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1.重庆市中医药学院第一附属医院肝病科,重庆 400021
2.重庆医科大学附属第二医院心血管内科,重庆 401336
3.重庆市中医药学院第一附属医院心血管内科,重庆 400021
刘宇行,Email:lyhdoc2020@163.com,研究方向:病毒性肝炎及肝硬化的研究和治疗。
龙 毅,Email:619036254@qq.com 。
收稿:2024-12-03,
修回:2025-03-17,
录用:2025-03-25,
纸质出版:2025-06-28
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刘宇行,易鑫,龙毅.代谢相关脂肪性肝病对高血压患者冠心病发生的影响[J].重庆医科大学学报,2025,50(6):834-842.
Liu Yuhang,Yi Xin,Long Yi.Influence of metabolic-associated fatty liver disease on the development of coronary artery disease in patients with hypertension[J].Journal of Chongqing Medical University,2025,50(6):834-842.
刘宇行,易鑫,龙毅.代谢相关脂肪性肝病对高血压患者冠心病发生的影响[J].重庆医科大学学报,2025,50(6):834-842. DOI: 10.13406/j.cnki.cyxb.003830.
Liu Yuhang,Yi Xin,Long Yi.Influence of metabolic-associated fatty liver disease on the development of coronary artery disease in patients with hypertension[J].Journal of Chongqing Medical University,2025,50(6):834-842. DOI: 10.13406/j.cnki.cyxb.003830.
目的
2
探讨代谢相关脂肪性肝病(metabolic-associated fatty liver disease,MAFLD)对高血压(hypertension,HT)患者冠心病(coronary artery disease,CAD)发生的影响。
方法
2
收集2011年11月至2021年11月,于重庆医科大学附属第二医院及重庆医科大学附属大学城医院住院HT合并MAFLD患者5 344例,同期纳入HT无MAFLD患者5 344例为对照组。对2组患者临床资料进行统计分析。
结果
2
HT合并MAFLD组与对照组的年龄分别为(62.6±12.4)岁和(69.1±11.9)岁,CAD发生率分别为1 931例(36.1%)和1 542例(28.9%),组间比较差异均有统计学意义(均
P
<
0.05)。多因素分析发现MAFLD、年龄、吸烟、糖尿病、左室射血分数、总胆固醇均为影响HT患者CAD形成的重要预测因素,其OR值分别为2.033、1.050、1.429、1.157、0.983和1.078。经过调整不同混杂因素建立5个回归模型发现MAFLD是HT患者发生CAD的独立危险因素(
P<
0.05)。
结论
2
HT伴MAFLD患者CAD患病率高,MAFLD是HT患者发生CAD的独立危险因素。
Objective
2
To investigate the influence of metabolic-associated fatty liver disease (MAFLD) on the development of coronary artery disease(CAD) in patients with hypertension(HT).
Methods
2
A total of 5 344 patients with HT and MAFLD who were hospitalized in The Second Affiliated Hospital of Chongqing Medical University and University-Town Hospital of Chongqing Medical University from November 2011 to November 2021 were enrolled as HT+MAFLD group,and 5 344 HT patients without MAFLD who were hospitalized during the same period of time were enrolled as control group. Clinical data were analyzed for both groups.
Results
2
There were significant differences between the HT+MAFLD group and the control group in age(62.6±12.4 years vs.
69.1±11.9 years,
P
<
0.05) and the incidence rate of CAD[1 931(36.1%) vs. 1 542 (28.9%),
P
<
0.05]. The multivariate logistic regression analysis showed that MAFLD,age,smoking,type 2 diabetes,left ventricular ejection fraction,and total cholesterol were important predictive factors for CAD in HT patients,with an odds ratio of 2.033,1.050,1.429,1.157,0.983,and 1.078,respectively. After adjustment for related confounding factors,five regression models were established,and the results showed that MAFLD was an independent risk factor for the development of CAD in HT patients.
Conclusion
2
HT patients with MAFLD tend to have a relatively high prevalence rate of CAD,and MAFLD is an independent risk factor for the development of CAD in HT patients.
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