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1.辽宁省人民医院骨五科,辽宁 沈阳 110016
2.四川大学华西临床医学院康复医学科,四川 成都 610041
任伟剑,E-mail:d8501@lnph.com
收稿:2025-11-05,
网络首发:2026-07-24,
纸质出版:2026-07-25
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徐贯彭,刘莛予,刘军等.单侧双通道内镜腰椎融合术治疗单节段Ⅰ度腰椎滑脱症失血量的危险因素分析[J].局解手术学杂志,2026,35(07):569-573.
XU Guan-peng,LIU Ting-yu,LIU Jun,et al.Risk factors for blood loss in unilateral biportal endoscopic lumbar interbody fusion for single-segment grade Ⅰ lumbar spondylolisthesis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(07):569-573.
徐贯彭,刘莛予,刘军等.单侧双通道内镜腰椎融合术治疗单节段Ⅰ度腰椎滑脱症失血量的危险因素分析[J].局解手术学杂志,2026,35(07):569-573. DOI: 10.11659/jjssx.11E025120.
XU Guan-peng,LIU Ting-yu,LIU Jun,et al.Risk factors for blood loss in unilateral biportal endoscopic lumbar interbody fusion for single-segment grade Ⅰ lumbar spondylolisthesis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(07):569-573. DOI: 10.11659/jjssx.11E025120.
目的
2
探讨单侧双通道内镜腰椎融合术(UBE-LIF)治疗单节段Ⅰ度腰椎滑脱症患者的失血情况,并分析影响失血量的相关危险因素。
方法
2
回顾性分析2023年4月至2024年10月辽宁省人民医院收治的52例单节段Ⅰ度腰椎滑脱症患者的临床资料。收集患者的一般资料[年龄、性别、体质量指数(BMI)、高血压及糖尿病等
]
、手术资料(病变节段、手术时间)以及相关检验指标[骨密度、血红蛋白(Hb)、红细胞压积(HCT)、血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)
]
。应用Gross公式计算总失血量。进行单因素分析和
Pearson
相关性分析初步筛选与失血量相关的因素,应用多因素线性回归模型确定失血量的独立危险因素,并构建受试者工作特征(
ROC
)曲线评估各危险因素对失血量的预测效能。
结果
2
患者平均手术时间为(270.58±59.61)min,总失血量为(308.15±121.36)mL。术后Hb为(113.63±12.23)g/L,低于术前的(127.48±12.08)g/L(
P
<
0.05);术后HCT为(34.42±4.41)%,低于术前的(38.61±4.91)%(
P
<
0.05)。单因素分析显示,性别、高血压、糖尿病和病变节段与失血量无显著相关性(
P
>
0.05)。
Pearson
相关性分析显示,手术时间(
r
=0.562,
P
=0.032)、骨密度(
r
=-0.412,
P
=0.021)、PLT(
r
=-0.421,
P
=0.018)和APTT(
r
=-0.392,
P
=0.029)与失血量显著相关;年龄(
r
=0.306,
P
=0.095)、BMI(
r
=0.274,
P
=0.136)、PT(
r
=-0.014,
P
=0.983)、FIB(
r
=0.184,
P
=0.323)与失血量无显著相关性。
ROC
曲线分析结果显示,手术时间、骨密度、PLT预测术后大量失血的曲线下面积(
AUC
)分别为0.813(95%
CI
:0.688~0.938,
P
<
0.001)、0.794(95%
CI
:0.654~0.934,
P
<
0.001)、0.802(95%
CI
:0.683~0.921,
P
<
0.001),对术后大量失血均具有良好的预测价值。多因素线性回归分析显示,手术时间延长、骨密度和PLT降低是影响失血量的独立危险因素(
P
<
0.05)。
结论
2
UBE-LIF治疗单节段Ⅰ度腰椎滑脱症会导致一定程度的失血,其中手术时间延长、骨密度和PLT降低是影响术后大量失血的独立危险因素。临床实践中针对具有这些特征的患者应加强管理,以提高手术安全性。
Objective
2
To investigate blood loss in patients with single-segment grade Ⅰ lumbar spondylolisthesis treated with unilateral biportal endoscopic lumbar interbody fusion (UBE-LIF) and to analyze the risk factors associated with blood loss.
Methods
2
A retrospective analysis was conducted on the clinical data of 52 patients with single-segment grade Ⅰ lumbar spondylolisthesis admitted to People's Hospital of Liaoning Province from April 2023 to October 2024. The general information [age,gender,body mass index (BMI)],hypertension and diabetes),surgical details (involved segment,operative time),and related laboratory indicators [bone mineral density,hemoglobin (Hb),hematocrit (HCT),platelet count (PLT),prothrombin time (PT),activated partial thromboplastin time (APTT),and fibrinogen (FIB)]. Total blood loss was calculated using the Gross formula. Univariate analysis and
Pearson
correlation analysis were conducted to preliminarily screen factors related to blood loss. Multiple linear regression model was performed to identify independent risk factors for blood loss,and
receiver operating characteristic
(
ROC
) curve was constructed to evaluate the predictive performance of each risk fa
ctor for blood loss.
Results
2
The mean operative time was (270.58±59.61)minutes,and the total blood loss was (308.15±121.36)mL. Postoperative Hb was (113.63±12.23)g/L,which was lower than the preoperative value of (127.48±12.08)g/L (
P
<
0.05). Postoperative HCT was (34.42±4.41)%,which was lower than the preoperative value of (38.61±4.91)% (
P
<
0.05). Univariate analysis showed that no significant correlations were found between blood loss and gender,hypertension,diabetes,or affected segment (
P
>
0.05).
Pearson
correlation analysis revealed that operative time (
r
=0.562,
P
=0.032),bone mineral density (
r
=-0.412,
P
=0.021),PLT (
r
=-0.421,
P
=0.018),and APTT (
r
=-0.392,
P
=0.029) were significantly correlated with blood loss,while age (
r
=0.306,
P
=0.095),BMI (
r
=0.274,
P
=0.136),PT (
r
=-0.014,
P
=0.983),and FIB (
r
=0.184,
P
=0.323) showed no significant correlations with blood loss.
ROC
curve analysis showed that the
area under the curve
(
AUC
) for predicting severe blood loss was 0.813 (95%
CI
: 0.688 to 0.938,
P
<
0.001) for operative time,0.794 (95%
CI
: 0.654 to 0.934,
P
<
0.001) for bone mineral density,and 0.802(95%
CI
:0.683 to 0.921,
P
<
0.001) for PLT,indicating good predictive value for severe blood loss. Multiple linear regression analysis showed that prolonged operative time,and decreased bone mineral density and PLT were independent risk factors for blood loss (
P
<
0.05).
Conclusion
2
UBE-LIF for single‑segment grade Ⅰ lumbar spondylolisthesis results in a certain degree of blood loss. The prolonged operative time,decreased bone mineral density and reduced PLT are independent risk factors for increased postoperative blood loss. In clinical practice,more intensive management should be considered for patients presenting with these features to enhance surgical safety.
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