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重庆医科大学附属第一医院重症医学科,重庆 400016
王金戈,Email:903707670@qq.com,研究方向:血液净化在脓毒症治疗中的应用。
范 晶,Email:286445733@qq.com。
收稿:2024-01-12,
修回:2024-03-24,
录用:2024-04-02,
纸质出版:2024-04-28
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王金戈,徐昉,范晶.血浆炎性因子吸附在脓毒症治疗中的应用研究进展[J].重庆医科大学学报,2024,49(4):370-375.
Wang Jinge,Xu Fang,Fan Jing.Research progress of plasma inflammatory cytokine adsorption in the treatment of sepsis[J].Journal of Chongqing Medical University,2024,49(4):370-375.
王金戈,徐昉,范晶.血浆炎性因子吸附在脓毒症治疗中的应用研究进展[J].重庆医科大学学报,2024,49(4):370-375. DOI: 10.13406/j.cnki.cyxb.003479.
Wang Jinge,Xu Fang,Fan Jing.Research progress of plasma inflammatory cytokine adsorption in the treatment of sepsis[J].Journal of Chongqing Medical University,2024,49(4):370-375. DOI: 10.13406/j.cnki.cyxb.003479.
脓毒症和脓毒性休克是重症监护室常见病种,全球每年有超过1 800万严重脓毒症病例。国外流行病学调查显示,脓毒症的病死率已经超过心肌梗死,成为重症监护室非心脏病人的死亡主要原因。医学的进步带来越来越多治疗脓毒症的创新治疗方式,连续血液净化逐渐成为脓毒症患者早期治疗的重要手段,同时体外血液吸附在脓毒症患者中的治疗价值也逐渐受到重视。本文旨在总结近些年血浆炎性因子吸附在脓毒症治疗中应用的研究进展,对现有研究报道或已在临床应用的常见的几种体外血液吸附技术及其相关研究进展进行总结,以期为更好认识其在临床治疗中的运用价值及对预后的改善提供参考,从而为脓毒症及脓毒症休克患者治疗提供帮助。
Sepsis and septic shock are common in intensive care units,with more than 18 million cases of severe sepsis worldwide each year. According to the epidemiological survey abroad,the case fatality rate of sepsis has exceeded that of myocardial infarction, so sepsis has become the main cause of death of non-cardiac patients in intensive care units. Medical advances have led to more and more innovative treatments for sepsis. Continuous blood purification is gradually emerging as a crucial early treatment modality for septic patients,while extracorporeal blood adsorption is also gaining attention for its therapeutic value in septic patients. This article aims to summarize the research progress of plasma inflammatory cytokine adsorption in the treatment of sepsis in recent years, as well as the common extracorporeal blood adsorption techniques that have been reported in existing research or applied clinically along with their research advances,thus providing a reference for better understanding its application value in clinical treatment and improving the prognosis,and offering help for the treatment of patients with sepsis and septic shock.
Rudd KE , Johnson SC , Agesa KM , et al . Global,regional,and national sepsis incidence and mortality,1990-2017:analysis for the Global Burden of Disease Study [J ] . Lancet , 2020 , 395 ( 10219 ): 200 - 211 .
Xie JF , Wang HL , Kang Y , et al . The epidemiology of sepsis in Chinese ICUs : a national cross-sectional survey [J ] . Crit Care Med , 2020 , 48 ( 3 ): e209 - e218 .
Singer M , Deutschman CS , Seymour CW , et al . The third international consensus definitions for sepsis and septic shock(sepsis-3) [J ] . JAMA , 2016 , 315 ( 8 ): 801 - 810 .
Chousterman BG , Swirski FK , Weber GF . Cytokine storm and sepsis disease pathogenesis [J ] . Semin Immunopathol , 2017 , 39 ( 5 ): 517 - 528 .
范臻佳 , 刘 禹 , 许冠群 , 等 . 华法林抗凝治疗患者维生素K依赖性凝血因子、蛋白C及蛋白S活性改变的分析 [J ] . 诊断学理论与实践 , 2022 , 21 ( 3 ): 362 - 366 .
Fan ZJ , Liu Y , Xu GQ , et al . The analysis of activities of vitamin K-dependent coagulation factors,protein C and protein S in patients on warfarin therapy [J ] . J Diagn Concepts Pract , 2022 , 21 ( 3 ): 362 - 366 .
Schultz P , Schwier E , Eickmeyer C , et al . High-dose CytoSorb hemoadsorption is associated with improved survival in patients with septic shock:a retrospective cohort study [J ] . J Crit Care , 2021 , 64 : 184 - 192 .
Kaçar CK , Uzundere O , Kandemir D , et al . Efficacy of HA330 hemoperfusion adsorbent in patients followed in the intensive care unit for septic shock and acute kidney injury and treated with continuous venovenous hemodiafiltration as renal replacement therapy [J ] . Blood Purif , 2020 , 49 ( 4 ): 448 - 456 .
Schwindenhammer V , Girardot T , Chaulier K , et al . oXiris ® use in septic shock:experience of two French centres [J ] . Blood Purif , 2019 , 47 ( Suppl 3 ): 1 - 7 .
Brouwer WP , Duran S , Kuijper M , et al . Hemoadsorption with CytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock:a propensity-score-weighted retrospective study [J ] . Crit Care , 2019 , 23 ( 1 ): 317 .
Broman ME , Hansson F , Vincent JL , et al . Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock:a randomized crossover double-blind study [J ] . PLoS One , 2019 , 14 ( 8 ): e0220444 .
Bone RC . The pathogenesis of sepsis [J ] . Ann Intern Med , 1991 , 115 ( 6 ): 457 - 469 .
Hotchkiss RS , Monneret G , Payen D . Sepsis-induced immunosuppression:from cellular dysfunctions to immunotherapy [J ] . Nat Rev Immunol , 2013 , 13 ( 12 ): 862 - 874 .
Otto GP , Sossdorf M , Claus RA , et al . The late phase of sepsis is characterized by an increased microbiological burden and death rate [J ] . Crit Care , 2011 , 15 ( 4 ): R183 .
Monneret G , Lepape A , Voirin N , et al . Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock [J ] . Intensive Care Med , 2006 , 32 ( 8 ): 1175 - 1183 .
Stearns-Kurosawa DJ , Osuchowski MF , Valentine C , et al . The pathogenesis of sepsis [J ] . Annu Rev Pathol , 2011 , 6 : 19 - 48 .
Cohen J . The immunopathogenesis of sepsis [J ] . Nature , 2002 , 420 ( 6917 ): 885 - 891 .
Ronco C , Ricci Z . Renal replacement therapies:physiological review [J ] . Intensive Care Med , 2008 , 34 ( 12 ): 2139 - 2146 .
Ronco C , Tetta C , Mariano F , et al . Interpreting the mechanisms of continuous renal replacement therapy in sepsis:the peak concentration hypothesis [J ] . Artif Organs , 2003 , 27 ( 9 ): 792 - 801 .
Honoré PM , Matson JR . Extracorporeal removal for sepsis:acting at the tissue level:the beginning of a new era for this treatment modality in septic shock [J ] . Crit Care Med , 2004 , 32 ( 3 ): 896 - 897 .
Peng ZY , Singbartl K , Simon P , et al . Blood purification in sepsis:a new paradigm [J ] . Contrib Nephrol , 2010 , 165 : 322 - 328 .
Gaestel M , Nebreda AR , Yaffe MB . Cytokine storm [J ] . N Engl J Med , 2021 , 384 ( 16 ): e59 .
Clark WR , Ferrari F , La Manna G , et al . Extracorporeal sorbent technologies:basic concepts and clinical application [J ] . Contrib Nephrol , 2017 , 190 : 43 - 57 .
Kellum JA , Kong L , Fink MP , et al . Understanding the inflammatory cytokine response in pneumonia and sepsis:results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study [J ] . Arch Intern Med , 2007 , 167 ( 15 ): 1655 - 1663 .
Dellinger RP , Bagshaw SM , Antonelli M , et al . Effect of targeted polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level:the EUPHRATES randomized clinical trial [J ] . JAMA , 2018 , 320 ( 14 ): 1455 - 1463 .
Yamashita C , Moriyama K , Hasegawa D , et al . Evidence and perspectives on the use of polymyxin B-immobilized fiber column hemoperfusion among critically ill patients [J ] . Contrib Nephrol , 2018 , 196 : 215 - 222 .
Pfalzgraff A , Weindl G . Intracellular lipopolysaccharide sensing as a potential therapeutic target for sepsis [J ] . Trends Pharmacol Sci , 2019 , 40 ( 3 ): 187 - 197 .
Cutuli SL , Grieco DL , de Pascale G , et al . Hemadsorption [J ] . Curr Opin Anaesthesiol , 2021 , 34 ( 2 ): 113 - 118 .
Malard B , Lambert C , Kellum JA . In vitro comparison of the adsorption of inflammatory mediators by blood purification devices [J ] . Intensive Care Med Exp , 2018 , 6 ( 1 ): 12 .
Honore PM , Hoste E , Molnár Z , et al . Cytokine removal in human septic shock:where are we and where are we going? [J ] . Ann Intensive Care , 2019 , 9 ( 1 ): 56 .
Shum HP , Chan KC , Kwan MC , et al . Application of endotoxin and cytokine adsorption haemofilter in septic acute kidney injury due to Gram-negative bacterial infection [J ] . Hong Kong Med J , 2013 , 19 ( 6 ): 491 - 497 .
Monard C , Rimmelé T , Ronco C . Extracorporeal blood purification therapies for sepsis [J ] . Blood Purif , 2019 , 47 ( Suppl 3 ): 1 - 14 .
Zhai YP , Pan JY , Zhang CY . The application value of oXiris-endotoxin adsorption in sepsis [J ] . Am J Transl Res , 2021 , 13 ( 4 ): 3839 - 3844 .
Krenn CG , Steltzer H . Hemoadsorption for blood purification-incomparability of clinically available procedures [J ] . Med Klin Intensivmed Notfmed , 2021 , 116 ( 5 ): 449 - 453 .
Huang Z , Wang SR , Su W , et al . Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column [J ] . Ther Apher Dial , 2010 , 14 ( 6 ): 596 - 602 .
He ZJ , Lu HY , Jian XH , et al . The efficacy of resin hemoperfusion cartridge on inflammatory responses during adult cardiopulmonary bypass [J ] . Blood Purif , 2022 , 51 ( 1 ): 31 - 37 .
Huang Z , Wang SR , Yang ZL , et al . Effect on extrapulmonary sepsis-induced acute lung injury by hemoperfusion with neutral microporous resin column [J ] . Ther Apher Dial , 2013 , 17 ( 4 ): 454 - 461 .
Sazonov V , Abylkassov R , Tobylbayeva Z , et al . Case series:efficacy and safety of hemoadsorption with HA-330 adsorber in septic pediatric patients with cancer [J ] . Front Pediatr , 2021 , 9 : 672260 .
Gruda MC , Ruggeberg KG , O’Sullivan P , et al . Broad adsorption of sepsis-related PAMP and DAMP molecules,mycotoxins,and cytokines from whole blood using CytoSorb ® sorbent porous polymer beads [J ] . PLoS One , 2018 , 13 ( 1 ): e0191676 .
Peng ZY , Carter MJ , Kellum JA . Effects of hemoadsorption on cytokine removal and short-term survival in septic rats [J ] . Crit Care Med , 2008 , 36 ( 5 ): 1573 - 1577 .
Hetz H , Berger R , Recknagel P , et al . Septic shock secondary to β-hemolytic streptococcus-induced necrotizing fasciitis treated with a novel cytokine adsorption therapy [J ] . Int J Artif Organs , 2014 , 37 ( 5 ): 422 - 426 .
Houschyar KS , Pyles MN , Rein S , et al . Continuous hemoadsorption with a cytokine adsorber during sepsis - a review of the literature [J ] . Int J Artif Organs , 2017 , 40 ( 5 ): 205 - 211 .
Kogelmann K , Jarczak D , Scheller M , et al . Hemoadsorption by CytoSorb in septic patients:a case series [J ] . Crit Care , 2017 , 21 ( 1 ): 74 .
田兴国 , 陈 志 , 贺慧为 , 等 . 多黏菌素B血液灌流对脓毒症和脓毒症休克患者预后影响的荟萃分析 [J ] . 中国呼吸与危重监护杂志 , 2020 , 19 ( 1 ): 16 - 21 .
Tian XG , Chen Z , He HW , et al . The effect of polymyxin B hemoperfusion on prognosis of patients with sepsis and septic shock:a meta-analysis [J ] . Chin J Respir Crit Care Med , 2020 , 19 ( 1 ): 16 - 21 .
Dellinger RP , Bagshaw SM , Antonelli M , et al . Effect of targeted polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level:the EUPHRATES randomized clinical trial [J ] . JAMA , 2018 , 320 ( 14 ): 1455 - 1463 .
Livigni S , Bertolini G , Rossi C , et al . Efficacy of coupled plasma filtration adsorption(CPFA) in patients with septic shock:a multicenter randomised controlled clinical trial [J ] . BMJ Open , 2014 , 4 ( 1 ): 23 - 68 .
Poole D , D’Arrigo S . Coupled plasma filtration and adsorption for the treatment of septic shock [J ] . Intensive Care Med , 2022 , 48 ( 4 ): 493 - 495 .
Davenport A , Honore PM . Continuous renal replacement therapy under special conditions like sepsis,burn,cardiac failure,neurotrauma,and liver failure [J ] . Semin Dial , 2021 , 34 ( 6 ): 457 - 471 .
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