CD68、CD163阳性巨噬细胞在食管癌组织浸润及对预后的影响

解瑞玲; 董伯升; 成媛; 庞慧; 李醒亚

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CD68、CD163阳性巨噬细胞在食管癌组织浸润及对预后的影响

论著 | 更新时间：2025-01-15

- CD68、CD163阳性巨噬细胞在食管癌组织浸润及对预后的影响
- Infiltrations of CD68- and CD163-positive macrophages in esophageal cancer tissue and their impacts on prognosis
- 陆军军医大学学报 2011年33卷第5期页码：523-526
- 作者机构：
  
  1. 郑州大学第一附属医院肿瘤科
  2. 周口中心医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R73-37;R735.1;R392.12
- 纸质出版日期：2011，
  
  网络出版日期：2011-03-15，
- 稿件说明：
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解瑞玲, 董伯升, 成媛, 等. CD68、CD163阳性巨噬细胞在食管癌组织浸润及对预后的影响[J]. 陆军军医大学学报, 2011,33(5):523-526.

XIE RUILING, DONG BOSHENG, CHENG YUAN, et al. Infiltrations of CD68- and CD163-positive macrophages in esophageal cancer tissue and their impacts on prognosis. [J]. Journal of army medical university, 2011, 33(5): 523-526.
解瑞玲, 董伯升, 成媛, 等. CD68、CD163阳性巨噬细胞在食管癌组织浸润及对预后的影响[J]. 陆军军医大学学报, 2011,33(5):523-526. DOI：

XIE RUILING, DONG BOSHENG, CHENG YUAN, et al. Infiltrations of CD68- and CD163-positive macrophages in esophageal cancer tissue and their impacts on prognosis. [J]. Journal of army medical university, 2011, 33(5): 523-526. DOI：

摘要

目的探讨CD68

CD163

巨噬细胞在食管癌组织浸润及其对预后的影响。方法应用免疫组化方法检测CD68

、CD163

巨噬细胞在食管癌组织的浸润，比较CD68、CD163阳性巨噬细胞浸润密度及对食管癌患者预后的影响。结果食管癌组织CD68、CD163阳性巨噬细胞浸润密度较癌旁正常组织明显增多（

=21.379

0.01;

=21.712

0.01)。 CD68

、CD163

巨噬细胞浸润密度与患者生存时间均呈负相关性(

=-0.281

0.01;

=-0.344

0.01)。CD68

、CD163

巨噬细胞浸润高密度组5年生存率低于低密度组，分别为30.5%

56.9%， 27.1% vs 60.3% (

0.05)，但COX风险因素分析CD68

巨噬细胞不是独立的预后因素(P>0.05)，而CD163

巨噬细胞是独立的预后因素(

0.01)。结论 CD68

、CD163

巨噬细胞在食管癌组织中具有较高的浸润密度，CD163

巨噬细胞浸润密度与患者预后具有密切相关性。

Abstract

Objective To investigate the infiltrations of CD68- and CD163-positive macrophages in esophageal cancer tissue and their impacts on prognosis. Methods One hundred and seventeen esophageal cancer specimens were resected from January 1

2004 to May 30

2005 in our hospital and

Henan Tumor Hospital. The infiltration densities of CD68- and CD163-positive macrophages in each esophageal cancer specimen were measured by immunohistochemical staining

and the specimens were divided into high-density and low-density groups for CD68-positive macrophages and CD163-positive macrophages. Homogeneity of variance test and student’s

-test

Spearman’s test

Kaplan-Meier survival analysis

and Cox regression analysis were used to compare the infiltration densities of CD68- and CD163-positive macrophages in esophageal cancer tissue with those in adjacent normal tissue and evaluate the impacts of infiltration densities of CD68- and CD163-positive macrophages on prognosis of esophageal cancer. Results The infiltration densities of CD68- and CD163-positive macrophages were significantly higher in esophageal cancer tissue than in adjacent normal tissue (

=21.379

0.01;

=21.712

0.01). The infiltration densities of CD68- and CD163-positive macrophages were negatively correlated with the survival times of patients (

=-0.281

0.01;

=-0.344

0.01). The 5-year survival rate was lower in high-density groups than in low-density groups for both CD68-positive macrophages and CD163-positive macrophages (30.5%

56.9%

0.05; 27.1%

60.3%

0.05). The infiltration density of CD68-positive macrophages was not an independent prognostic factor (

>0.05)

but that of CD163-positive macrophages was (

0.05)

according to Cox regression analysis. Conclusion CD68- and CD163-positive macrophages show relatively high infiltration densities in esophageal cancer tissue. The infiltration density of CD163-positive macrophages is negatively correlated with the prognosis of esophageal cancer.

关键词

食管癌CD68CD163巨噬细胞浸润免疫组化预后

Keywords

esophageal carcinomaCD68CD163macrophagesinfiltrationimmunohistochemistryprognosis

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