Objective      To investigate clinical features of lower extremity atherosclerotic occlusive disease in patients with type 2 diabetes me

llitus and hypertension.       Methods      We performed a retrospective analysis of 319 patients (223 males and 96 males

a mean age of over 68) with lower extremity atherosclerotic occlusive disease who were hospitalized in Departments of Endocrinology and Vascular Surgery of the First Affiliated Hospital

School of Medicine

Zhejiang University

between January 2004 to December 2010. These patients were divided into 4 groups

control group (without hypertension or diabetes

n

=50)

diabetes group (DM group

n

=48)

hypertension group (HNT

n

=80)

and diabetes and hypertension group (DM-HNT

n

=141). All these patients were examined by lower limbs color Doppler ultrasonography and/or magnetic resonance angiography (MRA)

and 248 patients (248/319) underwent arteriography on lower extremity. The differences in ordinary and biochemical indices among the various groups of patients were compared

and analyzed by logistic regression.       Results      In DM-HNT groups

the age

fasting blood glucose

HbA1c

blood pressure

and the occurrence of cardiovascular and cerebrovascular complications were higher than those in control group (

P

<

0.01)

TG

TC and LDL-c was significantly higher (

P

<

0.05) but HDL-c was significantly lower when compared with the other 3 groups (

P

<

0.05)

and the duration of diabetes was significantly higher in DM-HNT group compared with DM group (

P

<

0.05). The rates of iliac

femoral

and crural artery atherosclerotic occlusion were 41.4%

72.7%

and 75.6% respectively in DM-HNT group

significantly higher than those in HNT group (27.2%

41.3%

and 28.3% respectively

P

<

0.05) and the control group (19.7%

27.9%

and 16.4% respectively

P

<

0.01). These rates in DM-HNT group was significantly higher than those in DM group (

P

<

0.05)

except the crural artery had no difference (

P

>0.05). Logistic regression analysis showed that systolic blood pressure

LDL

and duration of d

iabetes were independent risk factors in lower extremity atherosclerotic occlusive disease in patients with diabetes.       Conclusion      Compared with the non-diabetic patients

type 2 diabetic patients are more liable to severe vascular lesions in the distal segments of the lower extremity

patients with type 2 diabetes mellitus and hypertension have higher susceptivity to iliac artery and femoral artery atherosclerotic occlusion

and it is associated with high blood pressure

serious disorder of lipid levels

longer duration of diabetes.