G蛋白激酶4基因多态性与高血压病相关性的Meta分析

石伟彬; 于长青; 曾春雨

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G蛋白激酶4基因多态性与高血压病相关性的Meta分析

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- G蛋白激酶4基因多态性与高血压病相关性的Meta分析
- Correlation between of G protein-coupled receptor kinases 4 polymorphism and essential hypertension: a Meta-analysis
- 陆军军医大学学报 2009年31卷第3期页码：191-193
- 作者机构：
  
  第三军医大学大坪医院野战外科研究所：心血管内科，心血管病研究室，急诊科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R181.33;R394;R544.1
- 纸质出版日期：2009，
  
  网络出版日期：2009-02-15，
- 稿件说明：
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石伟彬, 于长青, 曾春雨. G蛋白激酶4基因多态性与高血压病相关性的Meta分析[J]. 陆军军医大学学报, 2009,31(3):191-193.

SHI WEI-BIN, YU CHANG-QING, ZENG CHUN-YU. Correlation between of G protein-coupled receptor kinases 4 polymorphism and essential hypertension: a Meta-analysis. [J]. Journal of army medical university, 2009, 31(3): 191-193.
石伟彬, 于长青, 曾春雨. G蛋白激酶4基因多态性与高血压病相关性的Meta分析[J]. 陆军军医大学学报, 2009,31(3):191-193. DOI：

SHI WEI-BIN, YU CHANG-QING, ZENG CHUN-YU. Correlation between of G protein-coupled receptor kinases 4 polymorphism and essential hypertension: a Meta-analysis. [J]. Journal of army medical university, 2009, 31(3): 191-193. DOI：

摘要

目的综合评价G蛋白激酶4(G protein-coupled receptor kinases 4

GRK4 )基因多态性R65L、A486V、A142V与高血压病的相关性。方法检索Medline 1997-2006年关于GRK4基因多态性（R65L、A486V、A142V）与高血压病相关性的文献，应用RevMan 4.2软件对其进行Meta分析。结果共有4篇符合条件的文献纳入分析，累积病例857例，累积对照913例。GRK4变异体R65L、A142V、A486V 3个基因型频率的合并

值及95%

值分别为0.97（0.75~1.25，

=0.81）、0.81（0.30~2.08，

=0.65）和1.48（1.16~1.89，

=0.001）。结论 GRK4基因A486V多态性可能与原发性高血压相关

变异体A486V患者高血压病的危险性可能有增高趋势。

Abstract

Objective To access the relationship between the polymorphism of G protein-coupled receptor kinases 4 (GRK4

including R65L

A486V and A142V) and essential hypertension. Methods All the literature on the subjects was searched by key words such as essential hypertension

hypertension

G protein-coupled receptor kinases 4 gene

and polymorphism in the electronic databases

Medline of Year 1997 to 2006. RevMan 4.2 software was used for Meta analysis. Results A total of 857 cases and 913 controls from 4 studies were included. The ORs of genotypes of R65L

A142V and A

486V were 0.97 (0.75 to 1.25

=0.81)

0.81 (0.30 to 2.08

=0.65) and 1.48 (1.16 to 1.8

=0.001) respectively. Conclusion GRK4 gene polymorphism A486V is significantly associated with susceptibility of essential hypertension. People who carries A486V have a higher risk to be subject to essential hypertension.

关键词

G蛋白激酶4高血压病荟萃分析基因多态性

Keywords

G protein-coupled receptor kinases 4essential hypertensionMeta analysispolymorphism

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