
浏览全部资源
扫码关注微信
重庆医科大学附属第一医院泌尿外科,重庆 400016
梁思敏,E-mail:102017914@qq.com
收稿日期:2024-03-25,
纸质出版日期:2025-04-25
移动端阅览
吴凯军,陈代晖,李茂等.肾移植受者合并新型冠状病毒感染的诊疗进展[J].局解手术学杂志,2025,34(04):354-357.
WU Kai-jun,CHEN Dai-hui,LI Mao,et al.Progress in diagnosis and treatment of SARS-CoV-2 infection in kidney transplant recipients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(04):354-357.
吴凯军,陈代晖,李茂等.肾移植受者合并新型冠状病毒感染的诊疗进展[J].局解手术学杂志,2025,34(04):354-357. DOI: 10.11659/jjssx.03E024125.
WU Kai-jun,CHEN Dai-hui,LI Mao,et al.Progress in diagnosis and treatment of SARS-CoV-2 infection in kidney transplant recipients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(04):354-357. DOI: 10.11659/jjssx.03E024125.
自2019年12月新型冠状病毒肺炎(COVID-19)疫情爆发以来,不断发生变异的新型冠状病毒(SARS-CoV-2)给实体器官移植领域带来了前所未有的挑战。而肾移植受者(KTRs)由于常年服用免疫抑制剂及合并多种合并症,是SARS-CoV-2感染后进展为重症的高危人群。本文旨在结合当前新的流行病学背景,对肾移植工作的最新诊疗进展进行综述,为后续新的流行病学背景下KTRs的管理提供参考。
Since the outbreak of novel coronavirus pneumonia (COVID-19) in December 2019, SARS-CoV-2, which is constantly mutating, has brought unprecedented challenges to the field of solid organ transplantation. However, kidney transplant recipients (KTRs) are at high risk of developing severe disease after SARS-CoV-2 infection due to years of immunosuppressants and a variety of complications. This article aims to review the latest diagnosis and treatment progress of kidney transplantation under the current new epidemiological background, so as to provide reference for the subsequent management of KTRs under the new epidemiological background.
Yao H , Song Y , Chen Y , et al . Molecular architecture of the SARS-CoV-2 virus [J]. Cell , 2020 , 183 ( 3 ): 730 - 738.e13 . doi: 10.1016/j.cell.2020.09.018 http://dx.doi.org/10.1016/j.cell.2020.09.018 .
Ke Z , Oton J , Qu K , et al . Structures and distributions of SARS-CoV-2 spike proteins on intact virions:7838 [J]. Nature , 2020 , 588 ( 7838 ): 498 - 502 . doi: 10.1038/s41586-020-2665-2 http://dx.doi.org/10.1038/s41586-020-2665-2 .
Yang S , Yu Y , Xu Y , et al . Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure [J]. Lancet Infect Dis , 2024 , 24 ( 2 ): e70 - e72 . doi: 10.1016/S1473-3099(23)00744-2 http://dx.doi.org/10.1016/S1473-3099(23)00744-2 .
Rubin R . As COVID-19 cases surge,here's what to know about JN.1,the latest SARS-CoV-2 "variant of interest" [J]. JAMA , 2024 , 331 ( 5 ): 382 - 383 . doi: 10.1001/jama.2023.27841 http://dx.doi.org/10.1001/jama.2023.27841 .
Kates OS , Haydel BM , Florman SS , et al . Coronavirus disease 2019 in solid organ transplant:a multicenter cohort study [J]. Clin Infect Dis , 2021 , 73 ( 11 ): e4090 - e4099 . doi: 10.1093/cid/ciaa1097 http://dx.doi.org/10.1093/cid/ciaa1097 .
Bertrand D , Laurent C , Lemée V , et al . Efficacy of anti-SARS-CoV-2 monoclonal antibody prophylaxis and vaccination on the omicron variant of COVID-19 in kidney transplant recipients [J]. Kidney Int , 2022 , 102 ( 2 ): 440 - 442 . doi: 10.1016/j.kint.2022.05.007 http://dx.doi.org/10.1016/j.kint.2022.05.007 .
Raja MA , Mendoza MA , Villavicencio A , et al . COVID-19 in solid organ transplant recipients:a systematic review and meta-analysis of current literature [J]. Transplantation Rev (Orlando) , 2021 , 35 ( 1 ): 100588 . doi: 10.1016/j.trre.2020.100588 http://dx.doi.org/10.1016/j.trre.2020.100588 .
卫芬 , 李宁 , 王明君 , 等 . 肾移植受者新型冠状病毒肺炎的流行病学特征:单中心回顾性研究 [J]. 器官移植 , 2023 , 14 ( 5 ): 700 - 707 . doi: 10.3969/j.issn.1674-7445.2023098 http://dx.doi.org/10.3969/j.issn.1674-7445.2023098 .
Soriano JB , Murthy S , Marshall JC , et al . A clinical case definition of post-COVID-19 condition by a delphi consensus [J]. Lancet Infect Dis , 2022 , 22 ( 4 ): e102 - e107 . doi: 10.1016/S1473-3099(21)00703-9 http://dx.doi.org/10.1016/S1473-3099(21)00703-9 .
Global Burden of Disease Long COVID Collaborators , Wulf Hanson S , Abbafati C , et al . Estimated global proportions of individuals with persistent fatigue,cognitive,and respiratory symptom clusters following symptomatic COVID-19 in 2020 and 2021 [J]. JAMA , 2022 , 328 ( 16 ): 1604 - 1615 . doi: 10.1001/jama.2022.18931 http://dx.doi.org/10.1001/jama.2022.18931 .
Amorim CEN , Gomes VLT , Cristelli MP , et al . High prevalence of long-COVID among kidney transplant recipients:a longitudinal cohort study [J]. Transplantation , 2022 , 106 ( 12 ): 2408 - 2415 . doi: 10.1097/TP.0000000000004359 http://dx.doi.org/10.1097/TP.0000000000004359 .
Antonelli M , Penfold RS , Canas LDS , et al . SARS-CoV-2 infection following booster vaccination:illness and symptom profile in a prospective,observational community-based case-control study [J]. J Infect , 2023 , 87 ( 6 ): 506 - 515 . doi: 10.1016/j.jinf.2023.08.009 http://dx.doi.org/10.1016/j.jinf.2023.08.009 .
Amorim CEN , Cazetta GS , Cristelli MP , et al . Long COVID among kidney transplant recipients appears to be attenuated during the omicron predominance [J]. Transplantation , 2024 , 108 ( 4 ): 963 - 969 . doi: 10.1097/TP.0000000000004858 http://dx.doi.org/10.1097/TP.0000000000004858 .
Berto CG , Kotton CN . The other pandemic from the pandemic:a higher frequency of long COVID after omicron in kidney transplant recipients [J]. Transplantation , 2024 , 108 ( 4 ): 841 - 842 . doi: 10.1097/TP.0000000000004859 http://dx.doi.org/10.1097/TP.0000000000004859 .
中华医学会呼吸病学分会 , 中国医师协会呼吸医师分会 . 中国成人2019冠状病毒病的诊治与防控指南 [J]. 中华医学杂志 , 2021 , 101 ( 18 ): 1293 - 1356 . doi: 10.3760/cma.j.cn112137-20210112-00090 http://dx.doi.org/10.3760/cma.j.cn112137-20210112-00090 .
Suresh L . Six-month longitudinal antibody kinetics of mRNA COVID-19 vaccines [J]. Rheumatol Autoimmun , 2021 , 1 ( 1 ): 52 - 53 . doi: 10.1002/rai2.12005 http://dx.doi.org/10.1002/rai2.12005 .
Hod T , Ben-David A , Mor E , et al . Humoral response to the fourth bnt162b2 vaccination and link between the fourth dose,omicron infection,and disease severity in renal transplant recipients [J]. Transplantation , 2023 , 107 ( 1 ): 192 - 203 . doi: 10.1097/TP.000000 0000004383 http://dx.doi.org/10.1097/TP.0000000000004383 .
Kuniduzi Y , Chen B , Zeng J , et al . Efficacy and safety of a fourth dose of the COVID-19 vaccine in kidney transplant recipients:a systematic review and meta-analysis [J]. Transpl Immunol , 2023 , 79 : 101864 . doi: 10.1016/j.trim.2023.101864 http://dx.doi.org/10.1016/j.trim.2023.101864 .
American Society of Transplantation . COVID-19:vaccine faq sheet [EB/OL]. https://www.myast.org/COVID-19-vaccine-faq-sheet https://www.myast.org/COVID-19-vaccine-faq-sheet ,[ 2020-12-08 ].
Kühn T , Speer C , Morath C , et al . Immune response to COVID-19 mrna vaccination in previous nonresponder kidney transplant recipients after short-term withdrawal of mycophenolic acid 1 and 3 months after an additional vaccine dose [J]. Transplantation , 2023 , 107 ( 5 ): 1139 - 1150 . doi: 10.1097/TP.0000000000004516 http://dx.doi.org/10.1097/TP.0000000000004516 .
Tang Y , Li Y , Song T . Optimizing the use of nirmatrelvir/ritonavir
in solid organ transplant recipients with COVID-19:a review of immunosuppressant adjustment strategies [J]. Front Immunol , 2023 , 14 : 1150341 . doi: 10.3389/fimmu.2023.1150341 http://dx.doi.org/10.3389/fimmu.2023.1150341 .
Lemaitre F , Grégoire M , Monchaud C , et al . Management of drug-drug interactions with nirmatrelvir/ritonavir in patients treated for COVID-19:guidelines from the french society of pharmacology and therapeutics (sfpt) [J]. Therapie , 2022 , 77 ( 5 ): 509 - 521 . doi: 10.1016/j.therap.2022.03.005 http://dx.doi.org/10.1016/j.therap.2022.03.005 .
Dhand A , Okumura K , Ohira S , et al . Molnupiravir for treatment of COVID-19 in solid organ transplant recipients [J]. Transplantation , 2023 , 107 ( 6 ): e182 - e183 . doi: 10.1097/TP.0000000000004588 http://dx.doi.org/10.1097/TP.0000000000004588 .
杨猛 , 赵洪雯 , 徐泽良 , 等 . 阿兹夫定治疗肾移植受者中型新型冠状病毒感染的疗效及安全性分析 [J]. 中国临床新医学 , 2023 , 16 ( 10 ): 1011 - 1015 . doi: 10.3969/j.issn.1674-3806.2023.10.06 http://dx.doi.org/10.3969/j.issn.1674-3806.2023.10.06 .
Villamarín M , Márquez-Algaba E , Esperalba J , et al . Preliminary clinical experience of molnupiravir to prevent progression of COVID-19 in kidney transplant recipients [J]. Transplantation , 2022 , 106 ( 11 ): 2200 - 2204 . doi: 10.1097/TP.0000000000004306 http://dx.doi.org/10.1097/TP.0000000000004306 .
Jayk Bernal A , Gomes Da Silva MM , Musungaie DB , et al . Molnupiravir for oral treatment of COVID-19 in nonhospitalized patients [J]. N Engl J M , 2022 , 386 ( 6 ): 509 - 520 . doi: 10.1056/NEJMoa2116044 http://dx.doi.org/10.1056/NEJMoa2116044 .
Chen Z , Tian F . Efficacy and safety of azvudine in patients with COVID-19:a systematic review and meta-analysis [J]. Heliyon , 2023 , 9 ( 9 ): e20153 . doi: 10.1016/j.heliyon.2023.e20153 http://dx.doi.org/10.1016/j.heliyon.2023.e20153 .
Zhang JL , Li YH , Wang LL , et al . Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients [J]. Signal Transduct Target Ther , 2021 , 6 ( 1 ): 414 . doi: 10.1038/s41392-021-00835-6 http://dx.doi.org/10.1038/s41392-021-00835-6 .
巨春蓉 , 徐鑫 , 薛武军 . 实体器官移植受者感染新型冠状病毒的诊疗策略 [J]. 器官移植 , 2023 , 14 ( 2 ): 183 - 193 . doi: 10.3969/j.issn.1674-7445.2023.02.002 http://dx.doi.org/10.3969/j.issn.1674-7445.2023.02.002 .
陈慧俊 , 付嘉钊 , 隋明星 , 等 . 肾移植术后新型冠状病毒重症感染11例诊治报告 [J]. 中华器官移植杂志 , 2023 , 44 ( 11 ): 694 - 697 . doi: 10.3760/cma.j.cn421203-20230530-00117 http://dx.doi.org/10.3760/cma.j.cn421203-20230530-00117 .
Yin S , Wang X , Song T . Tacrolimus use and COVID-19 infection in patients after solid organ transplantation [J]. Gastroenterology , 2021 , 161 ( 2 ): 728 - 730.e1 . doi: 10.1053/j.gastro.2021.01.223 http://dx.doi.org/10.1053/j.gastro.2021.01.223 .
Requião-Moura LR , Modelli De Andrade LG , De Sandes-Freitas TV , et al . The mycophenolate-based immunosuppressive regimen is associated with increased mortality in kidney transplant patients with COVID-19 [J]. Transplantation , 2022 , 106 ( 10 ): e441 - e451 . doi: 10.1097/TP.0000000000004251 http://dx.doi.org/10.1097/TP.0000000000004251 .
国家传染病医学中心 , 中华医学会器官移植学分会 , 中国康复医学会器官移植康复专业委员会 , 等 . 实体器官移植受者新型冠状病毒感染诊疗专家共识(2023年版) [J]. 器官移植 , 2023 , 14 ( 2 ): 163 - 182 . doi: 10.3969/j.issn.1674-7445.2023.02.001 http://dx.doi.org/10.3969/j.issn.1674-7445.2023.02.001 .
国家卫生健康委 , 国家中医药局 . 新型冠状病毒感染诊疗方案(试行第十版) [J]. 传染病信息 , 2023 , 36 ( 1 ): 18 - 25 . doi: 10.3969/j.issn.1007-8134.2023.01.02 http://dx.doi.org/10.3969/j.issn.1007-8134.2023.01.02 .
巨春蓉 , 王梅英 , 袁静 , 等 . 免疫缺陷人群新型冠状病毒感染诊治策略中国专家共识(2023.v2版) [J]. 中国感染控制杂志 , 2023 , 22 ( 12 ): 1411 - 1424 . doi: 10.12138/j.issn.1671-9638.20234364 http://dx.doi.org/10.12138/j.issn.1671-9638.20234364
Ledford H . Long COVID is a double curse in low-income nations-here's why [J]. Nature , 2024 , 625 ( 7993 ): 20 - 22 . doi: 10.1038/d41586-023-04088-x http://dx.doi.org/10.1038/d41586-023-04088-x .
Ayoubkhani D , Bermingham C , Pouwels KB , et al . Trajectory of long COVID symptoms after COVID-19 vaccination:community based cohort study [J]. BMJ , 2022 , 377 : e069676 . doi: 10.1136/bmj-2021-069676 http://dx.doi.org/10.1136/bmj-2021-069676 .
Tran VT , Perrodeau E , Saldanha J , et al . Efficacy of COVID-19 vaccination on the symptoms of patients with long COVID:a target trial emulation using data from the compare e-cohort in franc [Z/OL]. https://europepmc.org/article/PPR/PPR418609 ,( 2021 )[ 2024-03-02 ]. doi: 10.2139/ssrn.3932953 http://dx.doi.org/10.2139/ssrn.3932953 .
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621