补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响

丁一; 杨恒; 文钦

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补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响

论著 | 更新时间：2025-01-15

- 补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响
- Effects of Bushen Guchi Bolus on alveolar bone reconstruction of periodontitis rats 
- 陆军军医大学学报 2011年33卷第22期页码：2390-2393
- 作者机构：
  
  1. 四川大学华西口腔医院牙周科
  2. 重庆医科大学附属口腔医院牙周粘膜科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R781.42;R780.2;R289.5
- 纸质出版日期：2011，
  
  网络出版日期：2011-11-30，
- 稿件说明：
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丁一, 杨恒, 文钦. 补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响[J]. 陆军军医大学学报, 2011,33(22):2390-2393.

DING YI, YANG HENG, WEN QIN. Effects of Bushen Guchi Bolus on alveolar bone reconstruction of periodontitis rats . [J]. Journal of army medical university, 2011, 33(22): 2390-2393.
丁一, 杨恒, 文钦. 补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响[J]. 陆军军医大学学报, 2011,33(22):2390-2393. DOI：

DING YI, YANG HENG, WEN QIN. Effects of Bushen Guchi Bolus on alveolar bone reconstruction of periodontitis rats . [J]. Journal of army medical university, 2011, 33(22): 2390-2393. DOI：

摘要

目的研究补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响，进一步探讨补肾固齿丸对牙周炎的治疗机制。方法成功建立大鼠牙周炎模型之后，大鼠分为正常组、牙周炎模型组、补肾固齿丸组，给予补肾固齿丸治疗，采用放射免疫法测定血清骨钙蛋白与Ⅰ型胶原交联C端肽浓度，同时采用显微CT对大鼠牙槽骨进行三维重建，以评价补肾固齿丸对大鼠实验性牙周炎牙槽骨修复重建的影响。结果经过补肾固齿丸治疗1个月后，补肾固齿丸组血清骨钙蛋白与Ⅰ型胶原交联C端肽浓度[分别为（0.859 1±0.156 9）、（2.038 6±0.407 5）

]

较牙周炎模型组[分别为（1.806 4±0.258 5）、（3.056 0±0.461 5）

]

下降（

0.05）。补肾固齿丸组大鼠牙槽骨的骨小梁体积分数（0.304 1±0.010 0）明显高于牙周炎模型组[（0.181 6±0.020 0），

0.05

]

，且骨小梁数量（3.124 4±0.100 0）略高于牙周炎模型组[（2.088 9±0.200 0），

>0.05

]

，而补肾固齿丸组的骨小梁分离度（0.575 1±0.020 0）较牙周炎模型组（0.611 0±0.030 0）有降低的趋势（

0.05）。结论补肾固齿丸能改善牙周炎大鼠牙槽骨代谢状况，促进牙槽骨改建，对牙周炎具有一定的辅助治疗作用。

Abstract

Objective To explore the influence of Bushen Guchi Bolus on the alveolar bone reconstruction of rats with experimental periodontitis

and to investigate the treatment mechanism of the drug. Methods The model of experimental periodontitis were established by means of steel wire

high-carbohydrate diet and periopathogens inoculation in rats. Then Bushen Guchi Bolus was given to rats of treatment group at a

dose of 0.8 g/(kg·d) by gastric injection for 30 d

and 10 ml/(kg·d) normal saline was give to rats of normal control and model group for same period. All rats were killed at then end of treatment. The contents of osteocalcin (OCN) and pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) in the serum were observed by radioimmunoassay (RIA). Micro-CT and software digitized specimens were reconstructed three-dimensionally for parameter assessment of alveolar bone (including bone volume /total volume

trabecular number

and trabecular separation). Results Rat experimental periodontitis models were successfully established by steel wire

high-carbohydrate diet and periopathogens inoculation. After 30 days’ treatment of Bushen Guchi Bolus

the level of OCN and ICTP in the serum were decreased in treatment group (0.859 1±0.156 9 and 2.038 6±0.407 5

0.05)

compared with model control group (1.806 4±0.258 5 and 3.056 0±0.461 5). After treatment

BV/TV of alveolar bone had distinct improvement (0.304 1±0.010 0

0.05)

and Tb.N showed a trend of increase in the treatment group (3.124 4±0.100 0

>0.05). In addition

Tb.Sp in the treatment group (0.575 1±0.020 0) was inferior to that of the model group （0.611 0±0.030 00

0.05）. Conclusion Bushen Guchi Bolus improves alveolar bone reconstruction of rats with experimental periodontitis.

关键词

补肾固齿丸大鼠实验性牙周炎显微CT

Keywords

Bushen Guchi Bolusratsexperimental periodontitismicro-CT

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