双酚A与不明原因复发性流产发生关系的病例对照研究

王明远; 陈诚; 潘峰; 刘小艳; 常青

doi:10.16016/j.1000-5404.201610025

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双酚A与不明原因复发性流产发生关系的病例对照研究

更新时间：2026-01-09

- 双酚A与不明原因复发性流产发生关系的病例对照研究
- Association of bisphenol A with unexplained recurrent spontaneous abortion: a case-control research
- 第三军医大学学报 2017年39卷第6期页码：579-583
- 作者机构：
  
  1.400038 重庆，第三军医大学：西南医院妇产科
  2.400038 重庆，第三军医大学：生物医学分析测试中心
- 作者简介：
  
  [常青,E-mail :cqli99@126.com Chang Qing, E-mail: cqli99@126.com
- 基金信息：
  
  国家科技支撑计划(2013BAI12B00)
- DOI：10.16016/j.1000-5404.201610025
  中图分类号： R347.913; R446.112; R714.21
- 收稿：2016-06-14，
  
  修回：2016-07-25，
  
  纸质出版：2017-06
- 稿件说明：
移动端阅览
王明远, 陈诚, 潘峰, 等. 双酚A与不明原因复发性流产发生关系的病例对照研究[J]. 第三军医大学学报, 2017,39(6):579-583.

Mingyuan Wang, Cheng Chen, Feng Pan, et al. Association of bisphenol A with unexplained recurrent spontaneous abortion: a case-control research[J]. Journal of Third Military Medical University, 2017, 39(6): 579-583.
王明远, 陈诚, 潘峰, 等. 双酚A与不明原因复发性流产发生关系的病例对照研究[J]. 第三军医大学学报, 2017,39(6):579-583. DOI： 10.16016/j.1000-5404.201610025.

Mingyuan Wang, Cheng Chen, Feng Pan, et al. Association of bisphenol A with unexplained recurrent spontaneous abortion: a case-control research[J]. Journal of Third Military Medical University, 2017, 39(6): 579-583. DOI： 10.16016/j.1000-5404.201610025.

摘要

目的

探讨环境主要污染物——类雌激素双酚A对女性复发性流产 (胚胎停育) 的影响。

方法

收集2014年10月至2016年4月第三军医大学西南医院妇产科门诊不明原因复发性流产或胚胎停育患者80例，选择80例正常妊娠妇女为对照组，使用固相萃取-同位素内标-高效液相色谱质谱联用法检测血清双酚A浓度，按年龄、体质量指数 (BMI)、孕周、初潮年龄分组并进行比较，采用单因素和多因素非条件logistic回归模型分析双酚A与复发性流产发生的关联。

结果

病例组血清双酚A浓度高于对照组[39.51(19.72

57.13)

3.56(2.46

6.88) ng/mL，

0.01

]

；多因素logistic回归分析结果显示：双酚A是复发性流产的危险因素 (

=2.469)。两组间比较，双酚A浓度在年龄≤35岁、BMI、孕周、初潮年龄差异均有统计学意义 (

0.001)。

结论

双酚A可能与女性复发性流产 (胚胎停育) 有关。

Abstract

Objective

To investigate the effect of serum environment pollutant

bisphenol A

in the women with unexplained recurrent spontaneous abortion (embryo damage).

Methods

A case-control study was conducted in the outpatients of our gynecological department from October 2014 to April 2016. Eighty patients with unexplained recurrent spontaneous abortion (embryo damage) were recruited

and 8 normal pregnant women were selected as controls. The isotope dilution-solid phase extraction (SPE) and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) were used to detect free bisphenol A in the serum. The levels of serum bisphenol A were compared according to the age

body mass index (BMI)

gestation

and menarche age. Multiple factor non-conditional logistic regression analysis was adopted to analyze the relationship between bisphenol A and recurrent spontaneous abortion.

Results

The concentrations of unconjugated bisphenol A in the patients and controls were 39.51(19.72

57.13) and 3.56(2.46

6.88) ng/mL respectively (

0.01). Multiple factor non-conditional logistic regression analysis showed that serum bisphenol A was one of the risk factors causing recurrent spontaneous abortion (

=2.469). Meantime

the bisphenol A concentration were significant different in age (≤35)

BMI

gestation and menarche age.

Conclusion

High level of bisphenol A might be associated with unexplained recurrent spontaneous abortion (embryo damage).

关键词

Keywords

references

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