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1.四川省第二中医医院药学部,成都 610031
2.重庆医科大学基础医学院生理学教研室,重庆 400016
张晓娟,Email:67870885@qq.com,研究方向:药物靶标与新药研发。
陈显军,Email:chenxianjun@cqmu.edu.cn。
收稿:2025-03-29,
修回:2025-05-18,
录用:2025-05-30,
纸质出版:2025-10-28
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张晓娟,陈瑶,张超,等.氯马斯汀调控少突胶质细胞髓鞘修复的机制研究进展[J].重庆医科大学学报,2025,50(10):1323-1328.
Zhang Xiaojuan,Chen Yao,Zhang Chao,et al.Research advances in the mechanism of clemastine regulating oligodendrocytes and remyelination[J].Journal of Chongqing Medical University,2025,50(10):1323-1328.
张晓娟,陈瑶,张超,等.氯马斯汀调控少突胶质细胞髓鞘修复的机制研究进展[J].重庆医科大学学报,2025,50(10):1323-1328. DOI: 10.13406/j.cnki.cyxb.003928.
Zhang Xiaojuan,Chen Yao,Zhang Chao,et al.Research advances in the mechanism of clemastine regulating oligodendrocytes and remyelination[J].Journal of Chongqing Medical University,2025,50(10):1323-1328. DOI: 10.13406/j.cnki.cyxb.003928.
少突胶质细胞(oligodendrocyte,OL)在中枢神经系统中发挥着关键作用,其形成的髓鞘对于维持神经系统的正常功能至关重要。髓鞘受损会引发多种神经系统疾病,严重影响患者的生活质量。氯马斯汀作为一种传统的抗组胺药物,近年来在“老药新用”方面展现出潜力,其能够促进髓鞘修复。本文旨在总结氯马斯汀作用于OL膜上的受体、调控细胞内关键信号通路以及核内表观遗传修饰等方式,在多个层面参与调控OL的分化、成熟、衰老和凋亡。深入探究氯马斯汀对OL的作用机制,有助于为药物治疗髓鞘退化相关疾病提供新靶点、新途径。
Oligodendrocytes(OLs) play a crucial role in the central nervous system,and the myelin sheath formed by them is essential for maintaining the normal function of the nervous system. Damage to the myelin sheath can trigger various nervous system diseases,which seriously affect the quality of life of patients. Clemastine,a traditional antihistamine,has shown certain potential in “repurposing old drugs” in recent years and can promote the repair of myelin sheath. This article summarizes the role of clemastine in regulating the differentiation,maturation,senescence,and apoptosis of OLs at multiple levels by acting on receptors on the OL membrane and regulating the key signaling pathways in cells and epigenetic modifications in the nucleus. A deeper understanding of the mechanism of action of clemastine in OLs can help to provide new targets and new approaches for drug treatment of myelin-degenerative diseases.
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