孤立性侧脑室后角旁白质疏松对认知功能的影响及其神经心理特征

黄梅; 段炜; 成戎川; 郑健

doi:10.16016/j.1000-5404.201702098

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孤立性侧脑室后角旁白质疏松对认知功能的影响及其神经心理特征

临床医学 | 更新时间：2026-01-09

- 孤立性侧脑室后角旁白质疏松对认知功能的影响及其神经心理特征
- Neuropsychological characteristics of cognitive impairments associated with occipital periventricular leukoaraiosis
- 第三军医大学学报 2017年39卷第12期页码：1262-1267
- 作者机构：
  
  400037 重庆，第三军医大学新桥医院神经内科
- 作者简介：
  
  [郑健，E-mail:doctorzhengj@163.comZhengJian, E-mail:doctorzhengj@163.com
- 基金信息：
  
  中央军委保健委专项课题(14BJZ52);第三军医大学新桥医院临床科研项目(2015YLC14)
- DOI：10.16016/j.1000-5404.201702098
  中图分类号： R338.64;R395.2;R742.02
- 收稿：2017-02-20，
  
  修回：2017-03-08，
  
  纸质出版：2017-06-30
- 稿件说明：
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黄梅, 段炜, 成戎川, 等. 孤立性侧脑室后角旁白质疏松对认知功能的影响及其神经心理特征[J]. 第三军医大学学报, 2017,39(12):1262-1267.

Mei Huang, Wei Duan, Rongchuan Cheng, et al. Neuropsychological characteristics of cognitive impairments associated with occipital periventricular leukoaraiosis[J]. Journal of Third Military Medical University, 2017, 39(12): 1262-1267.
黄梅, 段炜, 成戎川, 等. 孤立性侧脑室后角旁白质疏松对认知功能的影响及其神经心理特征[J]. 第三军医大学学报, 2017,39(12):1262-1267. DOI： 10.16016/j.1000-5404.201702098.

Mei Huang, Wei Duan, Rongchuan Cheng, et al. Neuropsychological characteristics of cognitive impairments associated with occipital periventricular leukoaraiosis[J]. Journal of Third Military Medical University, 2017, 39(12): 1262-1267. DOI： 10.16016/j.1000-5404.201702098.

摘要

目的

探讨孤立性侧脑室后角旁白质疏松对认知功能的影响及其神经心理特征。

方法

纳入30例孤立性侧脑室后角旁白质疏松(后角组)、32例大脑半球多部位白质疏松(混合组)以及33例颅脑MRI证实无脑实质结构性改变的受试者(对照组)，采用简易精神状态量表(mini-mental state examination scale

MMSE)和蒙特利尔认知评估量表(Montreal cognitive assessment，MoCA

北京版)

评价受试者总体认知功能，韦氏成人智力量表中数字广度测验分项目评估注意能力，临床记忆量表评估记忆能力，对比分析侧脑室后角旁白质疏松所致认知损害特征。

结果

与对照组比较，后角组MMSE和MoCA总分较低(

0.01)，定向力、短时记忆、延迟记忆、指向记忆和语言测试单项评分也明显降低(

0.05，

0.01)，而其他认知方面单项评分差异无统计学意义(

＞0.05)；混合组MMSE和MoCA总分较低(

0.01)，定向力、记忆力、注意能力、视觉空间与执行、语言测试和抽象认知单项评分也明显降低(

0.05，

0.01)。

结论

孤立性侧脑室后角旁白质疏松导致以定向力、记忆力和语言能力减退为特征的认知功能损害。

Abstract

Objective

To explore the effect of isolated occipital periventricular leukoaraiosis on cognitive function and the neuropsychological characteristics of the patients.

Methods

Thirty patients with isolated occipital periventricular leukoaraiosis (occipital periventricular group)

32 patients with leukoaraiosis at multiple sites in the cerebral hemisphere (mixed group) and 33 subjects without structural changes in the brain parenchyma as confirmed by craniocerebral magnetic resonance (control group) were included in this study. The mini-mental state examination scale (MMSE) and the Montreal cognitive assessment (MoCA

Beijing) were used to evaluate the global cognitive function of the subjects. The digital span test (a subentry of the Wechsler adult intelligence scale) and the clinical memory scale were used to evaluate the attention and memory abilities of the subjects

respectively. The characteristics of cognitive impairment caused by occipital periventricular leukoaraiosis were analyzed in the patients.

Results

Compared with the control group

the patients with occipital periventricular leukoaraiosis had significantly lower average total scores of MMSE and MoCA (

0.01) with also lower scores in the subentries including orientation

short-term memory

delayed memory directed memory and language tests (

0.01

0.05); the scores of the other subentries were comparable between the 2 groups (

0.05). The patients in the mixed group had significantly lower average total scores of MMSE and MoCA (

0.01) and lower scores for orientation

memory

attention

visual spatial and execution

and language abilities as well as for abstract cognition than the control group (

0.01

0.05).

Conclusion

Isolated occipital periventricular leukoaraiosis causes cognitive impairments characterized by orientation

memory and language incompetence.

关键词

Keywords

references

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