早期APP/PS1转基因阿尔茨海默病小鼠海马结构内有髓神经纤维改变的体视学研究

赵振华; 晁凤蕾; 张蕾; 张毅; 周春妮; 蒋林; 肖倩; 罗艳敏; 黄维; 李常琼; 唐炜; 李桃; 唐勇

doi:10.16016/j.1000-5404.201610106

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早期APP/PS1转基因阿尔茨海默病小鼠海马结构内有髓神经纤维改变的体视学研究

基础医学 | 更新时间：2026-01-09

- 早期APP/PS1转基因阿尔茨海默病小鼠海马结构内有髓神经纤维改变的体视学研究
- Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study
- 第三军医大学学报 2017年39卷第8期页码：760-766
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上项目(81470057);国家自然科学基金面上项目(81671259);国家自然科学基金面上项目(81501101);重庆市首批“百名学术学科领军人才”培养计划(2012);2016年重庆医科大学优秀博士论文资助项目;2016年重庆市研究生科研创新项目
- DOI：10.16016/j.1000-5404.201610106
  中图分类号：
- 纸质出版：2017-04
- 稿件说明：
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赵振华, 晁凤蕾, 张蕾, 等. 早期APP/PS1转基因阿尔茨海默病小鼠海马结构内有髓神经纤维改变的体视学研究[J]. 第三军医大学学报, 2017,39(8):760-766.

Zhenhua Zhao, Fenglei Chao, Lei Zhang, et al. Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study[J]. Journal of Third Military Medical University, 2017, 39(8): 760-766.
赵振华, 晁凤蕾, 张蕾, 等. 早期APP/PS1转基因阿尔茨海默病小鼠海马结构内有髓神经纤维改变的体视学研究[J]. 第三军医大学学报, 2017,39(8):760-766. DOI： 10.16016/j.1000-5404.201610106.

Zhenhua Zhao, Fenglei Chao, Lei Zhang, et al. Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study[J]. Journal of Third Military Medical University, 2017, 39(8): 760-766. DOI： 10.16016/j.1000-5404.201610106.

摘要

Abstract

Objective

To investigate the changes of myelinated fibers and myelin sheaths in the hippocampus of APP/PS1 transgenetic mice with early onset of symptoms of Alzheimer's Disease (AD).

Methods

The spatial learning and memory abilities of 10-month-old APP/PS1 transgenic mice and wild-type mice were evaluated with Morris water maze test. The volume of the hippocampus

CA1 and the dentate gyrus (DG)

and the length of the myelinated nerve fibers and the total volume of the myelinated nerve fibers and myelin sheathes in the CA1 region and the DG were determined using an unbiased stereological method coupled with electron microscope technique.

Results

Compared with the wild-type mice

the transgenic mice showed a significantly increas

ed mean escape latency (

0.05) and a decreased percentage of time staying in the target quadrant (

0.01)

but with comparable frequencies of crossing the platform location (

0.05). The volumes of the hippocampus

CA1 region and the DG were significantly decreased in the transgenic mice compared with those in the wild-type mice (

0.01

0.05). The total length of the myelinated fibers in the hippocampal CA1 region and DG did not differ significantly between the transgenic and wild-type mice (

0.05)

but the total volumes of the myelinated fibers and myelin sheathes in the hippocampal CA1 region and DG were significantly smaller in the transgenic mice (

0.05

0.01).

Conclusion

Demyelization occurs in the hippocampal CA1 region and DG of 10-month-old APP/PS1 transgenic mice that show early AD symptoms

and these changes might contribute as one of the structural basis to memory and learning deficits in the mice.

关键词

Keywords

references

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