浏览全部资源
扫码关注微信
SOCS1基因单核苷酸多态性与凉山彝族人群肺结核发生风险的关联性研究
Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority
- 第三军医大学学报 2017年39卷第3期 页码：291-295
- 作者机构：
- 作者简介：
- 基金信息：国家自然科学基金面上项目(81371760);国家传染病重大专项(2013ZX10003006-003-002)
DOI：10.16016/j.1000-5404.201608118
中图分类号：收稿：2016-08-22，
纸质出版：2017-01-15
- 稿件说明：
移动端阅览
汪超, 蒋文斌, 薛艳霞, 等. SOCS1基因单核苷酸多态性与凉山彝族人群肺结核发生风险的关联性研究[J]. 第三军医大学学报, 2017,39(3):291-295.
Chao Wang, Wenbin Jiang, Yanxia Xue, et al. Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority[J]. Journal of Third Military Medical University, 2017, 39(3): 291-295.
汪超, 蒋文斌, 薛艳霞, 等. SOCS1基因单核苷酸多态性与凉山彝族人群肺结核发生风险的关联性研究[J]. 第三军医大学学报, 2017,39(3):291-295. DOI： 10.16016/j.1000-5404.201608118.
Chao Wang, Wenbin Jiang, Yanxia Xue, et al. Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority[J]. Journal of Third Military Medical University, 2017, 39(3): 291-295. DOI： 10.16016/j.1000-5404.201608118.
摘要
Abstract
Objective
2
To investigate the genetic association of 2 tag single nucleotide polymorphisms (tagSNP) of suppressor of cytokine signaling 1 (SOCS1) gene
rs243327 and rs33932899 with the risk of pulmonary tuberculosis in the people of Yi ethnic minority living in Liangshan
Sichuan Province.
Methods
2
A total of 188 patients of Yi nationality with pulmonary tuberculosis and 229 Yi healthy people were enrolled in this study. Their blood samples were collected during March 2015 and June 2016 in Liangshan Yi Autonomous Prefecture. Two tagSNP polymorphisms were analyzed by gene sequencing
and the genotype and allele frequency between pulmonary tuberculosis group and healthy control group were determined by Chi square test.
Results
2
Both rs243327 and rs3393289 showed no deviation from Hardy-Weinberg equilibrium (HWE) in either the case or the control. The results showed that there was a significant correlation between rs243327 polymorphism and pulmonary tuberculosis
and the frequency of CC genotype was higher in pulmonary tuberculosis patients than healthy control (CC
vs
CT:
OR
=1.611
95%
CI
: 1.058~2.453
P
=0.026; CC
vs
CT+TT:
OR
=1.651
95%
CI
: 1.107~2.461
P
=0.014)
indicating that CC carriers of rs243327 may increase the risk of pulmonary tuberculosis in Yi people
and had genetic susceptibility of tuberculosis. Meanwhile
the frequency of C allele was also higher in the patients than the healthy control (C
vs
T:
OR
=1.516
95%
CI
: 1.089~2.109
P
=0.013)
and C allele might be susceptible allele for pulmonary tuberculosis. While there was no significant correlation between rs33932899 polymorphism and pulmonary tuberculosis (GG
vs
CG:
OR
=1.148
95%
CI
: 0.762~1.731
P
=0.436; GG
vs
CC:
OR
=2.184
95%
CI
: 0.874~5.454
P
=0.088; GG
vs
CG+CC:
OR
=1.229
95%
CI
: 0.875~1.928
P
=0.193;G
vs
C:
OR
=1.290
95%
CI
: 0.932~1.785
P
=0.124). This indicated that rs33932899 was not associated with the susceptibility of pulmonary tuberculosis.
Conclusion
2
rs243327 polymorphism may be associated with the occurrence and development of pulmonary tuberculosis in the Liangshan Yi population.
关键词
Keywords
references
Nair N Cooreman E Working towards TB elimination the WHO Regional Strategic Plan (2006-2015) J Commum Dis 2006 38 3 185 190 http://www.ncbi.nlm.nih.gov/pubmed/17373351 Nair N, Cooreman E. Working towards TB elimination the WHO Regional Strategic Plan (2006-2015)[J].J Commum Dis, 2006, 38(3): 185-190.
Comstock G W Tuberculosis in twins: a re-analysis of the prophit survey Am Rew Respir Dis 1978 117 4 621 624 10.1164/arrd.1978.117.4.621 Comstock G W. Tuberculosis in twins: a re-analysis of the prophit survey[J].Am Rew Respir Dis, 1978, 117(4): 621-624. DOI:10.1164/arrd.1978.117.4.621
Di Pietrantonio T Schurr E Host-pathogen specificity in tuberculosis Adv Exp Med Biol 2013 783 33 44 10.1007/978-1-4614-6111-1_2 Di Pietrantonio T, Schurr E. Host-pathogen specificity in tuberculosis[J]. Adv Exp Med Biol, 2013, 783: 33-44. DOI:10.1007/978-1-4614-6111-1_2
周 莹 高 琪乐 黄 华艺 宿主基因多态性与结核易感性研究进展 中华医院感染学杂志 2016 26 2 477 480 10.11816/cn.ni.2016-150859 周莹, 高琪乐, 黄华艺, 等.宿主基因多态性与结核易感性研究进展[J].中华医院感染学杂志, 2016, 26(2): 477-480. DOI:10.11816/cn.ni.2016-150859
周 江 张 万江 甘露聚糖结合凝集素基因A/B位点与新疆维吾尔族结核病的相关性研究 中国防痨杂志 2012 34 7 445 451 http://www.cnki.com.cn/Article/CJFDTOTAL-ZFLZ201207011.htm 周江, 张万江.甘露聚糖结合凝集素基因A/B位点与新疆维吾尔族结核病的相关性研究[J].中国防痨杂志, 2012, 34(7): 445-451.
王 喜 任 玲君 李 秀玲 新疆维吾尔族人群HLA-DR、DQ基因多态性与结核病易感性的研究 中国防痨杂志 2011 33 4 197 203 http://www.cnki.com.cn/Article/CJFDTOTAL-ZFLZ201104002.htm 王喜, 任玲君, 李秀玲, 等.新疆维吾尔族人群HLA-DR、DQ基因多态性与结核病易感性的研究[J].中国防痨杂志, 2011, 33(4): 197-203.
吴 芳 . 结核易感基因多态性与新疆哈萨克族结核病易感性的相关性研究 [D ] . 武汉 : 华中科技大学 , 2014 . 吴芳.结核易感基因多态性与新疆哈萨克族结核病易感性的相关性研究[D].武汉:华中科技大学, 2014.
陈 雪融 冯 玉麟 马 玙 维生素D受体基因多态性与中国藏族结核病的关联研究 四川大学学报(医学版) 2006 37 6 847 851 http://www.cnki.com.cn/Article/CJFDTOTAL-HXYK200606006.htm 陈雪融, 冯玉麟, 马玙, 等.维生素D受体基因多态性与中国藏族结核病的关联研究[J].四川大学学报(医学版), 2006, 37(6): 847-851.
李 素芝 蒋 亚建 谢 本维 中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究 第三军医大学学报 2011 33 12 1254 1257 10.16016/j.1000-5404.2011.12.007 李素芝, 蒋亚建, 谢本维, 等.中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究[J].第三军医大学学报, 2011, 33(12):1254-1257.DOI: 10.16016/j.1000-5404.2011.12.007
Masood K I Rottenberg M E Carow B SOCS1 gene expression is increased in severe pulmonary tuberculosis Scand J Immunol 2012 76 4 398 404 10.1111/j.1365-3083.2012.02731.x Masood K I, Rottenberg M E, Carow B. et al. SOCS1 gene expression is increased in severe pulmonary tuberculosis[J].Scand J Immunol, 2012, 76(4): 398-404. DOI:10.1111/j.1365-3083.2012.02731.x
Nicol A F Nuovo G J CoelhoJ M SOCS in situ expression in tuberculous lymphadenitis in an endemic area Exp Mol Pathol 2008 84 3 240 244 10.1016/j.yexmp.2008.04.001 Nicol A F, Nuovo G J, CoelhoJ M, et al. SOCS in situ expression in tuberculous lymphadenitis in an endemic area[J]. Exp Mol Pathol, 2008, 84(3): 240-244. DOI:10.1016/j.yexmp.2008.04.001
Masood K I Hussain R Rao N Differential Early Secreted Antigen Target (ESAT) 6 kDa-induced IFN-gamma and SOCS1 expression distinguishes latent and active tuberculosis J Infect Dev Ctries 2014 8 1 59 66 10.3855/jidc.3412 Masood K I, Hussain R, Rao N, et al.Differential Early Secreted Antigen Target (ESAT) 6 kDa-induced IFN-gamma and SOCS1 expression distinguishes latent and active tuberculosis[J].J Infect Dev Ctries, 2014, 8(1): 59-66. DOI: 10.3855/jidc.3412
Yang S Li F Jia S Early secreted antigen ESAT-6 of Mycobacterium Tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1 interaction Cell Physiol Biochem 2015 35 4 1276 1288 10.1159/000373950 Yang S, Li F, Jia S, et al. Early secreted antigen ESAT-6 of Mycobacterium Tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1 interaction[J ] . Cell Physiol Biochem, 2015, 35(4): 1276-1288. DOI:10.1159/000373950
Vargas-Alarcon G Posadas-Sanchez R Posadas-Romero C Association of the suppressor of cytokine signaling 1 (SOCS1) gene polymorphisms with acute coronary syndrome in Mexican patients Mol Immunol 2014 62 1 137 141 10.1016/j.molimm.2014.06.019 Vargas-Alarcon G, Posadas-Sanchez R, Posadas-Romero C, et al.Association of the suppressor of cytokine signaling 1 (SOCS1) gene polymorphisms with acute coronary syndrome in Mexican patients[J]. Mol Immunol, 2014, 62(1):137-141. DOI:10.1016/j.molimm.2014.06.019
Zhang P Li F Li N Genetic variations of SOCS1 are associated with chronic hepatitis B virus infection Human Immunology 2014 75 8 709 714 10.1016/j.humimm.2014.04.010 Zhang P, Li F, Li N, et al. Genetic variations of SOCS1 are associated with chronic hepatitis B virus infection[J]. Human Immunology, 2014, 75(8):709-714. DOI:10.1016/j.humimm.2014.04.010
0
浏览量
0
下载量
0
CSCD
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
