
浏览全部资源
扫码关注微信
1.重庆医科大学附属第一医院生殖医学中心,重庆 400016
2.巴南区第二人民医院妇产科,重庆 400054
张 越,Email:2529941241@qq.com,研究方向:生殖内分泌疾病(卵巢早衰、卵巢储备功能减退)。
王炼炼,Email:llian_w@163.com。
收稿:2025-08-04,
修回:2025-10-05,
录用:2025-10-23,
纸质出版:2026-03-28
移动端阅览
张越,马婧淼,胡钟升,等.IL-27在卵巢功能减退相关发病机制中的研究现状[J].重庆医科大学学报,2026,51(3):395-399.
Zhang Yue,Ma Jingmiao,Hu Zhongsheng,et al.Current research progress on IL-27 in the pathogenesis of diminished ovarian reserve[J].Journal of Chongqing Medical University,2026,51(3):395-399.
张越,马婧淼,胡钟升,等.IL-27在卵巢功能减退相关发病机制中的研究现状[J].重庆医科大学学报,2026,51(3):395-399. DOI: 10.13406/j.cnki.cyxb.003994.
Zhang Yue,Ma Jingmiao,Hu Zhongsheng,et al.Current research progress on IL-27 in the pathogenesis of diminished ovarian reserve[J].Journal of Chongqing Medical University,2026,51(3):395-399. DOI: 10.13406/j.cnki.cyxb.003994.
随着社会的发展,越来越多的女性选择晚婚晚育,导致高龄生育比例持续上升,随之出现的育龄期女性卵巢功能减退(diminished ovarian reserve,DOR)也明显增加。因此尽早地探明DOR的发病机制,做到对该病的早诊断、早治疗,就能更好地保护女性生育力。本综述总结了白细胞介素-12(interleukin 12,IL-12)家族细胞因子白细胞介素-27(interleukin 27,IL-27)在DOR发病机制中的作用和目前的临床研究现状,为DOR的诊疗提供新的临床思路。
With societal development,an increasing number of women are opting for delayed marriage and childbearing,leading to a sustained rise in the proportion of advanced maternal age. Consequently,there has been a marked increase in the incidence of diminished ovarian reserve(DOR) among women of reproductive age. Therefore,elucidating the pathogenesis of DOR at an early stage and achieving early diagnosis and treatment are crucial for better preserving female fertility. This review summarizes the role of the interleukin-12 family cytokine interleukin-27 in the pathogenesis of DOR and the current status of clinical research,providing new clinical perspectives for the diagnosis and treatment of DOR.
Ganer Herman H , Volodarsky-Perel A , Ton Nu TN , et al . Diminished ovarian reserve is a risk factor for preeclampsia and placental malperfusion lesions [J ] . Fertil Steril , 2023 , 119 ( 5 ): 794 - 801 .
Xu WD , Wang DC , Zhao M , et al . An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases [J ] . Front Immunol , 2024 , 15 : 1366377 .
卵巢储备功能减退临床诊治专家共识专家组 , 中华预防医学会生育力保护分会生殖内分泌生育保护学组 . 卵巢储备功能减退临床诊治专家共识 [J ] . 生殖医学杂志 , 2022 , 31 ( 4 ): 425 - 434 .
Expert Group of Consensus on Clinical Diagnosis & Management of Diminished Ovarian Reserve , Reproductive Endocrinology & Fertility Preservation Section of Chinese Society on Fertility Preservation under Chinese Preventive Medicine Association . Consensus on clinical diagnosis and management of diminished ovarian reserve [J ] . J Reprod Med , 2022 , 31 ( 4 ): 425 - 434 .
Song CC , Qin YY , Li Y , et al . Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice [J ] . Sci China Life Sci , 2024 , 67 ( 7 ): 1325 - 1337 .
Giambalvo S , Garaffoni C , Silvagni E , et al . Factors associated with fertility abnormalities in women with systemic lupus erythematosus:a systematic review and meta-analysis [J ] . Autoimmun Rev , 2022 , 21 ( 4 ): 103038 .
Xu MT , Li F , Xu XY , et al . Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance [J ] . Ecotoxicol Environ Saf , 2024 , 271 : 115989 .
Tian T , Wang Z , Liu F , et al . Exposure to heavy metallic and trace essential elements and risk of diminished ovarian reserve in reproductive age women:a case-control study [J ] . J Hazard Mater , 2024 , 470 : 134206 .
Zhou ZH , Li YS , Ding J , et al . Chronic unpredictable stress induces anxiety-like behavior and oxidative stress,leading to diminished ovarian reserve [J ] . Sci Rep , 2024 , 14 ( 1 ): 30681 .
Liu SH , Jia YB , Meng SR , et al . Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells:a review [J ] . Int J Mol Sci , 2023 , 24 ( 11 ): 9205 .
Yazdanpanah E , Pazoki A , Dadfar S , et al . Interleukin-27 and autoimmune disorders: a compressive review of immunological functions [J ] . Biomolecules , 2024 , 14 ( 12 ): 1489 .
Jiao X , Zhang XR , Li NY , et al . T(reg) deficiency-mediated T(H) 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells [J ] . Clin Transl Med , 2021 , 11 ( 6 ): e448 .
Li XL , Li CJ , Yang J , et al . Associations of the levels of adipokines and cytokines in individual follicles with in vitro fertilization outcomes in women with different ovarian reserves [J ] . J Ovarian Res , 2025 , 18 ( 1 ): 11 .
何瑞芬 . 转录组和代谢组联合探究卵巢储备功能减退的发病机制 [D ] . 兰州 : 兰州大学 , 2021 .
He RF . Integrating transcriptome and metabolome to reveal pathogenesis of diminished ovarian reserve [D ] . Lanzhou : Lanzhou University , 2021 .
Siniscalco ER , Craft J . IL-27 gives a good gut feeling about immune regulation [J ] . Nat Immunol , 2023 , 24 ( 12 ): 1972 - 1973 .
Zhang XY , Shen HH , Qin XY , et al . IL-27 promotes decidualization via the STAT3-ESR/PGR regulatory axis [J ] . J Reprod Immunol , 2022 , 151 : 103623 .
Zhang XY , Qin XY , Shen HH , et al . IL-27 deficiency inhibits proliferation and invasion of trophoblasts via the SFRP2/Wnt/β-catenin pathway in fetal growth restriction [J ] . Int J Med Sci , 2023 , 20 ( 3 ): 392 - 405 .
Hu XH , Zhu Q , Wang Y , et al . Newly characterized decidual Tim-3 + Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts [J ] . Hum Reprod , 2020 , 35 ( 11 ): 2454 - 2466 .
Luo YH , Zhang YY , Li MQ , et al . Emerging roles of IL-27 in trophoblast cells and pregnancy complications [J ] . Am J Reprod Immunol , 2024 , 92 ( 4 ): e13942 .
Aramesh A , Jahromi BN , Samadi M , et al . Investigating the association between IL-27 and susceptibility to preeclampsia among Iranian women [J ] . Clin Lab , 2021 , 67 ( 9 ): 34542965 .
Ma Y , Ma MY , Ye SL , et al . Association of IL-17 and IL-27 polymorphisms with susceptibility to recurrent pregnancy loss and pre-eclampsia:a systematic review and meta-analysis [J ] . Immun Inflamm Dis , 2023 , 11 ( 10 ): e1057 .
Zhao SJ , Hu XH , Lin XX , et al . IL-27/Blimp-1 axis regulates the differentiation and function of Tim-3+ Tregs during early pregnancy [J ] . JCI Insight , 2024 , 9 ( 16 ): e179233 .
Li X , Liu LP , Jiang L , et al . Serum IL-27 and GDF15 levels in second trimester are associated with adverse pregnancy outcomes [J ] . J Mol Cell Biol , 2025 , 16 ( 11 ): mjae053 .
Huang DN , Ran YX , Liu Z , et al . IL-27 mediates pro-inflammatory effects via the ERK signaling pathway during preterm labor [J ] . Front Immunol , 2021 , 12 : 709229 .
Mei YW , Ran YX , Liu Z , et al . The role of IL-27 in the systemic inflammatory response that accompanies preterm labour [J ] . Inflammation , 2022 , 45 ( 2 ): 876 - 890 .
Qiu XM , Lai ZZ , Ha SY , et al . IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis [J ] . Reproduction , 2020 , 159 ( 3 ): 251 - 260 .
Zhang XY , Wang CJ , Shen HH , et al . Impaired IL-27 signaling aggravates macrophage senescence and sensitizes premature ovarian insufficiency induction by high-fat diet [J ] . Biochim Biophys Acta Mol Basis Dis , 2024 , 1870 ( 8 ): 167469 .
Zhao YJ , Huo Z , Zhou ZZ , et al . Interleukin-27(IL-27) promotes chlamydial infection in the female genital tract [J ] . Infect Immun , 2022 , 90 ( 4 ): e00651 - 21 .
Annamanedi M , Vance JK , Robinson CM . Inhibition of IL-27 signaling regulates chemokine levels and sustains CXCR2 receptor expression on mononuclear cells to improve disease outcomes during gram-negative neonatal sepsis [J ] . Front Immunol , 2025 , 16 : 1653355 .
0
浏览量
5
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621