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兔腹主动脉分叉双支架术模型的建立
Establishment of a rabbit model of double stenting in the aortoiliac bifurcation
- 第三军医大学学报 2017年39卷第10期 页码：971-976
- 作者机构：
400037 重庆，第三军医大学新桥医院心血管内科，全军心血管病研究所
- 作者简介：
[赵晓辉, 电话：（023）68774569，E-mail:doctorzhaoxiaohui@yahoo.com Zhao Xiaohui, Tel:86-23-68774569, E-mail: doctorzhaoxiaohui@yahoo.com
- 基金信息：国家自然科学基金面上项目(81370213);国家自然科学基金面上项目(81670428)
DOI：10.16016/j.1000-5404.201701075
中图分类号： R-332;R540.46;R543.3收稿：2017-01-12，
修回：2017-03-07，
纸质出版：2017-05-30
- 稿件说明：
移动端阅览
肖寒, 谭亚军, 王玉清, 等. 兔腹主动脉分叉双支架术模型的建立[J]. 第三军医大学学报, 2017,39(10):971-976.
Han Xiao, Yajun Tan, Yuqing Wang, et al. Establishment of a rabbit model of double stenting in the aortoiliac bifurcation[J]. Journal of Third Military Medical University, 2017, 39(10): 971-976.
肖寒, 谭亚军, 王玉清, 等. 兔腹主动脉分叉双支架术模型的建立[J]. 第三军医大学学报, 2017,39(10):971-976. DOI： 10.16016/j.1000-5404.201701075.
Han Xiao, Yajun Tan, Yuqing Wang, et al. Establishment of a rabbit model of double stenting in the aortoiliac bifurcation[J]. Journal of Third Military Medical University, 2017, 39(10): 971-976. DOI： 10.16016/j.1000-5404.201701075.
摘要
目的
2
建立兔腹主动脉分叉双支架术模型。
方法
2
雄性新西兰兔5只（体质量3. 0 ~ 3.5 kg），麻醉消毒后，经颈动脉途径于腹主动脉-髂动脉血管分叉处采用边支支架微突T支架技术（T-stenting and small protrusion，TAP）实施双支架植入术，利用数字减影血管造影（digital subtraction angi-ography，DSA）、血管内超声（intravascular ultrasound，IVUS）和显微CT扫描（micro computed tomography，micro-CT）进行术后即刻评价及术后6个月复查。
结果
2
可通过兔颈动脉放置6F鞘管，于腹主动脉分叉处成功实施TAP双支架术，术后即刻DSA提示支架位置满意，血流TIMI 3级，IVUS提示支架贴壁良好，术后6个月复查DSA提示无支架内再狭窄及血栓形成，血流TIMI 3级，IVUS提示支架贴壁良好，无支架内再狭窄，micro-CT可见边支开口处支架覆盖完全，无支架内血栓，右侧髂动脉支架下缘微突入腹主动脉管腔[（0.49 ± 0.08）mm]。
结论
2
成功建立了兔腹主动脉分叉双支架术模型，为冠脉分叉病变的临床前期研究提供了依据。
Abstract
Objective
2
To establish a rabbit model of double stenting in the aortoiliac bifurcation.
Methods
2
Five normal New Zealand rabbits were anesthetized for double stent placement in the aortoiliac bifurcation
via
the left carotid artery using T-stenting and small protrusion (TAP) technique. The immediate and follow-up outcomes at 6 months after stent placement were evaluated with digital subtraction angiography (DSA)
intravascular ultrasound (IVUS) and micro-computed tomography (micro-CT).
Results
2
A 6F artery sheath was placed in the left carotid artery
and IVUS showed that the diameter of the abdominal aorta and the iliac artery was 3. 0 and 2. 5 mm
respectively. TAP technique was successfully performed for double stenting in the aortoiliac bifurcation. DSA and IVUS showed optimal stent apposition with a Thrombolysis In Myocardial Infarction(TIMI) flow grade 3. At 6 months after stent placement
DSA showed a TIMI flow grade 3 without in-stent thrombus or restenosis
and IVUS showed optimal stent apposition without restenosis. Micro-CT revealed a complete coverage of the side-branch ostium by the stent
whose lower edges slightly protruded into the abdominal aortic lumen by 0. 49 ± 0. 08 mm without in-stent thrombosis.
Conclusion
2
We successfully established a rabbit model of double stenting in the aortoiliac bifurcation for pre-clinical study of coronary bifurcation lesions.
关键词
Keywords
references
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