Objective      To evaluate the clinical efficiency of intervention with bronchofiberoscopy in treatment of muti-drug resistant pulmonary tuberculosis.       Methods      Sixty-three patients with identified multi-drug resistant pulmonary tuberculosis in our department from 2007 to 2009 were randomly divided into experiment group (

n

=31) and control group (

n

=32). The experiment group was treated by bronchial lavage with bronchofiberoscopy once per 2 weeks for 9 to 15 times and general anti-tuberculotic treatment

and the control group only received the later treatment. Sputum smear examination

chest X-ray filming/CT scanning

and liver and renal function were carried out.        Results

      At the end of treatment

the symptoms (such as cough and haemoptysis) were greatly improved

the sputum negative conversion was 87.0%

the foci absorption was 83.8%

and cavity close was 74.1%in the experiment group

with the later 3 parameters significantly higher than those of control group (59.3%

56.2% and 40.6%

P

<

0.05). There were liver dysfunction in 3 cases of experiment group and 7 cases of control group. They all recovered after routine treatment with hepato-protective and transaminase-descending drugs.       Conclusion      Bronchial lavage with bronchofiberoscopy combined with chemotherapy exerts significant effect in the treatment of multi-drug resistant pulmonary tuberculosis

superior to chemotherapy alone.