抗C1q抗体及抗ENA抗体与系统性红斑狼疮疾病活动和肾脏受累的关系

凡瞿明; 刘秋月; 张子夏; 张国元; 汪光蓉; 王强; 何兰

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抗C1q抗体及抗ENA抗体与系统性红斑狼疮疾病活动和肾脏受累的关系

论著 | 更新时间：2025-01-15

- 抗C1q抗体及抗ENA抗体与系统性红斑狼疮疾病活动和肾脏受累的关系
- Relationship of anti-C1q antibodies and anti-ENA antibodies with disease activity and nephric impairment in systemic lupus erythematosus
- 陆军军医大学学报 2011年33卷第20期页码：2128-2131
- 作者机构：
  
  川北医学院：附属医院检验科，检验系2005级，检验系
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R593.241;R692;R392.11
- 纸质出版日期：2011，
  
  网络出版日期：2011-10-30，
- 稿件说明：
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凡瞿明, 刘秋月, 张子夏, 等. 抗C1q抗体及抗ENA抗体与系统性红斑狼疮疾病活动和肾脏受累的关系[J]. 陆军军医大学学报, 2011,33(20):2128-2131.

FAN QUMING, LIU QIUYUE, ZHANG ZIXIA, et al. Relationship of anti-C1q antibodies and anti-ENA antibodies with disease activity and nephric impairment in systemic lupus erythematosus. [J]. Journal of army medical university, 2011, 33(20): 2128-2131.
凡瞿明, 刘秋月, 张子夏, 等. 抗C1q抗体及抗ENA抗体与系统性红斑狼疮疾病活动和肾脏受累的关系[J]. 陆军军医大学学报, 2011,33(20):2128-2131. DOI：

FAN QUMING, LIU QIUYUE, ZHANG ZIXIA, et al. Relationship of anti-C1q antibodies and anti-ENA antibodies with disease activity and nephric impairment in systemic lupus erythematosus. [J]. Journal of army medical university, 2011, 33(20): 2128-2131. DOI：

摘要

目的探讨系统性红斑狼疮(systemic lupus erythematosus，SLE)患者血清中抗C1q 抗体及抗ENA抗体与SLE疾病活动状态和肾脏受累的关系，揭示抗C1q 抗体、抗ENA抗体在疾病诊断及评判中的临床价值。方法将来自本院123例SLE患者按疾病活动状态以及是否满足狼疮性肾炎（lupus nephritis

LN）诊断条件分为LN活动组、非LN活动组、LN稳定组和非LN稳定组。患者24 h内收集血、尿标本，分别用ELISA法检测抗C1q抗体；斑点印迹法检测抗ENA抗体；干式化学法检测尿蛋白；用全自动生化分析仪检测血β

微球蛋白（β

-MG）和肌酐（CREA）。结果 β

-MG阳性率：LN活动组与非LN活动组（88.6%

59.4%）、LN稳定组与非LN稳定组（66.1%

47.4%）比较差异有统计学意义(

0.05

0.01）；CREA阳性率：LN稳定组与非LN稳定组相比差异有显著性(27.8%

0.0%

0.01)；尿蛋白“++++” 阳性率：LN活动组(42.9%)与非LN活动组(12.5%)、非LN稳定组(2.6%)比较差异有统计学意义（

0.05，

0.01）；抗C1q抗体阳性率：LN活动组与非LN稳定组相比差异有统计学意义（68.6%

36.8%

0.05）。抗C1q抗体阳性与阴性组间尿蛋白“++++” 、“+”阳性率比较差异有显著性（26.2%

11.3%，14.8%

38.7%，

0.05）。结论 SLE患者肾脏损害常发生于疾病活动期，抗C1q抗体和部分抗ENA抗体可能是加重肾脏损害的因素。实验室监测抗C1q抗体及β

-MG的水平对预测SLE患者肾脏损害有积极指导意义。

Abstract

Objective To investigate the relation

ship of serum anti-C1q antibodies and anti-extractable nuclear antigen (anti-ENA) antibodies with disease activity and nephric impairment in systemic lupus erythematosus (SLE) for clinical values of the 2 antibodies in diagnosis and evaluation of the disease. Methods A total of 123 cases of SLE patients who admitted in our hospital in recent 1 year were divided into 4 groups according to SLE activity and lupus nephritis (LN)

that is

LN activity group (

=35); non-LN activity group(

=32); LN stable group (

=18) and non-LN stable group (

=38). Serum and urine specimens of SLE patients was collected within 24 h of first hospitalization. Anti-C1q antibodies were detected by ELISA

and anti-ENA antibodies were assayed by dot blotting. Dry chemistry method was used to detect urinary protein. β

-microglobulin (β

-MG) and creatinine (CREA) was assayed using the automatic biochemical analyzer. Results β

-MG positive rate in LN activity group （88.6%） was significantly higher than non-LN activity group（59.4%）and LN stable group（66.1%）(both

0.05)

and was still significantly higher than non-LN stable group（47.4%）(

0.01). The positive rate of CREA in stable group of LN （27.8%）was significantly higher than stable group of non-LN（0.0%）（

0.01). Urine protein characterized as “++++” positive rate in LN activity group（42.9%）was significantly higher than non-LN activity group（12.5%）and non-LN stable group（2.6%）(

0.05

0.01). Anti-C1q antibody positive rate was significantly higher in LN activity group (68.8%) than in non-LN stable group (36.8%)(

0.05). Significant differences were found in urinary protein as a “++++” and “+” positive rate in anti-C1q antibody-negative group and the anti-C1q antibody positive group (26.2%

11.3%，14.8%

38.7%，

0.05). Conclusion In SLE patients

nephric impairment occur when disease in activity

. Presence of anti-C1q antibodies and anti-ENA antibodies may aggravate the impairment. And to those patients

standard monitoring of anti-C1q antibodies and β

-MG is of significance to forecast the kidney damage.

关键词

C1q，抗体系统性红斑狼疮狼疮肾炎

Keywords

C1q，antibodysystemic lupus erythematosuslupus nephritis

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