Objective    To investigate the effect of a novel isoflavone compound (F11) on the plasma lipid and cholesterol of the ovarectomied rat.     Methods    Female SD rats at age of 3 months old were randomly divided into 6 groups

that is

sham operation group (Sham)

normal saline group (2 ml/d)

  estradiol group (E2

50 μg·kg

-1

·d

-1

)

and 3 F11 groups (15

50

150 mg·kg

-1

·d

-1

). Besides the Sham group

the ovary of the rats from other groups were resected

and received the injection as above mentioned. All rats were killed 10 weeks later

and their plasma lipid

total cholesterol

LDL

HDL

and body weight and uterine weight were measured.

     Results    The plasma lipid

total cholesterol

LDL

HDL were significantly different in normal saline group and 4 treatment group (P

<

0.05). Rats of normal saline group had elevated body weight and decreased uterine weight in comparison with sham group.     Conclusion    The novel compound F11 can decrease plasma lipid of ovarectomied rat

control body weight and resist the change of uterine.