表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析

张丹; 陈康; 谯智慧; 谢兵; 陈伟; 熊玮

doi:10.16016/j.1000-5404.201612077

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表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析

临床医学 | 更新时间：2026-01-09

- 表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析
- Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer
- 第三军医大学学报 2017年39卷第9期页码：913-918
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201612077
  中图分类号：
- 收稿：2016-12-12，
  
  纸质出版：2017-05-15
- 稿件说明：
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张丹, 陈康, 谯智慧, 等. 表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析[J]. 第三军医大学学报, 2017,39(9):913-918.

Dan Zhang, Kang Chen, Zhihui Qiao, et al. Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer[J]. Journal of Third Military Medical University, 2017, 39(9): 913-918.
张丹, 陈康, 谯智慧, 等. 表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析[J]. 第三军医大学学报, 2017,39(9):913-918. DOI： 10.16016/j.1000-5404.201612077.

Dan Zhang, Kang Chen, Zhihui Qiao, et al. Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer[J]. Journal of Third Military Medical University, 2017, 39(9): 913-918. DOI： 10.16016/j.1000-5404.201612077.

摘要

Abstract

Objective

To analyze the correlation of apparent diffusion coefficient (ADC) with common prognostic molecular biological indicators of non-small cell lung cancer (NSCLC).

Methods

Thirty-nin

e patients with histopathologically conformed NSCLC admitted in the Department of Respiratory Diseases from April 2015 to September 2016 were recruited in this study. All the patients underwent diffusion weighted imaging (DWI)

ADCs were calculated based on DW images. Students'

test and single factor analysis of variance were applied to analyze the differences of ADCs in biological indicators

serum cancer embryo antigen (CEA)

positive rate of Ki67

thyroid transcription factor 1 (TTF-1)

and epidermal growth factor receptor (EGFR). Spearman rank correlation was used to analyze the correlations of the ADCs with above indicators.

Results

The ADCs in different indicators

such as CEA

Ki67

TTF-1 and EGFR were significantly different (

0.01). Negative correlations were found between ADCs and above biological indicators (CEA:

=-0.77

0.001; Ki67:

=-0.58

0.001; TTF-1:

=-0.47

=0.003; EGFR:

=-0.40

=0.012).

Conclusion

ADCs are negatively correlated with common prognostic indicators CEA

Ki67

TTF-1 and EGFR. Lower ADCs commonly suggest higher CEA and Ki67

which might predict positive TTF-1 and EGFR mutations.

关键词

Keywords

references

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