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miRNA基因单核苷酸多态性与非小细胞肺癌易感性的关联研究
Genetic association of single nucleotide polymorphisms in miRNAs with NSCLC susceptibility
- 第三军医大学学报 2017年39卷第9期 页码：904-912
- 作者机构：
- 作者简介：
- 基金信息：国家自然科学基金面上项目(81171903);国家自然科学基金面上项目(81472190);国家自然科学基金面上项目(81672316);重庆市自然科学基金重点项目(CSTC2015jcyjBX0110)
DOI：10.16016/j.1000-5404.201611091
中图分类号：收稿：2016-11-10，
纸质出版：2017-05-15
- 稿件说明：
移动端阅览
汪君君, 谢薇佳, 袁帅, 等. miRNA基因单核苷酸多态性与非小细胞肺癌易感性的关联研究[J]. 第三军医大学学报, 2017,39(9):904-912.
Junjun Wang, Weijia Xie, Shuai Yuan, et al. Genetic association of single nucleotide polymorphisms in miRNAs with NSCLC susceptibility[J]. Journal of Third Military Medical University, 2017, 39(9): 904-912.
汪君君, 谢薇佳, 袁帅, 等. miRNA基因单核苷酸多态性与非小细胞肺癌易感性的关联研究[J]. 第三军医大学学报, 2017,39(9):904-912. DOI： 10.16016/j.1000-5404.201611091.
Junjun Wang, Weijia Xie, Shuai Yuan, et al. Genetic association of single nucleotide polymorphisms in miRNAs with NSCLC susceptibility[J]. Journal of Third Military Medical University, 2017, 39(9): 904-912. DOI： 10.16016/j.1000-5404.201611091.
摘要
Abstract
Objective
2
To explore the association between single nucleotide polymorphisms (SNPs) in miRNA and the risk of non-small cell lung cancer (NSCLC).
Methods
2
A total of 13 candidate SNPs of different miRNA genes were identified by bioinformatics analysis. A case-control study was performed in 626 patients with NSCLC and 736 controls. Genomic DNA was extracted from peripheral blood cells
and the S
NPs were genotyped by SNPscan
TM
system. A multivariate logistic regression analysis was applied to evaluate the association between NSCLC risk and each selected SNP in miRNA level.
Results
2
Of the 13 SNPs
3 (rs62085660
rs11597888
and rs16867808) showed significant association with NSCLC risk
and this association was limited to specific subgroup of subjects. The SNP rs62085660 (C/G) showed a significant association with the risk of lung squamous carcinoma (additive model:
OR
adjusted
=0.79
95%
CI
=0.62~1.00
P
=0.049; dominant model:
OR
adjusted
=0.72
95%
CI
=0.53~0.98
P
=0.035). In smokers
rs11597888 (G/A) and rs16867808 (T/C) were significantly associated with NSCLC risk (rs11597888: dominant model
OR
adjusted
=1.42
95%
CI
=1.03~1.96
P
=0.033; rs16867808: additive model
OR
adjusted
=0.58
95%
CI
=0.40~0.84
P
=0.004; dominant model
OR
adjusted
=0.53
95%
CI
=0.35~0.81
P
=0.004).
Conclusion
2
rs62085660 SNP may contribute to genetic susceptibility to lung squamous carcinomas
and rs16867808 SNP to genetic susceptibility to NSCLC in smoking population.
关键词
Keywords
references
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