Objective     To observe the bacteriostatic effect of compound ornidazole and pefloxacinmesylate sustained-release gum suppository.      Methods     The sustained-release

sensitive stability of bacteria

ground substance effect of the suppository were tested by using Kirby-Bauer paper dispersed method.      Results     The gum suppository had significant bacteriostatic effect on

Porphyromonsa gingivals

and other bacteria. The sustained-release time was above 12 h. The gum suppository still had bacteriostatic effect after preserved for 6 months at 4 ℃

with no significant difference in compared with 6 months before

. The ground substance effect test discovered that the bacteriostatic effect of adding ground substance group was weaker than that of no adding ground substance group to

Staphylococcus aureus

Porphyromonsa gingivals

Fusobacterium nucleatum

Peptostreptococcus spp

(

P

＜0.05)

but the bacteriostatic effect was no significant different between adding ground substance group and no adding ground substance group to

Staphylococcus epidermidis

Prevotells intermedia

and

Streptococcus mutans

.      Conclusion     Compound ornidazole and pelfloxacinmesylate sustained-release gum suppository had significant bacteriostatic effect

with delayed release

better stability

and no influence on the ground substance.