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重庆医科大学附属第一医院神经外科,重庆 400016
杨博成,Email:1462302629@qq.com, 研究方向:功能神经外科及脑肿瘤研究和治疗。
谢延风,Email:xyf3058@163.com。
收稿:2021-10-03,
纸质出版:2022-07-28
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杨博成,蒋理,谢延风.复发胶质母细胞瘤治疗进展[J].重庆医科大学学报,2022,47(7):857-861.
Yang Bocheng,Jiang Li,Xie Yanfeng.Progress in the treatment of recurrent glioblastoma[J].Journal of Chongqing Medical University,2022,47(7):857-861.
杨博成,蒋理,谢延风.复发胶质母细胞瘤治疗进展[J].重庆医科大学学报,2022,47(7):857-861. DOI: 10.13406/j.cnki.cyxb.003048.
Yang Bocheng,Jiang Li,Xie Yanfeng.Progress in the treatment of recurrent glioblastoma[J].Journal of Chongqing Medical University,2022,47(7):857-861. DOI: 10.13406/j.cnki.cyxb.003048.
胶质母细胞瘤即使经过最大限度的手术切除及规范放化疗,仍有极高的复发概率;因而针对日益增多的复发胶质母细胞瘤患者,如何达到有效治疗及改善预后一直是神经肿瘤学的巨大挑战。本文拟从多个方面综述现有的多种针对复发胶质母细胞瘤的治疗方式,并对未来可能治疗方向进行预测。
Glioblastoma still has a high probability of recurrence even after maximum surgical resection and standardized radiotherapy and chemotherapy. Therefore, for the increasing number of recurrent glioblastoma patients, how to achieve effective treatment and improve the prognosis of patients has always been a great challenge in neuro-oncology. This paper aims to review the existing treatment methods for recurrent glioblastoma from multiple aspects, and to predict the possible treatment directions in the future.
Stupp R , Wong ET , Kanner AA , et al . NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma:a randomised phase Ⅲ trial of a novel treatment modality [J ] . Eur J Cancer , 2012 , 48 ( 14 ): 2192 - 2202 .
Eckel-Passow JE , Lachance DH , Molinaro AM , et al . Glioma groups based on 1p/19q,IDH,and TERT promoter mutations in tumors [J ] . N Engl J Med , 2015 , 372 ( 26 ): 2499 - 2508 .
Louis DN , Perry A , Reifenberger G , et al . The 2016 World Health Organization classification of tumors of the central nervous system:a summary [J ] . Acta Neuropathol , 2016 , 131 ( 6 ): 803 - 820 .
Brzozowska A , Toruń A , Mazurkiewicz M . The impact of surgery on the efficacy of adjuvant therapy in glioblastoma multiforme [J ] . Adv Clin Exp Med , 2015 , 24 ( 2 ): 279 - 287 .
Ringel F , Pape H , Sabel M , et al . Clinical benefit from resection of recurrent glioblastomas:results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection [J ] . Neuro Oncol , 2016 , 18 ( 1 ): 96 - 104 .
Sastry RA , Shankar GM , Gerstner ER , et al . The impact of surgery on survival after progression of glioblastoma:a retrospective cohort analysis of a contemporary patient population [J ] . J Clin Neurosci , 2018 , 53 : 41 - 47 .
Lu VM , Jue TR , McDonald KL , et al . The survival effect of repeat surgery at glioblastoma recurrence and its trend:a systematic review and Meta-analysis [J ] . World Neurosurg , 2018 , 115 : 453 - 459 . e3.
Hou LC , Veeravagu A , Hsu AR , et al . Recurrent glioblastoma multiforme:a review of natural history and management options [J ] . Neurosurg Focus , 2006 , 20 ( 4 ): E5 .
Pala A , Schmitz AL , Knoll A , et al . Is MGMT promoter methylation to be considered in the decision making for recurrent surgery in glioblastoma patients? [J ] . Clin Neurol Neurosurg , 2018 , 167 : 6 - 10 .
Wallner KE , Galicich JH , Krol G , et al . Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma [J ] . Int J Radiat Oncol Biol Phys , 1989 , 16 ( 6 ): 1405 - 1409 .
Combs SE , Thilmann C , Edler L , et al . Efficacy of fractionated stereotactic reirradiation in recurrent gliomas:long-term results in 172 patients treated in a single institution [J ] . J Clin Oncol , 2005 , 23 ( 34 ): 8863 - 8869 .
Reynaud T , Bertaut A , Farah W , et al . Hypofractionated stereotactic radiotherapy as a salvage therapy for recurrent high-grade gliomas:single-center experience [J ] . Technol Cancer Res Treat , 2018 , 17 : 1533033818806498 .
Fogh SE , Andrews DW , Glass J , et al . Hypofractionated stereotactic radiation therapy:an effective therapy for recurrent high-grade gliomas [J ] . J Clin Oncol , 2010 , 28 ( 18 ): 3048 - 3053 .
Taunk NK , Moraes FY , Escorcia FE , et al . External beam re-irradiation,combination chemoradiotherapy,and particle therapy for the treatment of recurrent glioblastoma [J ] . Expert Rev Anticancer Ther , 2016 , 16 ( 3 ): 347 - 358 .
Cabrera AR , Kirkpatrick JP , Fiveash JB , et al . Radiation therapy for glioblastoma:executive summary of an American Society for Radiation oncology evidence-based clinical practice guideline [J ] . Pract Radiat Oncol , 2016 , 6 ( 4 ): 217 - 225 .
Kazmi F , Soon YY , Leong YH , et al . re-irradiation for recurrent glioblastoma(GBM):a systematic review and Meta-analysis [J ] . J Neurooncol , 2019 , 142 ( 1 ): 79 - 90 .
Stupp R , Mason WP , van den Bent MJ , et al . Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma [J ] . N Engl J Med , 2005 , 352 ( 10 ): 987 - 996 .
Kim SH , Yoo H , Chang JH , et al . Procarbazine and CCNU chemotherapy for recurrent glioblastoma with MGMT promoter methylation [J ] . J Korean Med Sci , 2018 , 33 ( 24 ): e167 .
Jungk C , Chatziaslanidou D , Ahmadi R , et al . Chemotherapy with BCNU in recurrent glioma:analysis of clinical outcome and side effects in chemotherapy-naïve patients [J ] . BMC Cancer , 2016 , 16 ( 1 ): 81 .
Weller M , Tabatabai G , Kästner B , et al . MGMT promoter methylation is a strong prognostic biomarker for benefit from dose-intensified temozolomide rechallenge in progressive glioblastoma:the DIRECTOR trial [J ] . Clin Cancer Res , 2015 , 21 ( 9 ): 2057 - 2064 .
Franceschi E , Lamberti G , Visani M , et al . Temozolomide rechallenge in recurrent glioblastoma:when is it useful? [J ] . Future Oncol , 2018 , 14 ( 11 ): 1063 - 1069 .
Wick W , Gorlia T , Bendszus M , et al . Lomustine and bevacizumab in progressive glioblastoma [J ] . N Engl J Med , 2017 , 377 ( 20 ): 1954 - 1963 .
Yang SB , Gao KD , Jiang T , et al . Bevacizumab combined with chemotherapy for glioblastoma:a Meta-analysis of randomized controlled trials [J ] . Oncotarget , 2017 , 8 ( 34 ): 57337 - 57344 .
Taal W , Oosterkamp HM , Walenkamp AM , et al . Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial):a randomised controlled phase 2 trial [J ] . Lancet Oncol , 2014 , 15 ( 9 ): 943 - 953 .
Kanner AA , Wong ET , Villano JL , et al . Post hoc analyses of intention-to-treat population in phase Ⅲ comparison of NovoTTF-100A™ system versus best physician's choice chemotherapy [J ] . Semin Oncol , 2014 , 41 : S25 - S34 .
Nabors LB , Portnow J , Ahluwalia M , et al . Central nervous system cancers,version 3.2020,NCCN clinical practice guidelines in oncology [J ] . J Natl Compr Canc Netw , 2020 , 18 ( 11 ): 1537 - 1570 .
Mrugala MM , Engelhard HH , Dinh Tran D , et al . Clinical practice experience with NovoTTF-100A™ system for glioblastoma:the patient registry dataset (PRiDe) [J ] . Semin Oncol , 2014 , 41 Suppl 6 : S4 - S13 .
Kirson ED , Giladi M , Gurvich Z , et al . Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs [J ] . Clin Exp Metastasis , 2009 , 26 ( 7 ): 633 - 640 .
Stupp R , Taillibert S , Kanner A , et al . Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma:a randomized clinical trial [J ] . JAMA , 2017 , 318 ( 23 ): 2306 - 2316 .
Kirson ED , Dbalý V , Tovarys F , et al . Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors [J ] . Proc Natl Acad Sci USA , 2007 , 104 ( 24 ): 10152 - 10157 .
Sampson JH , Maus MV , June CH . Immunotherapy for brain tumors [J ] . J Clin Oncol , 2017 , 35 ( 21 ): 2450 - 2456 .
Nduom EK , Wei J , Yaghi NK , et al . PD-L1 expression and prognostic impact in glioblastoma [J ] . Neuro Oncol , 2016 , 18 ( 2 ): 195 - 205 .
Reardon DA , Brandes AA , Omuro A , et al . Effect of nivolumab vs bevacizumab in patients with recurrent glioblastoma:the CheckMate 143 phase 3 randomized clinical trial [J ] . JAMA Oncol , 2020 , 6 ( 7 ): 1003 - 1010 .
Cloughesy TF , Mochizuki AY , Orpilla JR , et al . Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma [J ] . Nat Med , 2019 , 25 ( 3 ): 477 - 486 .
Schuster J , Lai RK , Recht LD , et al . A phase Ⅱ,multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma:the ACT Ⅲ study [J ] . Neuro Oncol , 2015 , 17 ( 6 ): 854 - 861 .
Reardon DA , Desjardins A , Vredenburgh JJ , et al . Rindopepimut with bevacizumab for patients with relapsed EGFRvIII-expressing glioblastoma (ReACT):results of a double-blind randomized phase Ⅱ trial [J ] . Clin Cancer Res , 2020 , 26 ( 7 ): 1586 - 1594 .
Foreman PM , Friedman GK , Cassady KA , et al . Oncolytic virotherapy for the treatment of malignant glioma [J ] . Neurotherapeutics , 2017 , 14 ( 2 ): 333 - 344 .
Desjardins A , Gromeier M , 2nd Herndon JE , et al . Recurrent glioblastoma treated with recombinant poliovirus [J ] . N Engl J Med , 2018 , 379 ( 2 ): 150 - 161 .
Lang FF , Conrad C , Gomez-Manzano C , et al . Phase I study of DNX-2401(Delta-24-RGD) oncolytic adenovirus:replication and immunotherapeutic effects in recurrent malignant glioma [J ] . J Clin Oncol , 2018 , 36 ( 14 ): 1419 - 1427 .
Wang SM , O'Rourke DM , Chawla S , et al . Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvⅢ chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma [J ] . Br J Cancer , 2019 , 120 ( 1 ): 54 - 56 .
李庆岗 , 刘 锐 , 张剑宁 . 贝伐珠单抗联合替莫唑胺胶囊治疗复发胶质母细胞瘤 [J ] . 转化医学杂志 , 2018 , 7 ( 3 ): 144 - 147 .
Li QG , Liu R , Zhang JN . Bevacizumab in combination with temozolomide capsules for treatment of recurrent glioblastoma [J ] . Transl Med J , 2018 , 7 ( 3 ): 144 - 147 .
颜成睿 . 贝伐单抗联合化疗治疗复发胶质母细胞瘤的相关回顾性研究 [D ] . 北京 : 北京协和医学院 , 2017 .
Yan CR . Retrospective study of bevacizumab combined with chemotherapy in the treatment of recurrent glioblastoma [D ] . Beijing : Peking Union Medical College , 2017 .
Cabrera AR , Cuneo KC , Desjardins A , et al . Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas:a prospective trial [J ] . Int J Radiat Oncol Biol Phys , 2013 , 86 ( 5 ): 873 - 879 .
Cuneo KC , Vredenburgh JJ , Sampson JH , et al . Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas [J ] . Int J Radiat Oncol Biol Phys , 2012 , 82 ( 5 ): 2018 - 2024 .
Candolfi M , Kroeger KM , Muhammad AK , et al . Gene therapy for brain cancer:combination therapies provide enhanced efficacy and safety [J ] . Curr Gene Ther , 2009 , 9 ( 5 ): 409 - 421 .
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