Objective      To investigate the expression of chloride intracellular channel 1 (CLIC-1) in colon cancer and its clinical significance.       Methods      Expression of CLIC-1 mRNA and protein were detected by reverse transcription PCR (RT-PCR) and immunohistochemical staining in 54 tissue samples of colon carcinoma and corresponding para-carcinoma tissues collected in our hospital from January to June 2011

respectively. Correlation of CLIC-1 expression and clinicopathologic features was analyzed.       Results      CLIC-1 mRNA and protein expression in colon cancer tissues was signif

icantly higher than that in corresponding para-carcinoma tissues (

P

<

0.05

respectively). Significant differences were found among invasion degree (

P

<

0.05)

lymph node metastasis (

P

<

0.05) and TNM stage (

P

<

0.01) of the patients with CLIC-1 protein expression. However

there was no significant difference among age

sex and size

position and differentiation of the patients with CLIC-1 protein expression (

P

>0.05

respectively).       Conclusion      CLIC-1 is highly expressed in colon cancer

and may play a certain role in progression of colon cancer.