醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察

胡蕾; 刘松青; 郭薇; 代青; 刘蕴佳

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醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察

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- 醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察
- Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate
- 陆军军医大学学报 2009年31卷第8期页码：706-709
- 作者机构：
  
  第三军医大学：西南医院药学部,学员旅12队
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R943;R944.9;R988.1
- 纸质出版日期：2009，
  
  网络出版日期：2009-04-30，
- 稿件说明：
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胡蕾, 刘松青, 郭薇, 等. 醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察[J]. 陆军军医大学学报, 2009,31(8):706-709.

HU LEI, LIU SONG-QING, GUO WEI, et al. Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate. [J]. Journal of army medical university, 2009, 31(8): 706-709.
胡蕾, 刘松青, 郭薇, 等. 醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察[J]. 陆军军医大学学报, 2009,31(8):706-709. DOI：

HU LEI, LIU SONG-QING, GUO WEI, et al. Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate. [J]. Journal of army medical university, 2009, 31(8): 706-709. DOI：

摘要

目的制备醋酸曲安奈德（triamcinolone-acetonide-acetate

TAA）-聚乳酸（polylactic acid

PLA）植入剂（Implant），考察醋酸曲安奈德植入剂的体外释药特性。方法采用熔融-挤出法制备TAA-PLA 植入剂，高效液相色谱法测定TAA含量，绘制体外释放曲线。结果制得的植入剂为直径0.8 mm，长约8 mm，质量约8 mg的白色柱状物，其中TAA的载药量为30%，体外释放速率平稳且缓慢，第30天时TAA的累积释放率为75.84%，药物体外释放符合Higuchi方程 Q = 0.137×(

-0.752)

1/2

。结论所制备的TAA-PLA 植入剂对药物TAA有明显的缓释效果，且在体内可生物降解，毒副作用小，有望成为TAA的眼部新型给药制剂。

Abstract

Objective To prepare a biodegradable sckeral implant containing triamcinolone-acetonide-acetate (TAA) and polylactic acid (PLA) and investigate its release

in vitro

. Methods The TAA-PLA implant was prepared by melt-extrude technique. The drug release of TAA

in vitro

was determined by high performance liquid chromatography (HPLC). Results The implant was white pillar with 8 mm in length

8 mg in weight

and 0.8 mm in diameter. The drug loading was 30%. The drug was released at a steady and slow rate. Its accumulation release rate is 75.84% on the 30th day. Drug release profile

in vitro

was in accordance

with Higuchi equation Q=0.137 (

-0.752)

1/2

. Conclusion A sleral implant containing TAA-PLA is prepared

which has the evident feature in delaying the release of TAA and is biological degradable. It might be a novel vehicle for the topical use of TAA.

关键词

聚乳酸醋酸曲安奈德眼色素层炎巩膜植入剂

Keywords

polylactic acidtriamcinolone acetonide acetateuveitisscleral implant

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