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1.黑龙江中医药大学基础医学院中医基础理论教研室,哈尔滨 150040
2.惠州学院生命科学学院,惠州 516007
3.黑龙江中医药大学/黑龙江省重点实验室/中医基础理论研究实验室,哈尔滨 150040
周禹含,Email:1379851507@qq.com,研究方向:中医药防治老年性疾病研究。
周妍妍,Email:13339319259@163.com。
收稿:2025-05-12,
修回:2025-06-30,
录用:2025-07-02,
纸质出版:2026-03-28
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周禹含,宋琳,吴伟东等.中药调控线粒体动力学防治阿尔茨海默病的研究进展[J].重庆医科大学学报,2026,51(03):368-375.
Zhou Yuhan,Song Lin,Wu Weidong,et al.Progress on Chinese medicine modulating mitochondrial dynamics in the prevention and treatment of Alzheimer’s disease[J].Journal of Chongqing Medical University,2026,51(03):368-375.
周禹含,宋琳,吴伟东等.中药调控线粒体动力学防治阿尔茨海默病的研究进展[J].重庆医科大学学报,2026,51(03):368-375. DOI: 10.13406/j.cnki.cyxb.003959.
Zhou Yuhan,Song Lin,Wu Weidong,et al.Progress on Chinese medicine modulating mitochondrial dynamics in the prevention and treatment of Alzheimer’s disease[J].Journal of Chongqing Medical University,2026,51(03):368-375. DOI: 10.13406/j.cnki.cyxb.003959.
阿尔茨海默病(Alzheimer’s disease,AD)是以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变。线粒体通过裂变和融合调节自身的形态、数量及大小的生理过程被称为“线粒体动力学”,这一过程能够通过调节突触功能、神经炎症、氧化应激等过程影响AD病理发展。近年来,中药在AD治疗的应用日益广泛,且在维持线粒体动力学稳态方面展现出显著优势,其中多种中药单体及中药复方可作用于线粒体裂变蛋白及线粒体融合蛋白以平衡线粒体的裂变和融合过程,使线粒体具有稳定的超微结构及数量,并通过减轻神经元损伤、抑制细胞凋亡、调节能量代谢等途径,发挥对AD的防治作用。目前,中药调控线粒体动力学防治AD的基础实验取得了一定成果,但尚缺乏系统性总结,故本综述概括了近5年相关文献,以期为未来AD的临床治疗提供理论参考。
Alzheimer’s disease(AD) is a degenerative disease of the central nervous system characterized by progressive cognitive dysfunction and behavioral impairment. Mitochondrial dynamics refers to the physiological process by which mitochondria undergo fission and fusion to alter their shape,number,and size,which can affect the pathological development of AD by regulating synaptic function,neuroinflammation,and oxidative stress. In recent years,the increasing application of traditional Chinese medicine in the treatment of AD has shown notable advantages in maintaining the homeostasis of mitochondrial dynamics. A variety of monomers and combinations of traditional Chinese medicine act on mitochondrial fission and fusion proteins to balance the fission and fusion processes to achieve a stable status in the ultrastructure and number of mitochondria,thereby playing a protective role against AD through mitigating neuronal damage,inhibiting cell apoptosis,and regulating energy metabolism. Achievements have been made in basic experiments on using traditional Chinese medicine to regulate mitochondrial dynamics to prevent and control AD,but systematic summaries are lacking. This review of relevant literature in recent five years aims to provide a theoretical reference for the clinical treatment of AD in the future.
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