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1.滨州医学院第一临床医学院,山东 滨州 256600
2.滨州医学院附属医院介入血管外科,山东 滨州 256600
徐英江,E-mail:xuyingjiang@126.com
收稿日期:2024-01-26,
纸质出版日期:2025-06-25
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姜萌昕,董圣军,徐俊卿等.氨基酸在糖脂代谢紊乱中的作用研究进展[J].局解手术学杂志,2025,34(06):552-557.
JIANG Meng-xin,DONG Sheng-jun,XU Jun-qing,et al.Research progress on the role of amino acids in glycolipid metabolism disorders[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(06):552-557.
姜萌昕,董圣军,徐俊卿等.氨基酸在糖脂代谢紊乱中的作用研究进展[J].局解手术学杂志,2025,34(06):552-557. DOI: 10.11659/jjssx.01E024126.
JIANG Meng-xin,DONG Sheng-jun,XU Jun-qing,et al.Research progress on the role of amino acids in glycolipid metabolism disorders[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(06):552-557. DOI: 10.11659/jjssx.01E024126.
氨基酸作为细胞功能的代谢调节因子,在维持葡萄糖稳态、蛋白质合成、生殖、免疫和激素分泌等过程中发挥着至关重要的作用。近年来,氨基酸代谢在糖脂代谢紊乱发生发展中的作用成为研究热点。糖脂代谢紊乱是肥胖和糖尿病等代谢性疾病共同的核心病理机制,也是心血管疾病、肿瘤等的风险因素。本文将深入探讨各类氨基酸在糖脂代谢紊乱中的作用,阐述氨基酸调控机体代谢的具体机制,并分析其在疾病预防、协助诊断和治疗等方面的潜在作用,以期为进一步研究氨基酸在相关领域的应用提供参考。
As metabolic regulators of cellular functions, amino acids play a crucial role in maintaining glucose homeostasis, protein synthesis, reproduction, immunity, and hormone secretion.In recent years, the role of amino acid metabolism in the occurrence and development of glycolipid metabolism disorders has become a research hotspot.Glycolipid metabolism disorders represent the common core pathological mechanism of metabolic diseases such as obesity and diabetes, and also serve as risk factors for cardiovascular diseases and malignancies.This review focuses on the role of various amino acids in glycolipid metabolism disorders, elaborates the specific mechanism of amino acids in regulating the body's metabolism, and analyzes their potential roles in disease prevention, diagnosis and treatment, in order to provide reference for further research on the application of amino acids in related fields.
Chen K , Shen Z , Gu W , et al . Prevalence of obesity and associated complications in China:a cross-sectional, real-world study in 15.8 million adults [J]. Diabetes Obes Metab , 2023 , 25 ( 11 ): 3390 - 3399 . doi: 10.1111/dom.15238 http://dx.doi.org/10.1111/dom.15238 .
Simonson M , Boirie Y , Guillet C . Protein,amino acids and obesity treatment [J]. Rev Endocr Metab Disord , 2020 , 21 ( 3 ): 341 - 353 . doi: 10.1007/s11154-020-09574-5 http://dx.doi.org/10.1007/s11154-020-09574-5 .
Mcgarrah RW , White PJ . Branched-chain amino acids in cardiovascular disease [J]. Nat Rev Cardiol , 2023 , 20 ( 2 ): 77 - 89 . doi: 10.1038/s41569-022-00760-3 http://dx.doi.org/10.1038/s41569-022-00760-3 .
Mosley JD , Shi M , Agamasu D , et al . Branched-chain amino acids and type 2 diabetes:a bidirectional mendelian randomization analysis [J]. Obesity (Silver Spring) , 2024 , 32 ( 2 ): 423 - 435 . doi: 10.1002/oby. 23951 http://dx.doi.org/10.1002/oby.23951 .
Bugajska J , Berska J , Wójcik M , et al . Amino acid profile in overweight and obese prepubertal children: can simple biochemical tests help in the early prevention of associated comorbidities? [J]. Front Endocrinol (Lausanne) , 2023 , 14 : 1274011 . doi: 10.3389/fendo.2023.1274011 http://dx.doi.org/10.3389/fendo.2023.1274011 .
Bacha F , El-Ayash H , Mohamad M , et al . Distinct amino acid profile characterizes youth with or at risk for type 2 diabetes [J]. Diabetes , 2024 , 73 ( 4 ): 628 - 636 . doi: 10.2337/db23-0375 http://dx.doi.org/10.2337/db23-0375 .
Felig P , Marliss E , Cahill GJ . Plasma amino acid levels and insulin secretion in obesity [J]. N Engl J Med , 1969 , 281 ( 15 ): 811 - 816 . doi: 10.1056/NEJM196910092811503 http://dx.doi.org/10.1056/NEJM196910092811503 .
Mikkola TM , Salonen MK , Kajantie E , et al . Associations of fat and lean body mass with circulating amino acids in older men and women [J]. J Gerontol A Biol Sci Med Sci , 2020 , 75 ( 5 ): 885 - 891 . doi: 10.1093/gerona/glz126 http://dx.doi.org/10.1093/gerona/glz126 .
Biswas D , Duffley L , Pulinilkunnil T . Role of branched-chain amino acid:catabolizing enzymes in intertissue signaling,metabolic remodeling,and energy homeostasis [J]. FASEB J , 2019 , 33 ( 8 ): 8711 - 8731 . doi: 10.1096/fj.201802842RR http://dx.doi.org/10.1096/fj.201802842RR .
Fung E , Ng KH , Kwok T , et al . Divergent survival outcomes associated with elevated branched-chain amino acid levels among older adults with or without hypertension and diabetes:a validated, prospective,longitudinal follow-up study [J]. Biomolecules , 2023 , 13 ( 8 ): 1252 . doi: 10.3390/biom13081252 http://dx.doi.org/10.3390/biom13081252 .
Becetti I , Lauze M , Lee H , et al . Changes in branched-chain amino acids one year after sleeve gastrectomy in youth with obesity and their association with changes in insulin resistance [J]. Nutrients , 2023 , 15 ( 17 ): 3801 . doi: 10.3390/nu15173801 http://dx.doi.org/10.3390/nu15173801 .
Neinast MD , Jang C , Hui S , et al . Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids [J]. Cell Metab , 2019 , 29 ( 2 ): 417 - 429 . doi: 10.1016/j.cmet.2018.10.013 http://dx.doi.org/10.1016/j.cmet.2018.10.013 .
White PJ , Lapworth AL , An J , et al . Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export [J]. Mol Metab , 2016 , 5 ( 7 ): 538 - 551 . doi: 10.1016/j.molmet. 2016.04.006 http://dx.doi.org/10.1016/j.molmet.2016.04.006 .
Jang C , Oh SF , Wada S , et al . A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance [J]. Nat Med , 2016 , 22 ( 4 ): 421 - 426 . doi: 10.1038/nm. 4057 http://dx.doi.org/10.1038/nm.4057 .
Guertin DA , Sabatini DM . Defining the role of mTOR in cancer [J]. Cancer Cell , 2007 , 12 ( 1 ): 9 - 22 . doi: 10.1016/j.ccr.2007.05.008 http://dx.doi.org/10.1016/j.ccr.2007.05.008 .
Cheng Z , Tseng Y , White MF . Insulin signaling meets mitochondria in metabolism [J]. Trends Endocrinol Metab , 2010 , 21 ( 10 ): 589 - 598 . doi: 10.1016/j.tem.2010.06.005 http://dx.doi.org/10.1016/j.tem.2010.06.005 .
Sancak Y , Bar-Peled L , Zoncu R , et al . Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids [J]. Cell , 2010 , 141 ( 2 ): 290 - 303 . doi: 10.1016/j.cell.2010.02.024 http://dx.doi.org/10.1016/j.cell.2010.02.024 .
Fiehn O , Garvey WT , Newman JW , et al . Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women [J]. PLoS One , 2010 , 5 ( 12 ): e15234 . doi: 10.1371/journal.pone.0015234 http://dx.doi.org/10.1371/journal.pone.0015234 .
Stabler SP . Alterations in sulfur amino acids as biomarkers of disease [J]. J Nutr , 2020 , 150 ( Suppl 1 ): 2532S - 2537S . doi: 10.1093/jn/nxaa118 http://dx.doi.org/10.1093/jn/nxaa118 .
Olsen T , Stolt E , Øvrebø B , et al . Dietary sulfur amino acid restriction in humans with overweight and obesity:a translational randomized controlled trial [J]. J Transl Med , 2024 , 22 ( 1 ): 40 . doi: 10.1186/s12967-023-04833-w http://dx.doi.org/10.1186/s12967-023-04833-w .
Tore EC , Eussen S , Bastani NE , et al . The associations of habitual intake of sulfur amino acids,proteins and diet quality with plasma sulfur amino acid concentrations:the Maastricht study [J]. J Nutr , 2023 , 153 ( 7 ): 2027 - 2040 . doi: 10.1016/j.tjnut.2023.05.008 http://dx.doi.org/10.1016/j.tjnut.2023.05.008 .
Castaño-Martinez T , Schumacher F , Schumacher S , et al . Methionine restriction prevents onset of type 2 diabetes in NZO mice [J]. FASEB J , 2019 , 33 ( 6 ): 7092 - 7102 . doi: 10.1096/fj.201900150R http://dx.doi.org/10.1096/fj.201900150R .
Ceddia RB , Somwar R , Maida A , et al . Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells [J]. Diabetologia , 2005 , 48 ( 1 ): 132 - 139 . doi: 10.1007/s00125-004-1609-y http://dx.doi.org/10.1007/s00125-004-1609-y .
Yang Y , Zhang Y , Xu Y , et al . Dietary methionine restriction improves the gut microbiota and reduces intestinal permeability and inflammation in high-fat-fed mice [J]. Food Funct , 2019 , 10 ( 9 ): 5952 - 5968 . doi: 10.1039/c9fo00766k http://dx.doi.org/10.1039/c9fo00766k .
Yang Y , Wang Y , Sun J , et al . Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting H2S production [J]. Food Funct , 2019 , 10 ( 1 ): 61 - 77 . doi: 10.1039/c8fo01629a http://dx.doi.org/10.1039/c8fo01629a .
Xu Y , Yang Y , Sun J , et al . Dietary methionine restriction ameliorates the impairment of learning and memory function induced by obesity in mice [J]. Food Funct , 2019 , 10 ( 3 ): 1411 - 1425 . doi: 10.1039/c8fo01922c http://dx.doi.org/10.1039/c8fo01922c .
Sharma S , Dixon T , Jung S , et al . Dietary methionine restriction reduces inflammation independent of FGF21 action [J]. Obesity , 2019 , 27 ( 8 ): 1305 - 1313 . doi: 10.1002/oby.22534 http://dx.doi.org/10.1002/oby.22534 .
Olas B . Hydrogen sulfide in signaling pathways [J]. Clin Chim Acta , 2015 , 439 : 212 - 218 . doi: 10.1016/j.cca.2014.10.037 http://dx.doi.org/10.1016/j.cca.2014.10.037 .
Olsen T , Øvrebø B , Turner C , et al . Combining dietary sulfur amino acid restriction with polyunsaturated fatty acid intake in humans:a randomized controlled pilot trial [J]. Nutrients , 2018 , 10 ( 12 ): 1822 . doi: 10.3390/nu10121822 http://dx.doi.org/10.3390/nu10121822 .
Menge BA , Schrader H , Ritter PR , et al . Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes [J]. Regul Pept , 2010 , 160 ( 1/3 ): 75 - 80 . doi: 10.1016/j.regpep.2009.08.001 http://dx.doi.org/10.1016/j.regpep.2009.08.001 .
Newgard CB , An J , Bain JR , et al . A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance [J]. Cell Metab , 2009 , 9 ( 4 ): 311 - 326 . doi: 10.1016/j.cmet.2009.02.002 http://dx.doi.org/10.1016/j.cmet.2009.02.002 .
Tai ES , Tan ML , Stevens RD , et al . Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men [J]. Diabetologia , 2010 , 53 ( 4 ): 757 - 767 . doi: 10.1007/s00125-009-1637-8 http://dx.doi.org/10.1007/s00125-009-1637-8 .
Li R , Huang X , Liang X , et al . Integrated omics analysis reveals the alteration of gut microbe-metabolites in obese adults [J]. Brief Bioinform , 2021 , 22 ( 3 ): bbaa165 . doi: 10.1093/bib/bbaa165 http://dx.doi.org/10.1093/bib/bbaa165 .
Wu J , Li Z , Zhu H , et al . Childhood overweight and obesity:age stratification contributes to the differences in metabolic characteristics [J]. Obesity (Silver Spring) , 2024 , 32 ( 3 ): 571 - 582 . doi: 10.1002/oby.23964 http://dx.doi.org/10.1002/oby.23964 .
Wang TJ , Larson MG , Vasan RS , et al . Metabolite profiles and the risk of developing diabetes [J]. Nat Med , 2011 , 17 ( 4 ): 448 - 453 . doi: 10.1038/nm.2307 http://dx.doi.org/10.1038/nm.2307 .
Ndlovu IS , Tshilwane SI , Vosloo A , et al . Metabolomics of type 2 diabetes mellitus in sprague dawley rats-in search of potential metabolic biomarkers [J]. Int J Mol Sci , 2023 , 24 ( 15 ): 12467 . doi: 10.3390/ijms241512467 http://dx.doi.org/10.3390/ijms241512467 .
Wijekoon EP , Skinner C , Brosnan ME , et al . Amino acid metabolism in the Zucker diabetic fatty rat:effects of insulin resistance and of type 2 diabetes [J]. Can J Physiol Pharmacol , 2004 , 82 ( 7 ): 506 - 514 . doi: 10.1139/y04-067 http://dx.doi.org/10.1139/y04-067 .
Cussotto S , Delgado I , Anesi A , et al . Tryptophan metabolic pathways are altered in obesity and are associated with systemic inflammation [J]. Front Immunol , 2020 , 11 : 557 . doi: 10.3389/fimmu.2020. 00557 http://dx.doi.org/10.3389/fimmu.2020.00557 .
Lischka J , Schanzer A , Baumgartner M , et al . Tryptophan metabolism is associated with BMI and adipose tissue mass and linked to metabolic disease in pediatric obesity [J]. Nutrients , 2022 , 14 ( 2 ): 286 . doi: 10.3390/nu14020286 http://dx.doi.org/10.3390/nu14020286 .
Arto C , Rusu EC , Clavero-Mestres H , et al . Metabolic profiling of tryptophan pathways:implications for obesity and metabolic dysfunction-associated steatotic liver disease [J]. Eur J Clin Invest , 2024 , 54 ( 11 ): e14279 . doi: 10.1111/eci.14279 http://dx.doi.org/10.1111/eci.14279 .
Pan Q , Liu Q , Wan R , et al . Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice [J]. Metab Brain Dis , 2019 , 34 ( 3 ): 747 - 761 . doi: 10.1007/s11011-019-0392-x http://dx.doi.org/10.1007/s11011-019-0392-x .
Konopelski P , Konop M , Gawrys-Kopczynska M , et al . Indole-3-propionic acid,a tryptophan-derived bacterial metabolite,reduces weight gain in rats [J]. Nutrients , 2019 , 11 ( 3 ): 591 . doi: 10.3390/nu11030591 http://dx.doi.org/10.3390/nu11030591 .
Solon-Biet SM , Cogger VC , Pulpitel T , et al . Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control [J]. Nat Metab , 2019 , 1 ( 5 ): 532 - 545 . doi: 10.1038/s42255-019-0059-2 http://dx.doi.org/10.1038/s42255-019-0059-2 .
Green CL , Lamming DW . Regulation of metabolic health by essential dietary amino acids [J]. Mech Ageing Dev , 2019 , 177 : 186 - 200 . doi: 10.1016/j.mad.2018.07.004 http://dx.doi.org/10.1016/j.mad.2018.07.004 .
Brown-Borg HM , Buffenstein R . Cutting back on the essentials:can manipulating intake of specific amino acids modulate health and lifespan? [J]. Ageing Res Rev , 2017 , 39 : 87 - 95 . doi: 10.1016/j.arr.2016.08.007 http://dx.doi.org/10.1016/j.arr.2016.08.007 .
Zapata RC , Singh A , Ajdari NM , et al . Dietary tryptophan restriction dose-dependently modulates energy balance,gut hormones,and microbiota in obesity-prone rats [J]. Obesity , 2018 , 26 ( 4 ): 730 - 739 . doi: 10.1002/oby.22136 http://dx.doi.org/10.1002/oby.22136 .
Ottosson F , Smith E , Melander O , et al . Altered asparagine and glutamate homeostasis precede coronary artery disease and type 2 diabetes [J]. J Clin Endocrinol Metab , 2018 , 103 ( 8 ): 3060 - 3069 . doi: 10.1210/jc.2018-00546 http://dx.doi.org/10.1210/jc.2018-00546 .
Schneeberger M , Brice NL , Pellegrino K , et al . Author correction:pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction [J]. Nat Metab , 2023 , 5 ( 1 ): 183 . doi: 10.1038/s42255-022-00727-1 http://dx.doi.org/10.1038/s42255-022-00727-1 .
van den Pol AN , Acuna C , Davis JN , et al . Defining the caudal hypothalamic arcuate nucleus with a focus on anorexic excitatory neurons [J]. J Physiol , 2019 , 597 ( 6 ): 1605 - 1625 . doi: 10.1113/JP277152 http://dx.doi.org/10.1113/JP277152 .
Gao J , Zhang S , Deng P , et al . Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion [J]. Nat Commun , 2024 , 15 ( 1 ): 3514 . doi: 10.1038/s41467-024-47465-4 http://dx.doi.org/10.1038/s41467-024-47465-4 .
Gaggini M , Carli F , Rosso C , et al . Altered amino acid concentrations in NAFLD:impact of obesity and insulin resistance [J]. Hepatology , 2018 , 67 ( 1 ): 145 - 158 . doi: 10.1002/hep.29465 http://dx.doi.org/10.1002/hep.29465 .
Wang Z , Yang Q . The causal relationship between human blood metabolites and the risk of visceral obesity:a mendelian randomization analysis [J]. Lipids Health Dis , 2024 , 23 ( 1 ): 39 . doi: 10.1186/s12944-024-02035-x http://dx.doi.org/10.1186/s12944-024-02035-x .
Deutz LN , Wierzchowska-Mcnew RA , Deutz NE , et al . Reduced plasma glycine concentration in healthy and chronically diseased older adults:a marker of visceral adiposity? [J]. Am J Clin Nutr , 2024 , 119 ( 6 ): 1455 - 1464 . doi: 10.1016/j.ajcnut.2024.04.008 http://dx.doi.org/10.1016/j.ajcnut.2024.04.008 .
Okekunle AP , Li Y , Liu L , et al . Abnormal circulating amino acid profiles in multiple metabolic disorders [J]. Diabetes Res Clin Pract , 2017 , 132 : 45 - 58 . doi: 10.1016/j.diabres.2017.07.023 http://dx.doi.org/10.1016/j.diabres.2017.07.023 .
Guasch-Ferre M , Hruby A , Toledo E , et al . Metabolomics in prediabetes and diabetes:a systematic review and meta-analysis [J]. Diabetes Care , 2016 , 39 ( 5 ): 833 - 846 . doi: 10.2337/dc15-2251 http://dx.doi.org/10.2337/dc15-2251 .
Lever M , Slow S , Mcgregor DO , et al . Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses:an observational study [J]. Cardiovasc Diabetol , 2012 , 11 : 34 . doi: 10.1186/1475-2840-11-34 http://dx.doi.org/10.1186/1475-2840-11-34 .
Magnusson M , Wang TJ , Clish C , et al . Dimethylglycine deficiency and the development of diabetes [J]. Diabetes , 2015 , 64 ( 8 ): 3010 - 3016 . doi: 10.2337/db14-1863 http://dx.doi.org/10.2337/db14-1863 .
Ejaz A , Martinez-Guino L , Goldfine AB , et al . Dietary betaine supplementation increases Fgf21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice [J]. Diabetes , 2016 , 65 ( 4 ): 902 - 912 . doi: 10.2337/db15-1094 http://dx.doi.org/10.2337/db15-1094 .
Garcia E , Oste M , Bennett DW , et al . High betaine,a trimethylamine N-Oxide related metabolite,is prospectively associated with low future risk of type 2 diabetes mellitus in the PREVEND study [J]. J Clin Med , 2019 , 8 ( 11 ): 1813 . doi: 10.3390/jcm8111813 http://dx.doi.org/10.3390/jcm8111813 .
Alves A , Bassot A , Bulteau A , et al . Glycine metabolism and its alterations in obesity and metabolic diseases [J]. Nutrients , 2019 , 11 ( 6 ): 1356 . doi: 10.3390/nu11061356 http://dx.doi.org/10.3390/nu11061356 .
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