健康青年人血管内皮功能及动脉弹性的MRI测量研究

贾颖; 陈金华; 李雪; 张玉龙; 向建波; 方靖琴; 王舒楠; 张伟国

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健康青年人血管内皮功能及动脉弹性的MRI测量研究

论著 | 更新时间：2025-01-15

- 健康青年人血管内皮功能及动脉弹性的MRI测量研究
- Vascular endothelium functions and arterial flexibility by MRI in health youth: a fundamental study
- 陆军军医大学学报 2011年33卷第22期页码：2417-2420
- 作者机构：
  
  第三军医大学大坪医院野战外科研究所放射科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R322.12;R339.31;R445.2
- 纸质出版日期：2011，
  
  网络出版日期：2011-11-30，
- 稿件说明：
移动端阅览
贾颖, 陈金华, 李雪, 等. 健康青年人血管内皮功能及动脉弹性的MRI测量研究[J]. 陆军军医大学学报, 2011,33(22):2417-2420.

JIA YING, CHEN JINHUA, LI XUE, et al. Vascular endothelium functions and arterial flexibility by MRI in health youth: a fundamental study. [J]. Journal of army medical university, 2011, 33(22): 2417-2420.
贾颖, 陈金华, 李雪, 等. 健康青年人血管内皮功能及动脉弹性的MRI测量研究[J]. 陆军军医大学学报, 2011,33(22):2417-2420. DOI：

JIA YING, CHEN JINHUA, LI XUE, et al. Vascular endothelium functions and arterial flexibility by MRI in health youth: a fundamental study. [J]. Journal of army medical university, 2011, 33(22): 2417-2420. DOI：

摘要

目的评价MRI在测定血管内皮功能及动脉弹性中的作用，探讨各指标正常值参考范围。方法选取26例20～22岁完全健康的男性青年志愿者，利用3.0T MRI的稳态自由进动快速成像(fast imaging with steady state free precession，TureFISP)电影序列扫描，测量动脉内皮依赖性舒张功能(flow-mediated dilation

FMD)及主动脉可扩张性(aortic distensibility

AD)。结果股动脉FMD值为（11.26±2.67）%；升主动脉在心脏收缩末期的最大面积为（600.9±115.7）mm

，心脏舒张末期的最小面积为（449.2±92.3）mm

，AD值为（10.04±3.29）×10

-3

/mmHg；近段降主动脉在心脏收缩末期的最大面积为（369.6±59.8）mm

，心脏舒张末期的最小面积为（287.4±59.7）mm

，AD值为（8.54±4.78）×10

-3

/mmHg；远段降主动脉（distal descending aorta，DDA）在心脏收缩末期的最大面积（310.7±58.1）mm

，心脏舒张末期的最小面积为（221.9±41.2）mm

，AD值为（11.80±4.56）×10

-3

/mmHg。比较股动脉平静状态舒张末期直径及加压后舒张末期直径，差异有统计学意义（

0.01），升主动脉、近段降主动脉、远段降主动脉3组收缩末期的最大面积及舒张末期的最小面积值比较均有显著差异（

0.01）。结论利用MRI测量血管内皮功能及动脉弹性的各项指标，安全、无创、组织分辨力高、重复性好，有利于血管疾病的早期检出，可为临床早期干预治疗提供依据。

Abstract

Objective To evaluate the role of MRI in determining vascular endothelium functions and arterial flexibility and obtain normal reference ranges of each index. M

ethods A total of 26 healthy male young volunteers

aging from 20 to 22

were enrolled in this study. Their flow-mediated dilation (FMD) and aortic distensibility (AD) were measured by 3.0T MRI through using fast imaging with steady state free precession (TureFISP) sequence. Results FMD value of femoral artery was (11.26±2.67)%. The largest area of ascending aorta (AA)

proximal descending aorta (PDA) and distal descending aorta (DDA) in end-systole was (600.9±115.7)

(369.6±59.8) and (310.7±58.1) mm

respectively. The minimum area in end-diastole was (449.2±92.3)

(287.4±59.7) and (221.9±41.2) mm

respectively. The AD value of AA

PDA and DDA was (10.04±3.29)×10

-3

/mmHg

(8.54±4.78)×10

-3

/mmHg and (11.80±4.56)×10

-3

/mmHg

respectively. The femoral artery diameter in end-diastole changed significantly after compression (

0.01). There were markedly difference between the largest area of AA

PDA and DDA in end-systole and the minimum area in end-diastole. Conclusion Using MRI to examine vascular endothelium functions and artery flexibility is a safe

noninvasive and repeatable method

and has high tissue resolution

which could contribute to prophase detection of cardiovascular disease and provide evidence for clinical early treatment.

关键词

核磁共振成像内皮功能动脉弹性

Keywords

MRIvascular endothelium functionarterial flexibility

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