Torre L A Bray F Siegel R L Global cancer statistics, 2012 CA Cancer J Clin 2015 65 2 87 108 10.3322/caac.21262 Torre L A, Bray F, Siegel R L, et al . Global cancer statistics, 2012[J ] . CA Cancer J Clin, 2015, 65(2): 87-108. DOI: 10.3322/caac.21262

Chen W Zheng R Baade P D Cancer statistics in China, 2015 CA Cancer J Clin 2016 66 2 115 132 10.3322/caac.21338 Chen W, Zheng R, Baade P D, et al . Cancer statistics in China, 2015[J ] . CA Cancer J Clin, 2016, 66(2): 115-132. DOI: 10.3322/caac.21338

Degterev A Huang Z Boyce M Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Nat Chem Biol 2005 1 2 112 119 10.1038/nchembio711 Degterev A, Huang Z, Boyce M, et al . Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury[J ] . Nat Chem Biol, 2005, 1(2): 112-119. DOI:10.1038/nchembio711

Zhou R Lu Z Liu K Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo Curr Cancer Drug Targets 2015 14 9 860 871 10.2174/1568009614666141128104642 Zhou R, Lu Z, Liu K, et al . Platycodin D induces tumor growth arrest by activating FOXO3a expression in pro state cancer in vitro and in vivo [J ] . Curr Cancer Drug Targets, 2015, 14(9): 860-871.

Cheng T C Lu J F Wang J S Antiproliferation effect and apoptosis mechanism of prostate cancer cell PC-3 by flavonoids and saponins prepared from Gynostemma pentaphyllum J Agric Food Chem 2011 59 20 11319 11329 10.1021/jf2018758 Cheng T C, Lu J F, Wang J S, et al . Antiproliferation effect and apoptosis mechanism of prostate cancer cell PC-3 by flavonoids and saponins prepared from Gynostemma pentaphyllum[J ] . J Agric Food Chem, 2011, 59(20): 11319-11329. DOI: 10.1021/jf2018758

Bonapace L Bornhauser B C Schmitz M Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance J Clin Invest 2010 120 4 1310 1323 10.1172/JCI39987 Bonapace L, Bornhauser B C, Schmitz M, et al . Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance[J ] . J Clin Invest, 2010, 120(4):1310-1323.DOI: 10.1172/JCI39987

Sulkshane P Teni T BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells Oncotarget 2016 10.18632/oncotarget.11085 Sulkshane P, Teni T. BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells[J ] . Oncotarget, 2016.. DOI: 10.18632/oncotarget.11085

Li X Guo J Ding A P Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer Technol Cancer Res Treat 2016 10.1177/1533034616655909 Li X, Guo J, Ding A P, et al . Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer[J ] . Technol Can cer Res Treat, 2016.. DOI:10.1177/1533034616655909

Locatelli S L Giacomini A Guidetti A Perifosine and sorafenib combination induces mitochondrial cell death and antitumor effects in NOD/SCID mice with Hodgkin lymphoma cell line xenografts Leukemia 2013 27 8 1677 1687 10.1038/leu.2013.28 Locatelli S L, Giacomini A, Guidetti A, et al . Perifosine and sorafenib combination induces mitochondrial cell death and antitumor effects in NOD/SCID mice with Hodgkin lymphoma cell line xenografts[J ] . Leukemia, 2013, 27(8): 1677-1687. DOI: 10.1038/leu.2013.28

Rizzi F Naponelli V Silva A Polyphenon E (R), a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis Carcinogenesis 2014 35 4 828 839 10.1093/carcin/bgt481 Rizzi F, Naponelli V, Silva A, et al . Polyphenon E (R), a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis[J ] . Carcinogenesis, 2014, 35(4): 828-839. DOI: 10.1093/carcin/bgt481

Rosolen D Kretzer I F Winter E N-phenylmaleimides affect adipogenesis and present antitumor activity through reduction of FASN expression Chem Biol Interact 2016 258 10 20 10.1016/j.cbi.2016.08.005 Rosolen D, Kretzer I F, Winter E, et al . N-phenylmaleimides affect adipogenesis and present antitumor activity through reduction of FASN expression[J ] . Chem Biol Interact, 2016, 258: 10-20. DOI: 10.1016/j.cbi.2016.08.005

Vanden Berghe T Vanlangenakker N Parthoens E Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features Cell Death Differ 2010 17 6 922 930 10.1038/cdd.2009.184 Vanden Berghe T, Vanlangenakker N, Parthoens E, et al . Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features[J ] . Cell Death Differ, 2010, 17(6): 922-930. DOI: 10.1038/cdd.2009.184

Sun L Wang H Wang Z Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase Cell 2012 148 1/2 213 227 10.1016/j.cell.2011.11.031 Sun L, Wang H, Wang Z, et al . Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase[J ] . Cell, 2012, 148(1/2): 213-227. DOI: 10.1016/j.cell.2011.11.031

Dondelinger Y Declercq W Montessuit S MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates Cell Rep 2014 7 4 971 981 10.1016/j.celrep.2014.04.026 Dondelinger Y, Declercq W, Montessuit S, et al . MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosph ates[J ] . Cell Rep, 2014, 7(4): 971-981. DOI: 10.1016/j.celrep.2014.04.026

Chen X Li W Ren J Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death Cell Res 2014 24 1 105 121 10.1038/cr.2013.171 Chen X, Li W, Ren J, et al . Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death[J ] . Cell Res, 2014, 24(1): 105-121. DOI: 10.1038/cr.2013.171

He L Peng K Liu Y Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients Onco Targets Ther 2013 6 1539 1543 10.2147/OTT.S52805 He L, Peng K, Liu Y, et al . Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients[J ] . Onco Targets Ther, 2013, 6: 1539-1543. DOI: 10.2147/OTT.S52805

Colbert L E Fisher S B Hardy C W Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma Cancer 2013 119 17 3148 3155 10.1002/cncr.28144 Colbert L E, Fisher S B, Hardy C W, et al . Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma[J ] . Cancer, 2013, 119(17): 3148-3155. DOI: 10.1002/cncr.28144

Mantel F Frey B Haslinger S Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells Strahlenther Onkol 2010 186 11 587 599 10.1007/s00066-010-2154-x Mantel F, Frey B, Haslinger S, et al . Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells[J ] . Strahlenther Onkol, 2010, 186(11): 587-599. DOI: 10.1007/s00066-010-2154-x

Yamashima T Oikawa S The role of lysosomal rupture in neuronal death Prog Neurobiol 2009 89 4 343 358 10.1016/j.pneurobio.2009.09.003 Yamashima T, Oikawa S. The role of lysosomal rupture in neuronal death[J]. Prog Neurobiol, 2009, 89(4):343-358.DOI:10.1016/j.pneurobio.2009.09.003

Shindo R Kakehashi H Okumura K Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation Biochem Biophys Res Commun 2013 436 2 212 216 10.1016/j.bbrc.2013.05.075 Shindo R, Kakehashi H, Okumura K, et al . Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation[J ] . Biochem Biophys Res Commun, 2013, 436(2): 212-216. DOI: 10.1016/j.bbrc.2013.05.075