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低氧环境下慢性充血性心力衰竭患者脂肪因子水平变化对心室构型的影响
Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition
- 第三军医大学学报 2017年39卷第23期 页码：2299-2302
- 作者机构：
1.810016 西宁，青海大学研究生院临床医学系
2.810007 西宁，青海省人民医院干部保健科
- 作者简介：
[郗爱旗，E-mail：13519786606@163.com XI Aiqi, E-mail: 13519786606@163.com
- 基金信息：青海省科技计划项目(2013-T-Y30)
DOI：10.16016/j.1000-5404.201708045
中图分类号： R339.54;R363.21;R541.6收稿：2017-08-08，
修回：2017-09-28，
纸质出版：2017-12-15
- 稿件说明：
移动端阅览
梅艳, 郗爱旗, 廖宝霞, 等. 低氧环境下慢性充血性心力衰竭患者脂肪因子水平变化对心室构型的影响[J]. 第三军医大学学报, 2017,39(23):2299-2302.
Yan MEI, Aiqi XI, Baoxia LIAO, et al. Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition[J]. Journal of Third Military Medical University, 2017, 39(23): 2299-2302.
梅艳, 郗爱旗, 廖宝霞, 等. 低氧环境下慢性充血性心力衰竭患者脂肪因子水平变化对心室构型的影响[J]. 第三军医大学学报, 2017,39(23):2299-2302. DOI： 10.16016/j.1000-5404.201708045.
Yan MEI, Aiqi XI, Baoxia LIAO, et al. Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition[J]. Journal of Third Military Medical University, 2017, 39(23): 2299-2302. DOI： 10.16016/j.1000-5404.201708045.
摘要
目的
2
观察低氧环境下慢性心力衰竭(chronic heart faiture
CHF)患者脂肪因子趋化素(chemerin)、瘦素(leptin)、脂联素(adiponectin)水平的变化及对心室构型的影响。
方法
2
选择收住我科按美国纽约心脏病协会心功能分级标准确诊的CHF患者，按生活的海拔区分为2 260 m组CHF患者、健康对照组各67例和3 300 m组CHF患者、对照组各62例。检测血浆脂联素、趋化素、瘦素水平，计算平均室壁应力(mean wall stress，MWS)和心室质量指数(left ventricular mass index，LVMI)。
结果
2
海拔3 300 m组CHF患者和健康对照组脂联素、趋化素、瘦素水平和MWS、LVMI均高于2 260 m组(
P
<
0.01)；同一海拔高度CHF患者脂联素、趋化素、瘦素水平和MWS、LVMI高于健康对照组；MWS和LVMI与脂联素、趋化素、瘦素水平均呈正相关(
P
<
0.01)。
结论
2
低氧环境下CHF患者脂肪因子脂联素、趋化素、瘦素水平的变化参与了CHF发生、发展的病理生理过程。
Abstract
Objective
2
To observe the changes of chemerin
leptin
adiponectin levels in chronic heart failure (CHF) patients living in hypoxic regions and investigate their effect on ventricular remodeling.
Methods
2
Totally 129 CHF patients diagnosed by the New York Heart Association (NYHA) criteria admitted to our department from May 2013 to December 2015 were enrolled in this study. According to the altitude they resided
they were divided into
the 2 260 meters group (
n
=67) and the 3 300 meters group (
n
=62). Another 67 and 62 healthy individuals who were residents of similar altitudes respectively served as normal control. The levels of plasma chemerin
leptin
and adiponectin were measured
and the mean wall stress (MWS) and left ventricular mass index (LVMI) were calculated.
Results
2
The levels of chemerin
leptin
adiponectin
MWS and LVMI were significantly higher in the healthy individuals and CHF patients at 3 300 meters than those at 2 260 meters above sea level (
P
<
0.01). The above indicators were also obviously higher in the CHF patients than the healthy subjects living at the same regions. Chemerin
leptin and adiponectin levels were positively correlated with MWS and LVMI (
P
<
0.01).
Conclusions
2
Adipokines chemerin
leptin and adiponectin take part in the pathogenesis of CHF in the patients living in hypoxic regions.
关键词
Keywords
references
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