691. DOI: 10.3969/j.issn.1009-6604.2014.08.005.

ZHENG W, XIA Z W, JIN Z, et al . Detection rates of benign gastric polyps and their clinical characteristics[J ] . Chin J Minim Inva Surg, 2014, 14(8): 686-691. DOI: 10.3969/j.issn.1009-6604.2014.08.005.j.issn.1009-6604.2014.08.005.

ELHANAFI S, SAADI M, LOU W, et al . Gastric polyps: association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study[J ] . World J Gastrointest Endosc, 2015, 7(10): 995-1002. DOI: 10.4253/wjge.v7.i10.995..

李超, 崔立红, 王晓辉, 等.大肠息肉的危险因素分析[J].现代生物医学进展, 2014, 14(24): 4681-4685. DOI: 10.13241/j.cnki.pmb.2014.24.019.

LI C, CUI L H, WANG X H, et al .Analysis of the risk factors of colorectal polyps[J ] . Progr Mod Biomed, 2014, 14(24):4681-4685. DOI: 10.13241/j.cnki.pmb.2014.24.019.

吴乾龙, 曹杰, 王成兴, 等.广州地区年轻胃癌发病危险因素的病例对照研究[J].中国普通外科杂志, 2015, 24(4): 570-574. DOI: 10.3978/j.issn.1005-6947.2015.04.020.

WU Q L, CAO J, WANG C X, et al . Risk factors for gastric cancer in young people in Guangzhou area: a case-control study[J ] . Chin J Gen Surg, 2015, 24(4): 570-574. DOI: 10.3978/j.issn.1005-6947.2015.04.020.

蒋绚, 张庆文, 张振宇, 等.长期应用质子泵抑制剂的风险观察[J].中华医学杂志, 2014, 94(4): 284-288. DOI: 10. 3760/cma.j.issn.0376-2491.2014.04.012.

JIANG X, ZHANG Q W, ZHANG Z Y, et al . The risks of long-term proton pump inhibitors use[J ] . Natl Med J China, 2014, 94(4): 284-288. DOI: 10.3760/cma.j.issn. 0376-2491.2014.04.012.

THOMSON A B, SAUVE M D, KASSAM N, et al . Safety of the long-term use of proton pump inhibitors[J ] . World J Gastroenterol, 2010, 16(19): 2323-2330. DOI: 10.3748/wjg.v16.i19.2323.

黄旭慧, 卜一珊, 阳丽梅, 等.内科住院患者质子泵抑制剂使用情况的调查分析[J].中国新药与临床杂志, 2014, 33(1): 71-74.

HUANG X H, PU Y S, YANG L M, et al . Investigation of use of proton pump inhibitors in medical inpatients[J ] . Chin J New Drugs Clin Rem, 2014, 33(1): 71-74.

ITO T, JENSEN R T. Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron, and magnesium[J]. Curr Gastroenterol Rep, 2010, 12(6): 448-457. DOI: 10.1007/s11894-010-0141-0.

MARTIN F C, CHENEVIX-TRENCH G, YEOMANS N D. Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors[J]. Aliment Pharmacol Ther, 2016, 44(9): 915-925. DOI: 10.1111/apt.13800.

TRAN-DUY A, SPAETGENS B, HOES A W, et al . Use of proton pump inhibitors and risks of fundic gland polyps and gastric cancer: systematic review and meta-analysis[J ] . Clin Gastroenterol Hepatol, 2016, 14(12): 1706-1719.e5. DOI: 10.1016/j.cgh.2016.05.018.

VIETH M, STOLTE M. Fundic gland polyps are not induced by proton pump inhibitor therapy[J]. Am J Clin Pathol, 2001, 116(5): 716-720. DOI: 10.1309/XFWR-LXA7-7TK1-N3Q8.

HUANG C Z, LAI R X, MAI L, et al . Relative risk factors associated with the development of fundic gland polyps[J ] . Eur J Gastroenterol Hepatol, 2014, 26(11): 1217-1221. DOI: 10.1097/meg.0000000000000199.

CAO H, QU R, ZHANG Z, et al . Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China[J ] . Chin Med J, 2014, 127(7): 1239-1243.

LJUBICIć N, BANIć M, KUJUNDZIć M, et al . The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps[J ] . Eur J Gastroenterol Hepatol, 1999, 11(7): 727-730. DOI: 10.1097/00042737-199907000-00008..

WATANABE N, SENO H, NAKAJIMA T, et al . Regression of fundic gland polyps following acquisition of Helicobacter pylori [J ] . Gut, 2002, 51(5): 742-745. DOI: 10.1136/gut.51.5.742..

HASSAN A, YERIAN L M, KUAN S F, et al . Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps[J ] . Hum Pathol, 2004, 35(3): 328-334. DOI: 10.1016/j.humpath.2003.10.010.

JAIN R, CHETTY R. Gastric hyperplastic polyps: a review[J]. Dig Dis Sci, 2009, 54(9): 1839-1846. DOI: 10. 1007/s10620-008-0572-8.

PARK D Y, LAUWERS G Y. Gastric polyps: classification and management[J]. Arch Pathol Lab Med, 2008, 132(4):633-640. DOI: 10.1043/1543-2165(2008)132 2.0.CO; 2.

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