Objective      To determine the effects of atorvastatin on the translocation of NF-κB p65 into the nuclear induced by LPS in abdominal macrophage isolated from apolipoprotein E knockout (ApoE

-/-

) mouse.       Methods      Abdominal macrophage were isolated and purified from ApoE

-/-

mouse

and then cultivated

and treated by atorvastatin (10 μmol/L)

LPS (10 ng/ml)

and atorvastatin (1

5 and 10 μmol/L) combined with LPS treatment. The nuclear translocation of NF-κB p65 was observed by laser scanning confocal microscopy and Western blotting

while the IL-6 levels in culture supernatants was measured by ELASA.       Results      Laser scanning confocal microscopy and Western blotting showed that TRITC-labeled NF-κB p65 was mainly located in the plasma of macrophage and mildly expressed in the nuclear in atorvastatin group (3.71±0.26)

but was mainly located in the nuclei and strongly expressed in LPS group (16.12±1.28

P

<

0.05). When macrophage were cultivated and induced by LPS and different concentrations atorvastatin

NF-κB p65 was expressed in the nuclear in a negative dose-dependent manner (10.95±0.71

7.61±0.73

and 4.56±0.39

respectively

P

<

0.05). At the same time

the IL-6 levels in culture supernatants was also reduced in a negative dose-dependent manner in atorvastatin intervention groups（

P

<

0.05）.       Conclusion      Atorvastatin inhibits the nuclear translocation of NF-κB p65 and secretion of inflammatory mediators IL-6 in abdominal macrophage of ApoE

-/-

mouse induced by LPS.