LIU EN-MEI, XIE XIAO-HONG, DENG BIN, et al. Clinical analyses on human metapneumovirus infection in acute respiratory tract of 25 children. [J]. Journal of army medical university, 2007, 29(16): 1609-1611.
LIU EN-MEI, XIE XIAO-HONG, DENG BIN, et al. Clinical analyses on human metapneumovirus infection in acute respiratory tract of 25 children. [J]. Journal of army medical university, 2007, 29(16): 1609-1611.DOI:
epidemiologic and clinical features of human metapneumovirus (hMPV) in children’s respiratory tract. Method Nasopharyngeal aspirates (NPS) from 258 hospitalized children with respiratory diseases over 13 months from 2002 December to 2003 December in our hospital were collected. Rapid immunofluoresence method was used to diagnose respiratory syncytial virus (RSV)
adenovirus
influenza A and B
and parainfluenza 1
2
3. Viral mRNAs from NPS was extracted. L and M gene of hMPV
coronavirus and rhinovirus were detected by RT-PCR. Results hMPV was detected in the NPS from 25 (9.7%) children by PCR. hMPV infection was associated with clinical diagnosis of pneumonia (36%)
asthma exacerbation (16%) and acute bronchiolitis. Fifteen children with hMPV infection were co-infected with RSV
rhinovirus
coronavirus and RSV plus rhinovirus respectively. hMPV viral activity peaked during the autumn-winter period in Chongqing. Conclusion These data suggest besides RSV
hMPV is the common pathogen of children with respiratory infection. hMPV could be co-infected with other viruses. Further study will be elucidated the sequela of single hMPV infection and co-infection with other viruses.
关键词
人偏肺病毒呼吸道感染儿童
Keywords
human metapneumovirusrespiratory infectionchildren