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1.成都市第二人民医院全科医学科,成都 610012
2.成都市第二人民医院心内科,成都 610012
3.四川大学华西公共卫生学院流行病与卫生统计学系,成都 610041
4.成都市第二人民医院神经内科,成都 610012
张兴平,Email:194955495@qq.com,研究方向:慢性病的诊治。
收稿:2024-05-30,
修回:2024-06-24,
录用:2024-07-02,
纸质出版:2024-07-28
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张兴平,黄晓波,杜娟,等.中国农村中老年人群体力活动不足与认知障碍发生风险的相关性研究[J].重庆医科大学学报,2024,49(7):919-924.
Zhang Xingping,Huang Xiaobo,Du Juan,et al.Association between insufficient physical activity and the risk of cognitive impairment in middle-aged and elderly people in rural China[J].Journal of Chongqing Medical University,2024,49(7):919-924.
张兴平,黄晓波,杜娟,等.中国农村中老年人群体力活动不足与认知障碍发生风险的相关性研究[J].重庆医科大学学报,2024,49(7):919-924. DOI: 10.13406/j.cnki.cyxb.003549.
Zhang Xingping,Huang Xiaobo,Du Juan,et al.Association between insufficient physical activity and the risk of cognitive impairment in middle-aged and elderly people in rural China[J].Journal of Chongqing Medical University,2024,49(7):919-924. DOI: 10.13406/j.cnki.cyxb.003549.
目的
2
基于具有全国代表性的队列研究数据,探讨我国农村地区45岁以上中老年人群体力活动不足与认知障碍发生风险之间的相关性。
方法
2
应用中国健康与养老追踪调查2011年、2013年、2015年、2018年和2020年的纵向研究数据进行分析。体力活动根据《中国人群身体活动指南(2021)》推荐的活动量作为标准,将体力活动水平分为体力活动不足和体力活动充分。认知障碍根据4个维度即定向、计算、记忆和绘画进行测量,总分低于年龄组标准的1个标准差为认知障碍。比较不同体力活动水平人群的认知障碍发生率,采用Cox比例风险回归模型分析体力活动不足与认知障碍发生风险之间的相关性。
结果
2
共纳入2011年基线1 904例研究对象,其中体力活动不足者546例(28.7%),体力活动充足者1 358例(71.3%)。研究对象累计随访12 001人年,平均随访(6.3±2.8)年,随访期间共有324例出现认知障碍,总发病密度为2.70/100人年。其中,体力活动充足者发病密度为2.38/100人年,体力活动不足者发病密度为3.56/100人年(
P
<
0.001)。多因素Cox比例风险回归分析显示:体力活动不足者较体力活动充足者认知障碍发生风险增加33%(
HR
=1.33,95%CI=1.05~1.69)。
结论
2
中国农村地区中老年人人群中,体力活动不足增加了认知障碍发生风险。建议采取充分的体力活动,减少或延缓认知功能障碍的发生发展。
Objective
2
To investigate the association between insufficient physical activity and cognitive impairment in middle-aged and elderly people,aged 45 years or older,in rural China based on data from the nationally representative large-scale longitudinal study.
Methods
2
The data from China Health and Retirement Longitudinal Study(CHARLS) in 2011,2013,2015,2018,and 2020 were used for analysis. According to Physical Activity Guidelines for Chinese(2021),the level of physical activity was classified into insufficient physical activity and sufficient physical activity. Cognitive function was measured based on the four dimensions of orientation,computation,memory,and drawing,and cognitive impairment was defined as a total score of at least 1 standard deviation(SD) below the age standard. The incidence rate of cognitive impairment was compared between the populations with different levels of physical activity,and the
Cox
proportional-hazards regression model was used to analyze the association between insufficient physical activity and cognitive impairment.
Results
2
A total of 1904 subjects were included from the CHARLS national baseline survey in 2011,among whom 546(28.7
%) had insufficient physical activity and 1358(71.3%) had sufficient physical activity. The subjects were followed up for 12001 person-years,with a mean follow-up time of (6.3±2.8) years,and during this period of time,324 subjects developed cognitive impairment,with a total incidence density of 2.70/100 person-years. The incidence density of cognitive impairment was 2.38/100 person-years in the subjects with sufficient physical activity and 3.56/100 person-years in those with insufficient physical activity(
P
<
0.001). The multivariate
Cox
proportional-hazards regression analysis showed that the risk of cognitive impairment in the subjects with insufficient physical activity was increased by 33% compared with that in the subjects with sufficient physical activity(hazard ratio=1.33,95% confidence interval:1.05-1.69).
Conclusion
2
Insufficient physical activity increases the risk of cognitive impairment among middle-aged and elderly adults in rural areas of China,and it is recommended that middle-aged and elderly people take sufficient physical activity to effectively reduce or delay the development and progression of cognitive impairment.
Jia LF , Du YF , Chu L , et al . Prevalence,risk factors,and management of dementia and mild cognitive impairment in adults aged 60 years or older in China:a cross-sectional study [J ] . Lancet Public Health , 2020 , 5 ( 12 ): e661 - e671 .
Jia LF , Quan MN , Fu Y , et al . Dementia in China:epidemiology,clinical management,and research advances [J ] . Lancet Neurol , 2020 , 19 ( 1 ): 81 - 92 .
中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会 . 2018中国痴呆与认知障碍诊治指南(七):阿尔茨海默病的危险因素及其干预 [J ] . 中华医学杂志 , 2018 , 98 ( 19 ): 1461 - 1466 .
Guidelines for the diagnosis and treatment of dementia and cognitive impairment in China in 2018 (VII):Risk factors of Alzheimer’s Harmo’s disease and its intervention [J ] . Natl Med J China ,2018, 98 ( 19 ): 1461 - 1466 .
Suzuki T , Shimada H , Makizako H , et al . A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment [J ] . PLoS One , 2013 , 8 ( 4 ): e61483 .
Zhu JW , Ge FF , Zeng Y , et al . Physical and mental activity,disease susceptibility,and risk of dementia:a prospective cohort study based on UK biobank [J ] . Neurology , 2022 , 99 ( 8 ): e799 - e813 .
Zhao Y , Hu Y , Smith JP , et al . Cohort profile: the China Health and Retirement Longitudinal Study(CHARLS) [J ] . Int J Epidemiol , 2014 , 43 ( 1 ): 61 - 68 .
Zhao YH , Hu YS , Smith JP , et al . Cohort profile:the China health and retirement longitudinal study(CHARLS) [J ] . Int J Epidemiol , 2014 , 43 ( 1 ): 61 - 68
中国营养学会肥胖防控分会 , 中国营养学会临床营养分会 , 中华预防医学会行为健康分会 , 等 . 中国居民肥胖防治专家共识 [J ] . 中国预防医学杂志 , 2022 , 8 ( 5 ): 321 - 339 .
Obesity Prevention and Control Branch of the Chinese Nutrition Society , Clinical Nutrition Branch of the Chinese Nutrition Society , Behavioral Health Branch of the Chinese Preventive Medicine Association , etc . Expert Consensus on Obesity Prevention and Control among Chinese Residents [J ] . Chinese Journal of Preventive Medicine , 2022 , 8 ( 5 ): 321 - 339
中国高血压防治指南修订委员会 , 高血压联盟 . 中国高血压防治指南(2018年修订版) [J ] . 中国心血管杂志 , 2019 , 24 ( 1 ): 24 - 56 .
Chinese guidelines for the management of hypertensionWriting Group of 2018 [J ] . Chin J Cardiovasc Med , 2019 , 24 ( 1 ): 24 - 56 .
中华医学会糖尿病学分会 . 中国2型糖尿病防治指南(2020年版)(上) [J ] . 中国实用内科杂志 , 2021 , 41 ( 8 ): 668 - 695 .
Guideline for the prevention and treatment of type 2 diabetes mellitus in China( 2020 edition)(Part 1) [J ] . Chin J Pract Intern Med , 2021 , 41 ( 8 ): 668 - 695 .
王增武 , 刘 静 , 李建军 , 等 . 中国血脂管理指南(2023年) [J ] . 中国循环杂志 , 2023 , 38 ( 3 ): 237 - 271 .
Wang ZW , Liu J , Li JJ , et al . Chinese Blood Lipid Management Guidelines(2023) [J ] . Chinese Journal of Circulation , 2023 , 38 ( 3 ): 237 - 271 .
Jiang HY , Zhang SM , Yao XC , et al . Does physical activity attenuate the association between ambient PM 2.5 and physical function? [J ] . Sci Total Environ , 2023 , 874 : 162501 .
赵文华 , 李可基 , 王玉英 , 等 . 中国人群身体活动指南(2021) [J ] . 中国公共卫生 , 2022 , 38 ( 2 ): 129 - 130 .
Zhao WH , Li KJ , Wang YY , et al . Physical Activity Guidelines for the Chinese Population(2021) [J ] . China Public Health , 2022 , 38 ( 2 ): 129 - 130
Hu YS , Peng WJ , Ren RJ , et al . Sarcopenia and mild cognitive impairment among elderly adults:the first longitudinal evidence from CHARLS [J ] . J Cachexia Sarcopenia Muscle , 2022 , 13 ( 6 ): 2944 - 2952 .
Sofi F , Valecchi D , Bacci D , et al . Physical activity and risk of cognitive decline: a meta-analysis of prospective studies [J ] . Inter Med , 2011 , 269 ( 1 ): 107 - 117 .
Hamer M , Chida Y . Physical activity and risk of neurodegenerative disease:a systematic review of prospective evidence [J ] . Psychol Med , 2009 , 39 ( 1 ): 3 - 11 .
张永珍 , 岳寿伟 . 从久坐到运动:生活方式对脑健康的影响及相关机制探讨 [J ] . 中华物理医学与康复杂志 , 2021 , 7 ( 10 ): 939 - 942 .
Zhang YZ,Yue Shou W From Sedentary to Exercise: The Impact of Lifestyle on Brain Health and Related Mechanisms [J ] . Chinese Journal of Physical Medicine and Rehabilitation , 2021 , 7 ( 10 ): 939 - 942
Pan XF , Wang LM , Pan A . Epidemiology and determinants of obesity in China [J ] . Lancet Diabetes Endocrinol , 2021 , 9 ( 6 ): 373 - 392 .
Qi M , Zhu Y , Zhang L , et al . The effect of aerobic dance intervention on brain spontaneous activity in older adults with mild cognitive impairment:a resting-state functional MRI study [J ] . Exp Ther Med , 2019 , 17 ( 1 ): 715 - 722 .
ten Brinke LF , Bolandzadeh N , Nagamatsu LS , et al . Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment:a 6-month randomised controlled trial [J ] . Br J Sports Med , 2015 , 49 ( 4 ): 248 - 254 .
Brown BM , Peiffer J , Rainey-Smith SR . Exploring the relationship between physical activity,beta-amyloid and tau:a narrative review [J ] . Ageing Res Rev , 2019 , 50 : 9 - 18 .
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