脉冲与连续高强度聚焦超声对离体牛肝表面消融的效果比较

文静; 邹建中; 王琦; 马大钊; 丁晓亚

doi:10.16016/j.1000-5404.201610064

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脉冲与连续高强度聚焦超声对离体牛肝表面消融的效果比较

基础医学 | 更新时间：2026-01-09

- 脉冲与连续高强度聚焦超声对离体牛肝表面消融的效果比较
- Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver
- 第三军医大学学报 2017年39卷第8期页码：749-754
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家重点基础研究发展计划(973计划);国家重点基础研究发展计划(2011CB707900);国家自然科学基金委重大科学仪器设备研制专项资助项目(81127901);国家自然科学基金面上项目(11574039);国家自然科学基金面上项目(11274404)
- DOI：10.16016/j.1000-5404.201610064
  中图分类号：
- 收稿：2016-10-12，
  
  纸质出版：2017-04-30
- 稿件说明：
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文静, 邹建中, 王琦, 等. 脉冲与连续高强度聚焦超声对离体牛肝表面消融的效果比较[J]. 第三军医大学学报, 2017,39(8):749-754.

Jing Wen, Jianzhong Zou, Qi Wang, et al. Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver[J]. Journal of Third Military Medical University, 2017, 39(8): 749-754.
文静, 邹建中, 王琦, 等. 脉冲与连续高强度聚焦超声对离体牛肝表面消融的效果比较[J]. 第三军医大学学报, 2017,39(8):749-754. DOI： 10.16016/j.1000-5404.201610064.

Jing Wen, Jianzhong Zou, Qi Wang, et al. Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver[J]. Journal of Third Military Medical University, 2017, 39(8): 749-754. DOI： 10.16016/j.1000-5404.201610064.

摘要

Abstract

Objective

To compare the effect of surface ablation with continuous high-intensity focused ultrasound (CHIFU) and pulsed high-intensity focused ultrasound (PHIFU) and investigate the optimization of surface ablation mode with HIFU.

Methods

Forty samples of fresh bovine liver tissues were divided into group A (

=30) and group B (

=10) for surface ablation with PHIFU and CHIFU

respectively. According to the duty cycles

the samples in group A were divided into 3 equal subgroups with duty cycles of 10% (group A1)

30% (group A2)

and 50% (group A3). With ultrasonographic guidance

the target areas in the liver tissues were irradiated with PHIFU and CHIFU for surface ablation

and the temperature changes in the geometric center of the target area were recorded. After ablation

tissue damages in the peripheral area and the areas within and outside the target area were observed

the energy efficiency factor (EEF) was calculated

and the temperature-time curve was analyzed.

Results

Compared with that in group B

the EEF in the 3 subgroups in group A all reduced significantly (

0.05)

and the reduction became more prominent as the duty cycles increased. Thermal damage outside the target area was observed only in group B. In each group

confined lesions were formed following the ablation

and the irradiated areas showed liquid necrosis in subgroup A1 and coagulation necrosis in the other groups. Within the target area of ablation

the tissue damage was intensified as the duty cycle increased

and the peak temperature in the center of the target area exceeded 60 ℃ in all the groups only with the exception of group A1.

Conclusion

Compared with CHIFU surface ablation

PHIFU surface ablation has a greater ablation efficiency and reduces tissue damage outside the target area. In PHIFU peripheral ablation

the temperature and tissue damage of the non-irradiated internal tissue within the target area can be controlled by adjusting the duty cycles.

关键词

Keywords

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