Objective    To investigate the most effective flavonoids with catechol group for decorporating acute depleted uranium poisoning.     Methods    The effects on uranium decorporation of flavonoids with catechol group

chelating agent of catechols amino carboxylic acid type (8102)

dimethyl sulfoxide (DMSO)

which were all intraperitoneally injected for 3 d

were observed after depleted uranium (DU) exposure. Three days later

renal function examination and pathological observation of sensitive organs such as kidney

liver

spleen and bone marrow were carried out.     Results    Large reduction in urea nitrogen and serum creatinine was observed in 8102 and F1 groups

and serum creatinine decreased in F2

T1 and T2 groups. Pathological results showed that kidney

liver

spleen and bone marrow in T2 group had no obvious injury. Our experiment results suggested the most effective compound was T2

next 8102 and T1

then F1 and QU.     Conclusion    T2 compound well protects the organs sensitive to acute depleted uranium poisoning. F1 can improve renal functions. Therefore

they may be used as potential decorporation agents for uranium poisoning.