Objective    To investigate the difference of hypercoagulable state of the nephrotic syndrome patients who living at high altitude or in plain area in order to investigate the features of diagnosis and treatment for this disease at high altitude.     Methods    Nephrotic syndrome patients from the General Hospital of Tibetan Military Command (above sea level 3 680 m

high altitude group

n

=30) and Xinqiao Hospital (above sea level 300 m

plain group

n

=30) were enrolled in this study. Anothe

r 30 health individuals served as normal control. Prothrombin time (PT)

activated partial thromboplastin time (APTT)

and the levels of fibrinogen (Fib) and D-dimer

and content of antithrombin-Ⅲ (AT-Ⅲ) were detected simultaneously. The detected results from 3 groups were compared.     Results    There was no significantly differences in PT and APTT among the 3 groups (

P

>0.05)

and the levels of Fib and D-dimer were obviously higher but AT-Ⅲ was obviously lower in 2 NS groups than those in normal control group (

P

<

0.01). Compared with 2 groups of nephrotic syndrome

the level of Fib and D-dimer was higher

but AT-Ⅲ was lower significantly in high altitude group than those of the plain group (

P

<

0.01).     Conclusion    The activity of coagulation in nephrotic syndrome patients at high altitude is higher than those of nephrotic syndrome patients at the plain area.