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1.深圳市龙华区人民医院麻醉科,广东 深圳 518100
2.大连市中心医院麻醉科,辽宁 大连 116000
收稿:2025-11-11,
纸质出版:2026-06-25
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董俊锋,蔡秋萍,刘伟等.驱动压导向个体化PEEP对俯卧位全麻脊柱手术患者肺功能的影响[J].局解手术学杂志,2026,35(06):478-482.
DONG Jun-feng,CAI Qiu-ping,LIU Wei,et al.Effects of driving pressure-guided individualized PEEP on pulmonary function in patients undergoing spinal surgery under general anesthesia in the prone position[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(06):478-482.
董俊锋,蔡秋萍,刘伟等.驱动压导向个体化PEEP对俯卧位全麻脊柱手术患者肺功能的影响[J].局解手术学杂志,2026,35(06):478-482. DOI: 10.11659/jjssx.11E025059.
DONG Jun-feng,CAI Qiu-ping,LIU Wei,et al.Effects of driving pressure-guided individualized PEEP on pulmonary function in patients undergoing spinal surgery under general anesthesia in the prone position[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(06):478-482. DOI: 10.11659/jjssx.11E025059.
目的
2
探究驱动压(DP)导向的个体化呼气末正压(PEEP)对俯卧位全麻脊柱手术患者肺功能与氧合指数的影响。
方法
2
选择2020年10月至2021年10月大连市中心医院收治的95例行择期俯卧位全麻脊柱手术的患者,随机分为固定组(
n
=47)和个体化组(
n
=48)。固定组患者设定PEEP为5 cmH
2
O,潮气量(VT)为6 mL/kg,无肺复张手法;个体化组患者采用DP导向的个体化PEEP,VT同固定组,无肺复张手法。比较2组患者的手术指标,入室吸氧前(T0)、机械通气后30 min(T1)、机械通气后1 h(T2)、机械通气后2 h(T3)及入麻醉复苏室后30 min(T4)的氧合指数[动脉血氧分压(PaO
2
)/吸入氧浓度(FiO
2
)
]
。比较2组患者T1、T2、T3的肺功能[气道峰压(Ppeak)、气道平均压(Pmean)、肺顺应性(Cldyn)
]
,T0、术后1 d(T5)、术后3 d(T6)的炎症因子指标[中性粒细胞计数(NEUT)、白细胞计数(WBC)、C反应蛋白(CRP)
]
及术后30 d的肺部并发症发生率。
结果
2
2组患者手术指标与肺部并发症发生率比较,差异均无统计学意义(
P
>
0.05)。个体化组患者T2、T3、T4的PaO
2
/FiO
2
均高于固定组(
P
<
0.05)。个体化组患者T1、T2、T3的Cldyn均大于固定组(
P
<
0.05),Ppeak、Pmean均小于固定组(
P
<
0.05)。个体化组患者T5的WBC低于固定组(
P
<
0.05),T5、T6的CRP低于固定组(
P
<
0.05)。
结论
2
DP导向的个体化PEEP可有效改善俯卧位全麻脊柱手术患者的氧合状态与肺功能,同时有助于减轻术后炎症反应,且不增加手术相关风险及肺部并发症发生率,可为患者提供更为有效的优化策略。
Objective
2
To investigate the effects of driving pressure (DP)-guided individualized positive end-expiratory pressure (PEEP) on pulmonary function and oxygenation index in patients undergoing spinal surgery under general anesthesia in the prone position.
Methods
2
A total of 95 patients who underwent elective spinal surgery under general anesthesia in the prone position at Dalian Central Hospital from October 2020 to October 2021 were randomly divided into the fixed group (
n
=47) and the individualized group (
n
=48). Patients in the fixed group received a PEEP of 5 cmH₂O and a tidal volume (VT) of 6 mL/kg, without lung recruitment maneuvers. Patients in the individualized group received DP-guided individualized PEEP with the same VT as the fixed group and also without lung recruitment maneuvers. The surgical indicators and the oxygenation index [arterial partial pressure of oxygen(PaO
2
)/fraction of inspired oxygen(FiO
2
)] before oxygen inhalation upon operating room entry (T0), 30 minutes after mechanical ventilation (T1), 1 hour after mechanical ventilation (T2), 2 hours after mechanical ventilation (T3), and 30 minutes after admission to the post-anesthesia care unit (T4) were compared between the two groups. The pulmonary function [peak airway pressure (Ppeak), mean airway pressure (Pmean), dynamic lung compliance (Cldyn)] at T1, T2, and T3, the inflammatory factors [neutrophil count (NEUT), white blood cell count (WBC), C-reactive protein (CRP)] at T0, 1 day postoperatively (T5) and 3 days postoperatively (T6), and the incidence of pulmonary complications at 30 days postoperatively were compared between the two groups.
Results
2
There was no statistically significant difference in the surgical indicators or the incidence of pulmonary complications betwe
en the two groups (
P
>
0.05). The individualized group had higher PaO
2
/FiO
2
ratios at T2, T3, and T4, greater Cldyn at T1, T2, and T3, and lower Ppeak and Pmean than the fixed group (
P
<
0.05). The individualized group had lower WBC at T5, and lower CRP at T5, T6 than the fixed group (
P
<
0.05).
Conclusion
2
DP-guided individualized PEEP can effectively improve the oxygenation status and pulmonary function in patients undergoing spinal surgery under general anesthesia in the prone position. It may also help alleviate postoperative inflammatory reactions without increasing surgical-related risks or the incidence of pulmonary complications, thereby providing more effective optimization strategies for patients.
刘瑞红 , 任震晴 , 崔丽丽 , 等 . 全麻患者术中俯卧位管理的循证实践 [J]. 护理学杂志 , 2023 , 38 ( 6 ): 50 - 54 . doi: 10.3870/j.issn.1001-4152.2023.06.050 http://dx.doi.org/10.3870/j.issn.1001-4152.2023.06.050 .
王亮 , 孙仁波 , 胡许平 , 等 . 驱动压导向呼气末正压个体化滴定对老年患者腹腔镜结直肠癌根治术后肺不张的影响 [J]. 临床麻醉学杂志 , 2023 , 39 ( 4 ): 357 - 362 . doi: 10.12089/jca.2023.04.004 http://dx.doi.org/10.12089/jca.2023.04.004 .
张建友 , 郭宁 , 杨大威 , 等 . 压力控制容量保证通气对胸腔镜肺叶切除术患者围术期肺功能的影响 [J]. 临床麻醉学杂志 , 2024 , 40 ( 8 ): 820 - 824 . doi: 10.12089/jca.2024.08.007 http://dx.doi.org/10.12089/jca.2024.08.007 .
刘世建 , 卢彬 , 江倩 , 等 . 两种胸腔镜肺叶切除术个体化呼气末正压通气方法的比较 [J]. 腹腔镜外科杂志 , 2024 , 29 ( 9 ): 652 - 656 . doi: 10.13499/j.cnki.fqjwkzz.2024.09.652 http://dx.doi.org/10.13499/j.cnki.fqjwkzz.2024.09.652 .
李如意 , 孙艳 , 嵇富海 . 不同潮气量复合基于EIT的个体化PEEP对妇科腹腔镜手术患者肺通气分布的影响 [J]. 国际麻醉学与复苏杂志 , 2025 , 46 ( 4 ): 366 - 371 . doi: 10.3760/cma.j.cn321761-2024 1214-01242 http://dx.doi.org/10.3760/cma.j.cn321761-20241214-01242 .
Zhang C , Xu F , Li W , et al . Driving pressure-guided individualized positive end-expiratory pressure in abdominal surgery:a randomized controlled trial [J]. Anesth Analg , 2021 , 133 ( 5 ): 1197 - 1205 . doi: 10.1213/ANE.0000000000005575 http://dx.doi.org/10.1213/ANE.0000000000005575 .
尚英 , 刘蒙 , 周萌 , 等 . 围手术期个体化呼气末正压通气的研究进展 [J]. 国际麻醉学与复苏杂志 , 2023 , 44 ( 1 ): 94 - 99 . doi: 10.3760/cma.j.cn321761-20220408-00721 http://dx.doi.org/10.3760/cma.j.cn321761-20220408-00721 .
石进涛 , 朱娟 , 邓鉴 , 等 . 肺动态顺应性指导个体化呼气末正压通气对老年患者腹腔镜结直肠癌术中肺功能的影响 [J]. 临床麻醉学杂志 , 2024 , 40 ( 1 ): 36 - 41 . doi: 10.12089/jca.2024.01.007 http://dx.doi.org/10.12089/jca.2024.01.007 .
Park M , Ahn HJ , Kim JA , et al . Driving pressure during thoracic surgery:a randomized clinical trial [J]. Anesthesiology , 2019 , 130 ( 3 ): 385 - 393 . doi: 10.1097/ALN.0000000000002600 http://dx.doi.org/10.1097/ALN.0000000000002600 .
李长松 , 于大朋 , 钱涛 , 等 . 个体化肺保护通气对老年患者围术期肺功能的影响 [J]. 临床麻醉学杂志 , 2024 , 40 ( 12 ): 1252 - 1258 . doi: 10.12089/jca.2024.12.004 http://dx.doi.org/10.12089/jca.2024.12.004 .
Pan X , Wang D . Effect of different positive end-expiratory pressure levels in patients undergoing laparoscopic cholecystectomy under general anesthesia [J]. Pak J Med Sci , 2025 , 41 ( 3 ): 719 - 723 . doi: 10.12669/pjms.41.3.11348 http://dx.doi.org/10.12669/pjms.41.3.11348 .
李金路 , 吴雪梅 , 谢红 , 等 . 全麻患者肺保护性通气时个体化PEEP的确定:EIT法和Cdyn法比较 [J]. 中华麻醉学杂志 , 2021 , 41 ( 1 ): 72 - 75 . doi: 10.3760/cma.j.cn131073.20200310.00119 http://dx.doi.org/10.3760/cma.j.cn131073.20200310.00119 .
刘思淇 , 金立民 , 宋雪松 . 高水平呼气末正压通气联合肺复张在肥胖患者全麻俯卧位手术中的应用研究 [J]. 中国实验诊断学 , 2024 , 28 ( 4 ): 411 - 416 . doi: 10.3969/j.issn.1007-4287.2024. 04.006 http://dx.doi.org/10.3969/j.issn.1007-4287.2024.04.006 .
张美琪 , 张艾迪 , 于铁莉 . 格隆溴铵对全麻下俯卧位脊柱手术患者肺功能影响的研究进展 [J]. 亚洲临床医学杂志 , 2023 , 6 ( 11 ): 10 - 12 . doi: 10.12345/yzlcyxzz.v6i11.14520 http://dx.doi.org/10.12345/yzlcyxzz.v6i11.14520 .
闭玉华 , 黄俊萍 . 以驱动压为导向个体化滴定式呼气末正压通气在老年腹腔镜结肠癌患者中的应用效果 [J]. 重庆医学 , 2023 , 52 ( 3 ): 348 - 352 . doi: 10.3969/j.issn.1671-8348.2023.03.006 http://dx.doi.org/10.3969/j.issn.1671-8348.2023.03.006 .
Fogagnolo A , Montanaro F , Al-Husinat L , et al . Management of intraoperative mechanical ventilation to prevent postoperative complications after general anesthesia:a narrative review [J]. J Clin Med , 2021 , 10 ( 12 ): 2656 . doi: 10.3390/jcm10122656 http://dx.doi.org/10.3390/jcm10122656 .
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