血栓弹力图检测动脉瘤性蛛网膜下腔出血后血小板功能变化及与再出血的关系

何秋光; 郭宗铎; 张晓冬; 蒋永祥; 马颖; 程远; 孙晓川

doi:10.16016/j.1000-5404.201609009

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血栓弹力图检测动脉瘤性蛛网膜下腔出血后血小板功能变化及与再出血的关系

临床医学 | 更新时间：2026-01-09

- 血栓弹力图检测动脉瘤性蛛网膜下腔出血后血小板功能变化及与再出血的关系
- Thromboelastography for platelet function changes in aneurysmal subarachnoid hemorrhage patients and relationship of the results with rebleeding
- 第三军医大学学报 2017年39卷第3期页码：276-280
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201609009
  中图分类号：
- 收稿：2016-09-01，
  
  纸质出版：2017-01-15
- 稿件说明：
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何秋光, 郭宗铎, 张晓冬, 等. 血栓弹力图检测动脉瘤性蛛网膜下腔出血后血小板功能变化及与再出血的关系[J]. 第三军医大学学报, 2017,39(3):276-280.

Qiuguang He, Zongduo Guo, Xiaodong Zhang, et al. Thromboelastography for platelet function changes in aneurysmal subarachnoid hemorrhage patients and relationship of the results with rebleeding[J]. Journal of Third Military Medical University, 2017, 39(3): 276-280.
何秋光, 郭宗铎, 张晓冬, 等. 血栓弹力图检测动脉瘤性蛛网膜下腔出血后血小板功能变化及与再出血的关系[J]. 第三军医大学学报, 2017,39(3):276-280. DOI： 10.16016/j.1000-5404.201609009.

Qiuguang He, Zongduo Guo, Xiaodong Zhang, et al. Thromboelastography for platelet function changes in aneurysmal subarachnoid hemorrhage patients and relationship of the results with rebleeding[J]. Journal of Third Military Medical University, 2017, 39(3): 276-280. DOI： 10.16016/j.1000-5404.201609009.

摘要

Abstract

Objective

To detect the changes of platelet function in the patients with aneurysmal subarachnoid hemorrhage (aSAH) by thromboelastography (TEG)

and investigate the relationship of the results with rebleeding.

Methods

A retrospective study was carried out on 259 aSAH patients and 39 patients with unruptured intracranial aneurysms who admitted in the First Affiliated Hospital from August 2014 to August 2015. They all underwent TEG on admission. The relationship of TEG parameters with the results of Hunt-Hess grading system and Fisher grading scale were analyzed. The aSAH patients were further divided into rebleeding and non-rebleeding subgroups. Clinical data

platelet level and TEG parameters were compared between the 2 subgroups.

Results

The inhibitory rate of adenosine diphosphate (ADP) was significantly higher in the aSAH patients than the UIA patients (

=1 505

0.01). And the inhibitory rate was positively correlated with Hunt-Hess grade (

=0.387

0.01) as well as Fisher grade (

=0.382

0.01). The aSAH patients with rebleeding had higher inhibitory rates of ADP and arachidonic acid (AA) than those without rebleeding (

0.05

0.01).

Conclusion

Platelet dysfunction is present after aSAH

and rebleeding is correlated with obvious decline of platelet function. Using TEG for platelet function can be considered as an early warning indicator to assess the risk of rebleeding after aSAH.

关键词

Keywords

references

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