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1.甘肃省中医院口腔颌面外科,兰州 730050
2.兰州康美口腔医院种植科,兰州 730030
3.广东健齿生物科技有限公司,广州 510000
4.兰州大学口腔医院正畸科,兰州 730030
赵弼洲,Email:zhaobizhou@126.com,研究方向:口腔牙、颅颌面畸形的研究与诊治。
田佳灵,Email:tianjialing2009@163.com。
收稿:2024-12-10,
修回:2025-03-31,
录用:2025-04-03,
纸质出版:2025-12-28
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赵弼洲,罗海霞,党晓兵等.3D打印个性化钛网的GBR术及PRF/Bio-Oss复合物修复牙槽骨缺损的应用[J].重庆医科大学学报,2025,50(12):1729-1736.
Zhao Bizhou,Luo Haixia,Dang Xiaobing,et al.Application of 3D-printed personalized titanium mesh and PRF/Bio-Oss composites in GBR surgery for the repair of alveolar bone defects[J].Journal of Chongqing Medical University,2025,50(12):1729-1736.
赵弼洲,罗海霞,党晓兵等.3D打印个性化钛网的GBR术及PRF/Bio-Oss复合物修复牙槽骨缺损的应用[J].重庆医科大学学报,2025,50(12):1729-1736. DOI: 10.13406/j.cnki.cyxb.003847.
Zhao Bizhou,Luo Haixia,Dang Xiaobing,et al.Application of 3D-printed personalized titanium mesh and PRF/Bio-Oss composites in GBR surgery for the repair of alveolar bone defects[J].Journal of Chongqing Medical University,2025,50(12):1729-1736. DOI: 10.13406/j.cnki.cyxb.003847.
目的
2
探讨3D打印个性化钛网的引导骨再生(guided bone regeneration,GBR)术及富血小板纤维蛋白(platelet-rich fibrin,PRF)/Bio-Oss复合物修复牙槽骨缺损的应用。
方法
2
纳入2021年3月至2024年2月于甘肃省中医院口腔颌面外科行GBR骨增量手术的牙槽骨缺损患者68例,随机分为3D组(
n
=34)与传统组(
n
=34),3D组使用3D打印个性化钛网及PRF/Bio-Oss复合物,传统组使用传统钛网及PRF/Bio-Oss复合物。对比2组术后2、4、6个月的牙槽骨增加高度、宽度、体积及并发症发生率。
结果
2
3D组术后2、4、6个月的牙槽骨增加高度、宽度与传统组相比,但差异均无统计学意义(
P
>
0.05)。3D组术后2个月、4个月的牙槽骨增加体积均高于传统组,但差异均无统计学意义(
P
>
0.05),术后6个月时牙槽骨增加体积显著高于传统组(
P
<
0.05)。3D组发生早期暴露、晚期暴露、总暴露、创口感染的比例均低于传统组,但差异均无统计学意义(
P
>
0.05)。
结论
2
3D打印个性化钛网及PRF/Bio-Oss复合物的GBR术修复牙槽骨缺损效果良好,术后6个月骨增加体积显著高于应用传统钛网的GBR术,且不影响其安全性,值得临床推广应用。
Objective
2
To explore the application of 3D-printed personalized titanium mesh in guided bone regeneration(GBR) surgery and the repair of alveolar bone defects using platelet-rich fibrin(PRF)/Bio-Oss composites.
Methods
2
A total of 68 patients with alveolar bone defects who underwent GBR bone augmentation surgery at Department of Oral and Maxillofacial Surgery, Gansu Provincial Hospital of Traditional Chinese Medicine between March 2021 and February 2024 were enrolled in the study and randomly assigned to either the 3D group(
n
=34) or the traditional group(
n
=34). The 3D group was treated with 3D-printed personalized titanium mesh and PRF/Bio-Oss composites,while the traditional group received conventional titanium mesh and PRF/Bio-Oss composites. The increases in height,width,volume of alveolar bone and the incidence of complications at 2,4,and 6 months postoperatively were compared betwee
n the two groups.
Results
2
The increases in height and width of alveolar bone at 2,4,and 6 months postoperatively in the 3D group were higher than those in the traditional group,but the differences were not statistically significant(
P
>
0.05). The increases in alveolar bone volume at 2 and 4 months postoperatively in the 3D group were higher than those in the traditional group,but the differences were not statistically significant(
P
>
0.05). At 6 months postoperatively,the increase in alveolar bone volume was significantly higher than that in the traditional group(
P
<
0.05). The proportions of early exposure,late exposure,total exposure,and wound infection in the 3D group were all lower than those in the traditional group,but the differences were not statistically significant(
P
>
0.05).
Conclusion
2
The GBR surgery using 3D-printed personalized titanium mesh and PRF/Bio-Oss composites demonstrated favorable outcomes in the repair of alveolar bone defects. At 6 months postoperatively,this approach resulted in a significantly greater increase in alveolar bone volume compared to the use of conventional titanium mesh in GBR surgery,without compromising safety. These findings support its potential for broader clinical application and promotion.
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