新型载氧超声微泡的制备及其基本特性研究

肖欢; 唐毅; 杨春江; 李攀; 高洋; 李奇林

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新型载氧超声微泡的制备及其基本特性研究

论著 | 更新时间：2025-01-15

- 新型载氧超声微泡的制备及其基本特性研究
- Preparation of a new type of ultrasound microbubble loaded with oxygen and its basic characteristics
- 陆军军医大学学报 2013年35卷第17期页码：1809-1812
- 作者机构：
  
  1. 重庆医科大学附属儿童医院超声科，儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆市儿童发育重大疾病诊治与预防国际科技合作基地
  2. 重庆医科大学附属第二医院超声影像学研究所
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R943;R445.1;R977.6
- 纸质出版日期：2013，
  
  网络出版日期：2013-09-15，
- 稿件说明：
移动端阅览
肖欢, 唐毅, 杨春江, 等. 新型载氧超声微泡的制备及其基本特性研究[J]. 陆军军医大学学报, 2013,35(17):1809-1812.

XIAO HUAN, TANG YI, YANG CHUNJIANG, et al. Preparation of a new type of ultrasound microbubble loaded with oxygen and its basic characteristics. [J]. Journal of army medical university, 2013, 35(17): 1809-1812.
肖欢, 唐毅, 杨春江, 等. 新型载氧超声微泡的制备及其基本特性研究[J]. 陆军军医大学学报, 2013,35(17):1809-1812. DOI：

XIAO HUAN, TANG YI, YANG CHUNJIANG, et al. Preparation of a new type of ultrasound microbubble loaded with oxygen and its basic characteristics. [J]. Journal of army medical university, 2013, 35(17): 1809-1812. DOI：

摘要

目的制备一种新型的载氧脂质微泡并考察其基本特性。方法采用机械振荡法制备高效载氧的脂质微泡，考察微泡形态、浓度、平均粒径和zeta电位情况，并观察其随时间变化及经

Co射线灭菌后情况。将微泡加入缺氧溶液，比较超声辐照前后(5 kHz、3.5 W)溶液中溶解氧浓度（dissolved oxygen，DO）的变化，并评价微泡增强兔肝超声显影的效果。结果自制载氧脂质微泡平均粒径约为（959.7±161.2）nm，粒径分布均匀，浓度约为（4.01±0.69）×10

/mL，zeta电位为-（12.9±2.4）mV；在观察时间内（7 d）及

Co 射线灭菌前后，微泡形态，粒径大小、浓度及zeta电位无明显变化（

>0.05）；经超声辐照后，缺氧溶液溶解氧浓度明显升高；载氧脂质微泡可明显增强兔肝实质超声显影。结论自制载氧脂质微泡性能稳定，具有较好的携氧、释氧能力，并可作为一种新型的理想超声造影剂。

Abstract

Objective To prepare a new type of lipid-coated ultrasound microbubble loaded with oxygen

and to study its basic characteristics. Methods A new type of ultrasound microbubble carrying oxygen was prepared by mechanic vibration. The appearance

concentration

mean diameter and zeta potential of the oxygen-loaded microbubbles were investigated

and their changes within 7 d and after

Co ray irradiation were observed. The microbubbles were mixed with oxygen-deprived solution and the dissolved oxygen (DO) concentration was compared before and after

ultrasound irradiation (5 kHz

3.5 W). The enhancing effect of ultrasound imaging on rabbit liver was evaluated after the microbubble injection. Results The oxygen-loaded microbubbles appeared as a uniform size with a mean diameter of 959.7±161.2 nm

concentration of (4.01±0.69) ×10

/mL and zeta potential of -(12.9±2.4)mV. Their appearance

concentration

mean diameter and zeta potential didn′t change within 7 d or after radiosterilization of

Co ray (

>0.05). The DO concentration of the solution significantly increased after ultrasound irradiation. The ultrasound imaging on rabbit liver was greatly enhanced after oxygen-loaded microbubble injection. Conclusion The new type of self-made lipid-coated oxygen-loaded microbubble has stable performance and good capacity of carrying and releasing oxygen

and it can be used as a novel and ideal ultrasound contrast agent.

关键词

氧气微泡脂质体载体兔

Keywords

oxygenmicrobubblelipidcarrierrabbits

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