太赫兹光谱技术用于肺癌检测的初步探索研究

刘丁瑗; 施长城; 周向东

doi:10.16016/j.1000-5404.201702014

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太赫兹光谱技术用于肺癌检测的初步探索研究

临床医学 | 更新时间：2026-01-09

- 太赫兹光谱技术用于肺癌检测的初步探索研究
- Terahertz spectroscopy for lung cancer detection: a preliminary study
- 第三军医大学学报 2017年39卷第17期页码：1739-1743
- 作者机构：
  
  1.400038 重庆，第三军医大学西南医院呼吸内科
  2.400714 重庆，中国科学院重庆绿色智能技术研究院
- 作者简介：
  
  [周向东，E-mail：xiangdongzhou@126.com ZHOU Xiangdong, E-mail: xiangdongzhou@126.com
- 基金信息：
  
  工程物理与生物医学交叉实验室孵化基金(2010年)
- DOI：10.16016/j.1000-5404.201702014
  中图分类号： O433.4;R730.49;R734.2
- 收稿：2017-02-05，
  
  修回：2017-05-01，
  
  纸质出版：2017-09-15
- 稿件说明：
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刘丁瑗, 施长城, 周向东. 太赫兹光谱技术用于肺癌检测的初步探索研究[J]. 第三军医大学学报, 2017,39(17):1739-1743.

Dingyuan LIU, Changcheng SHI, Xiangdong ZHOU. Terahertz spectroscopy for lung cancer detection: a preliminary study[J]. Journal of Third Military Medical University, 2017, 39(17): 1739-1743.
刘丁瑗, 施长城, 周向东. 太赫兹光谱技术用于肺癌检测的初步探索研究[J]. 第三军医大学学报, 2017,39(17):1739-1743. DOI： 10.16016/j.1000-5404.201702014.

Dingyuan LIU, Changcheng SHI, Xiangdong ZHOU. Terahertz spectroscopy for lung cancer detection: a preliminary study[J]. Journal of Third Military Medical University, 2017, 39(17): 1739-1743. DOI： 10.16016/j.1000-5404.201702014.

摘要

目的

利用太赫兹光谱技术，对人肺癌组织进行检测，比较肺癌组织、癌旁组织及正常肺组织之间的差异，筛选出具有特异性诊断价值的太赫兹频段，初步探索太赫兹光谱技术用于肺癌的早期检测。

方法

收集2015年6月至2015年12月经我院胸外科手术切除、病理明确诊断为Ⅰ~ⅢA期非小细胞肺癌患者30例，其肺癌组织病理类型为：腺癌17例、鳞癌10例、大细胞肺癌2例、肉瘤样癌1例。每组包括同一患者肺癌组织、癌旁组织及正常肺组织。运用频段为0.2~2.0 THz的太赫兹光谱进行检测，对比3类组织标本对太赫兹光谱的吸收率。

结果

① 肺癌组织对太赫兹光谱吸收率显著高于正常肺组织；② 太赫兹光谱频段1.4~2.0 THz可能为具有肺癌特异性诊断价值的太赫兹频段。

结论

鉴于肺癌组织对太赫兹光谱吸收率高于正常肺组织，太赫兹光谱技术可能成为一种新型非侵入诊断肺癌的检测技术，其具有特异性诊断价值的太赫兹频段可能为1.4~2.0 THz。

Abstract

Objective

To preliminarily explore the application of terahertz spectroscopy in the early detection of lung cancer by comparing the differences among lung cancer tissues

paracancerous tissues

and normal lung tissues with terahertz spectroscopy and screen the suitable terahertz frequency for specific diagnosis of lung cancer.

Methods

Thirty groups of lung tissue samples from non-small cell lung cancer patients at stage of Ⅰ to ⅢA were collected

and each group contained lung cancer tissue

paracancerous tissues

and normal lung tissue from the same patient. These lung cancer specimens included 17 cases of adenocarcinoma

10 cases of squamous cell carcinoma

2 cases of large cell lung cancer

and 1 case of sarcomatoid carcinoma. Terahertz spectroscopy from 0.2 THz to 2.0 THz was used to detect these tissue samples

and the absorption coefficient was compared.

Results

① The absorption coefficient was significantly higher in the lung cancer tissues than the normal lung tissues. ② Terahertz spectroscopy at a frequency of 0.8 to 1.4 THz may have the specific diagnostic value of lung cancer.

Conclusion

Since the absorption rate is higher in the lung cancer than the normal lung tissue

which is suggested that terahertz spectroscopy may be regarded as a novel non-invasive diagnostic approach for lung cancer. The specific diagnostic value of the terahertz frequency may be 1.4-2.0 THz for lung cancer.

关键词

Keywords

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