血清骨形成蛋白-7浓度与女性肥胖的相关性研究

曾俊; 姜友昭; 陈兵

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血清骨形成蛋白-7浓度与女性肥胖的相关性研究

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- 血清骨形成蛋白-7浓度与女性肥胖的相关性研究
- Correlation between concentration of serum bone morphogenetic protein-7 and obesity in adult women
- 陆军军医大学学报 2011年33卷第8期页码：857-860
- 作者机构：
  
  第三军医大学西南医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R181.38;R341;R589.2
- 纸质出版日期：2011，
  
  网络出版日期：2011-04-30，
- 稿件说明：
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曾俊, 姜友昭, 陈兵. 血清骨形成蛋白-7浓度与女性肥胖的相关性研究[J]. 陆军军医大学学报, 2011,33(8):857-860.

ZENG JUN, JIANG YOUZHAO, CHEN BING. Correlation between concentration of serum bone morphogenetic protein-7 and obesity in adult women. [J]. Journal of army medical university, 2011, 33(8): 857-860.
曾俊, 姜友昭, 陈兵. 血清骨形成蛋白-7浓度与女性肥胖的相关性研究[J]. 陆军军医大学学报, 2011,33(8):857-860. DOI：

ZENG JUN, JIANG YOUZHAO, CHEN BING. Correlation between concentration of serum bone morphogenetic protein-7 and obesity in adult women. [J]. Journal of army medical university, 2011, 33(8): 857-860. DOI：

摘要

目的检测女性血清骨形成蛋白-7浓度，探讨骨形成蛋白-7与女性肥胖的相关性。方法选取女性肥胖者65例，以体质量指数正常女性134例作为对照组。记录年龄、腰围、臀围、身高、体质量等人体学指标，计算腰臀比和体质指数。测定血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血糖、尿酸等代谢指标，酶联免疫吸附试验（enzyme-linked immunosorbent assay，ELISA）检测血清骨形成蛋白-7浓度，比较两组间指标的差异以及血清骨形成蛋白-7和代谢性指标的相关性。结果肥胖组血清骨形成蛋白-7浓度明显低于正常对照组(P

0.01) 。女性血清骨形成蛋白-7浓度与年龄、体质指数、收缩压、腰围、总胆固醇、低密度脂蛋白胆固醇均存在负相关(

值分别为-0.181、-0.248、-0.143、-0.148、-0.169、-0.177，

0.05)，多元线性回归分析显示通过年龄、体质指数、收缩压、腰围、总胆固醇、低密度脂蛋白胆固醇、舒张压、平均动脉压、腰臀比、尿酸、甘油三酯、高密度脂蛋白胆固醇、空腹血糖校正后，血清骨形成蛋白-7仍和体质指数负相关（

=-0.248，

0.01）。结论女性血清骨形成蛋白-7浓度与体质指数负相关，提示血清骨形成蛋白-7可能作为治疗女性肥胖的潜在靶点。

Abstract

Objective To measure serum bone morphogenetic protein-7 (BMP-7) concentration in adult women and to determine correlation between BMP-7 concentration and obesity

so as to provide a new target for obesity therapy. Methods Sixty-five obese women were enrolled in an obesity group

and one hundred and thirty-four adult women having normal body mass indexes were enrolled in a control group. Clinical data including age

height

wei

ght

systolic blood pressure

diastolic blood pressure

waist circumference

and hip circumference were recorded. Then body mass index and waist-hip ratio were calculated. Metabolic parameters such as serum total cholesterol

triglyceride

LDL-cholesterol

HDL-cholesterol

fasting glucose

and uric acid were tested. Serum BMP-7 concentration was detected through enzyme-linked immunosorbent assay (ELISA). The parameters of the two groups were compared. The correlation between serum BMP-7 concentration and metabolic parameters were analyzed. Results Serum BMP-7 concentration in the obesity group was significantly lower than that in the control group (

0.01). Serum BMP-7 concentration was negatively correlated with age

body mass index

systolic blood pressure

waist circumference

total cholesterol

and LDL-cholesterol (

=-0.181

-0.248

-0.143

-0.148

-0.169

and -0.177

respectively

0.05). Multiple stepwise regression analysis results showed that the body mass index was the only independent factor influencing the serum BMP-7 concentration after being adjusted by age

body mass index

systolic blood pressure

waist circumference

total cholesterol

LDL-cholesterol

diastolic blood pressure

mean arterial blood pressure

waist-hip ratio

uric acid

triglyceride

HDL-cholesterol

and fasting glucose. Conclusion In adult women

serum BMP-7 concentration is negatively correlated with body mass index

suggesting that BMP-7 may be a potential target for woman obesity therapy.

关键词

骨形成蛋白-7肥胖体质量指数

Keywords

bone morphogenetic protein-7obesitybody mass index

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