
浏览全部资源
扫码关注微信
江苏省人民医院宿迁医院麻醉与围术期医学科,江苏 宿迁 223800
许旭,E-mail:luxuan0102005@163.com
收稿:2025-08-03,
纸质出版:2026-05-25
移动端阅览
陆璇,许旭,徐幻浠等.不同CO2气腹压力对肥胖患者腹腔镜下减重手术效果的影响[J].局解手术学杂志,2026,35(05):441-444. DOI: 10.11659/jjssx.08E025003.
LU Xuan,XU Xu,XU Huan-xi,et al.Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):441-444.
陆璇,许旭,徐幻浠等.不同CO2气腹压力对肥胖患者腹腔镜下减重手术效果的影响[J].局解手术学杂志,2026,35(05):441-444. DOI: 10.11659/jjssx.08E025003. DOI:
LU Xuan,XU Xu,XU Huan-xi,et al.Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):441-444. DOI: 10.11659/jjssx.08E025003.
目的
2
评价不同CO
2
气腹压力对肥胖患者腹腔镜下减重手术急性肺损伤、苏醒质量及疼痛的影响。
方法
2
选取我院行腹腔镜下袖状胃切除减重手术的肥胖患者70例为研究对象,随机分为高压组和低压组,每组35例,术中CO
2
气腹压力分别维持在16 mmHg和12 mmHg。对2组患者的手术情况、呼吸力学指标、炎症因子水平、全身麻醉苏醒情况及疼痛情况进行比较。
结果
2
2组患者的手术时间、术中出血量、术中丙泊酚用量、术中瑞芬太尼用量及术中罗库溴铵用量比较,差异均无统计学意义(
P
0.05)。在手术60 min,低压组患者的气道峰压(Ppeak)及气道平台压(Pplat)均显著低于高压组(
P
0.05)。低压组患者在机械通气结束即刻的肿瘤坏死因子α(TNF-α)及白细胞介素-6(IL-6)水平均显著低于高压组(
P
0.05)。低压组患者的自主呼吸恢复时间、苏醒时间、气管拔管时间及麻醉苏醒室停留时间均显著短于高压组(
P
0.05)。在术后12 h和24 h,低压组患者的疼痛评分均显著低于高压组(
P
0.05)。低压组患者术后48 h内补救镇痛舒芬太尼用量显著少于高压组(
P
0.05)。
结论
2
对于行腹腔镜下减重手术的肥胖患者,与16 mmHg的CO
2
气腹压力相比,12 mmHg的CO
2
气腹压力不增加手术难度及麻醉药物用量,患者苏醒质量更好,急性肺损伤及术后疼痛更轻。
Objective
2
To evaluate the effects of different CO₂ pneumoperitoneum pressures on acute lung injury,recovery quality,and pain in obese patients undergoing laparoscopic bariatric surgery.
Methods
2
A total of 70 obese patients who underwent laparoscopic sleeve gastrectomy bariatric surgery at our hospital were selected as the study subjects and randomly divided into the high-pressure group (
n
=35) and the low-pressure group (
n
=35), with intraoperative CO₂ pneumoperitoneum pressure at 16 mmHg and 12 mmHg, respectively.The surgical conditions, respiratory mechanics indicators, inflammatory factor levels, general anesthesia recovery status, and pain status were compared between the two groups.
Results
2
There were no statistically significant differences between the two groups in terms of operation time, intraoperative blood loss, intraoperative dosage of propofol, intraoperative dosage of remifentanil, and intraoperative dosage of rocuronium bromide (
P
0.05).At 60 minutes of operation, the peak airway pressure (Ppeak) and plateau airway pressure (Pplat) of patients in the low-pressure group were significantly lower than those in the high-pressure group (
P
0.05). Immediately after mechanical ventilation, the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) of patients in the low-pressure group were significantly lower than those in the high-pressure group (
P
0.05).The time to spontaneous breathing recovery, awakening time, tracheal extubation time, and length of stay in the post-anesthesia care unit of patients in the low-pressure group were significantly shorter than those in the high-pressure group (
P
0.05).At 12 and 24 hours after surgery, pain scores of patients in the low-pressure group were significantly lower than those in the high-pressure group (
P
0.05).The dosage of sufentanil for rescue analgesia within 48 hours after surgery of patients in the low-pressure group was significantly less than that in the high-pressure gro
up (
P
0.05).
Conclusion
2
For obese patients undergoing laparoscopic bariatric surgery, compared with a CO₂ pneumoperitoneum pressure of 16 mmHg, 12 mmHg CO₂ pneumoperitoneum pressure does not increase the difficulty of surgery or the dosage of anesthetic drugs, resulting in better recovery quality, milder acute lung injury, and less postoperative pain.
Li ZZ , Zhang B , Wang N , et al . A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota [J]. Gut , 2023 , 72 ( 4 ): 686 - 698 . doi: 10.1136/gutjnl-2022-328035 http://dx.doi.org/10.1136/gutjnl-2022-328035 .
Pan XF , Wang L , Pan A . Epidemiology and determinants of obesity in China [J]. Lancet Diabetes Endocrinol , 2021 , 9 ( 6 ): 373 - 392 . doi: 10.1016/S2213-8587(21)00045-0 http://dx.doi.org/10.1016/S2213-8587(21)00045-0 .
许艳 , 窦翊愷 , 王敏 , 等 . 肥胖患者情绪异常与减重手术效果的相关性 [J]. 四川精神卫生 , 2024 , 37 ( 1 ): 46 - 51 . doi: 10.11886/scjsws20231220002 http://dx.doi.org/10.11886/scjsws20231220002 .
Perdomo CM , Cohen RV , Sumithran P , et al . Contemporary medical,device,and surgical therapies for obesity in adults [J]. Lancet , 2023 , 401 ( 10382 ): 1116 - 1130 . doi: 10.1016/S0140-6736(22)02403-5 http://dx.doi.org/10.1016/S0140-6736(22)02403-5 .
邢颖 , 闫文貌 , 白日星 . 腹腔镜下胃袖状切除术在超级肥胖患者中减重效果及安全性分析 [J]. 中国普通外科杂志 , 2022 , 31 ( 10 ): 1307 - 1315 . doi: 10.7659/j.issn.1005-6947.2022.10.006 http://dx.doi.org/10.7659/j.issn.1005-6947.2022.10.006 .
Han YK , Jia Y , Wang HL , et al . Comparative analysis of weight loss and resolution of comorbidities between laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass:a systematic review and meta-analysis based on 18 studies [J]. Int J Surg , 2020 , 76 : 101 - 110 . doi: 10.1016/j.ijsu.2020.02.035 http://dx.doi.org/10.1016/j.ijsu.2020.02.035 .
Angrisani L , Santonicola A , Iovino P , et al . Bariatric surgery and endoluminal procedures:IFSO worldwide survey 2014 [J]. Obes Surg , 2017 , 27 ( 9 ): 2279 - 2289 . doi: 10.1007/s11695-017-x http://dx.doi.org/10.1007/s11695-017-x .
李玲霞 , 高东梅 , 胡彬 , 等 . 不同CO 2 气腹压力对老年腹腔镜结直肠癌根治术患者苏醒质量、应激反应和术后认知功能的影响 [J]. 现代生物医学进展 , 2022 , 22 ( 1 ): 177 - 181 . doi: 10.13241/j.cnki.pmb.2022.01.034 http://dx.doi.org/10.13241/j.cnki.pmb.2022.01.034 .
王浩 , 顾克 , 饶丽华 , 等 . 不同CO 2 气腹压力对超重或肥胖患者Trendelenburg体位腹腔镜全子宫切除术的影响 [J]. 局解手术学杂志 , 2025 , 34 ( 2 ): 150 - 153 . doi: 10.11659/jjssx.04E024121 http://dx.doi.org/10.11659/jjssx.04E024121 .
唐寅 , 魏珂 . 急性肺损伤的“肥胖悖论”研究进展 [J]. 国际麻醉学与复苏杂志 , 2022 , 43 ( 3 ): 307 - 311 . doi: 10.3760/cma.j.cn321761-20201115-00508 http://dx.doi.org/10.3760/cma.j.cn321761-20201115-00508 .
王亚茹 , 张蕾 . 肺保护策略在肥胖患者腹腔镜手术中应用的研究进展 [J]. 中国微创外科杂志 , 2024 , 24 ( 12 ): 828 - 833 . doi: 10.3969/j.issn.1009-6604.2024.12.009 http://dx.doi.org/10.3969/j.issn.1009-6604.2024.12.009 .
王太行 , 李慧娴 , 李宝利 , 等 . 肥胖对腹腔镜结直肠癌根治术后肺部并发症的影响 [J]. 中华医学杂志 , 2024 , 104 ( 18 ): 1610 - 1616 . doi: 10.3760/cma.j.cn112137-20230810-00191 http://dx.doi.org/10.3760/cma.j.cn112137-20230810-00191 .
张靖悦 , 郑惠文 , 党静静 , 等 . 艾司氯胺酮对腹腔镜减重手术患者苏醒质量及术后疼痛的影响 [J]. 国际麻醉学与复苏杂志 , 2023 , 44 ( 8 ): 821 - 826 . doi: 10.3760/cma.j.cn321761-20221123-00857 http://dx.doi.org/10.3760/cma.j.cn321761-20221123-00857 .
Nightingale CE , Margarson MP , Shearer E , et al . Peri-operative management of the obese surgical patient 2015: Association of Anaesthetists of Great Britain and Ireland Society for Obesity and Bariatric Anaesthesia [J]. Anaesthesia , 2015 , 70 ( 7 ): 859 - 876 . doi: 10.1111/anae.13101 http://dx.doi.org/10.1111/anae.13101 .
叶永青 , 周志坚 , 叶敏 . 不同二氧化碳气腹压力对腹腔镜阑尾切除术后疼痛发生率及程度的影响 [J]. 中国当代医药 , 2021 , 28 ( 4 ): 89 - 91 . doi: 10.13479/j.cnki.jip.2025.02.062 http://dx.doi.org/10.13479/j.cnki.jip.2025.02.062 .
刘勇 , 仲明杰 , 陈悦 , 等 . 不同CO 2 气腹压力对老年腹腔镜直肠癌根治术后谵妄及认知功能的影响 [J]. 局解手术学杂志 , 2024 , 33 ( 10 ): 867 - 870 . doi: 10.11659/jjssx.08E023117 http://dx.doi.org/10.11659/jjssx.08E023117 .
孙亚林 , 孙莉 , 李廷坤 , 等 . 不同气管插管术在胸腹腔镜食管癌根治术中的应用 [J]. 中华医学杂志 , 2021 , 101 ( 9 ): 630 - 635 . doi: 10.3760/cma.j.cn112137-20200628-01963 http://dx.doi.org/10.3760/cma.j.cn112137-20200628-01963 .
蒋梦桃 , 严丽洁 , 孙珊 . 不同气腹压力对腹腔镜全子宫切除术患者术中低体温、应激反应和术后恢复的影响 [J]. 川北医学院学报 , 2025 , 40 ( 6 ): 813 - 816 . doi: 10.3969/j.issn.1005-3697.2025.06.030 http://dx.doi.org/10.3969/j.issn.1005-3697.2025.06.030 .
0
浏览量
9
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621