肝X受体β在皮肤鳞状细胞癌中的表达及其临床意义

何仁颖; 张斌; 吴峰; 李冉; 李漪倩; 周源; 何威

doi:10.16016/j.1000-5404.201612050

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肝X受体β在皮肤鳞状细胞癌中的表达及其临床意义

临床医学 | 更新时间：2026-01-09

- 肝X受体β在皮肤鳞状细胞癌中的表达及其临床意义
- Expression and clinical significance of liver X receptor β in cutaneous squamous cell carcinoma
- 第三军医大学学报 2017年39卷第9期页码：919-923
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金青年科学基金(81502369)
- DOI：10.16016/j.1000-5404.201612050
  中图分类号：
- 收稿：2016-12-07，
  
  纸质出版：2017-05-15
- 稿件说明：
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何仁颖, 张斌, 吴峰, 等. 肝X受体β在皮肤鳞状细胞癌中的表达及其临床意义[J]. 第三军医大学学报, 2017,39(9):919-923.

Renying He, Bin Zhang, Feng Wu, et al. Expression and clinical significance of liver X receptor β in cutaneous squamous cell carcinoma[J]. Journal of Third Military Medical University, 2017, 39(9): 919-923.
何仁颖, 张斌, 吴峰, 等. 肝X受体β在皮肤鳞状细胞癌中的表达及其临床意义[J]. 第三军医大学学报, 2017,39(9):919-923. DOI： 10.16016/j.1000-5404.201612050.

Renying He, Bin Zhang, Feng Wu, et al. Expression and clinical significance of liver X receptor β in cutaneous squamous cell carcinoma[J]. Journal of Third Military Medical University, 2017, 39(9): 919-923. DOI： 10.16016/j.1000-5404.201612050.

摘要

Abstract

Objective

To investigate the expression and significance of liver X receptor β (LXRβ) in cutaneous squamous cell carcinoma (cSCC).

Methods

PCR array and Western blotting were performed to detect the expression level of LXRβ transcriptionally and translationally in human normal keratinocytes (KC cells) and skin squamous cell carcinoma cell line A431. Immunohistochemical staining (Envision method) was used to reveal the expression pattern of LXRβ in the tissues from 52 cases of actinic keratosis (AK)

40 cases of Bowen's disease (BD) and 60 cases of cSCC. The correlation of the expression of LXRβ was analyzed with clinical parameters.

Results

Compared with the KC cells

the mRNA and protein levels of LXRα and LXRβ were higher in the A431 cells

especially those of LXRβ. Immunohistochemical staining demonstrated that LXRβ expression level was increased gradually form AK

BD to cSCC tissues. Its expression was correlated with differentiation

tumor size and invasion (

0.05)

but not with age

gender and tumor location (

0.05).

Conclusion

LXRβ is highly expressed in cSCC cells and tissues

and correlated with cancer proliferation and differentiation.

关键词

Keywords

references

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