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1.黑龙江中医药大学研究生院,哈尔滨 150040
2.黑龙江中医药大学附属第一医院妇科二科,哈尔滨 150000
任佳杰,Email:18435209016@163.com,研究方向:中医药防治妇科疾病。
冯晓玲,Email:doctorfxl@163.com。
收稿:2024-04-25,
修回:2024-07-15,
录用:2024-07-22,
纸质出版:2024-11-28
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任佳杰,胡蝶,刘佳宁,等.细胞衰老与妊娠[J].重庆医科大学学报,2024,49(11):1361-1366.
Ren Jiajie,Hu Die,Liu Jianing,et al.Cellular senescence and pregnancy[J].Journal of Chongqing Medical University,2024,49(11):1361-1366.
任佳杰,胡蝶,刘佳宁,等.细胞衰老与妊娠[J].重庆医科大学学报,2024,49(11):1361-1366. DOI: 10.13406/j.cnki.cyxb.003625.
Ren Jiajie,Hu Die,Liu Jianing,et al.Cellular senescence and pregnancy[J].Journal of Chongqing Medical University,2024,49(11):1361-1366. DOI: 10.13406/j.cnki.cyxb.003625.
细胞衰老是一种应激诱导的终末细胞周期停滞程序。衰老在许多生理和病理条件下的影响已经很明显。研究表明,细胞衰老在健康妊娠的发展和进展中起着决定性的作用。母胎组织(蜕膜和胎盘)的过早衰老与许多不良妊娠结局有关,包括复发性流产、复发性植入失败、胎儿生长受限和子痫前期。本文结合最新相关文献,综述细胞衰老及其与正常妊娠进展和不良妊娠结局的关系。
Cellular senescence involves a stress-induced program that leads to terminal cell cycle arrest. The effects of senescence are evident in many physiological and pathological conditions. Studies have shown that cellular senescence plays a decisive role in the development and progression of a healthy pregnancy. Premature senescence of maternal and fetal tissues(decidua and placenta) is associated with many adverse pregnancy outcomes,including recurrent miscarriages,recurrent implantation failures,fetal growth restriction,and pre-eclampsia. This article provides a thorough review of cellular senescence and its relation to normal pregnancy progression and adverse pregnancy outcomes through a comprehensive analysis of the latest literature on the topic.
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