Objective       To determine the effect of kaempferol on experimental hyperlipemia and hemorheological parameters in rats

and compare the effect with that of lindley euqatorium herb total flavonoid.        Methods        A total of 70 SD rats were randomly and equally divided into 7 groups

that is

blank control

hyperlipemia group

high- and low-dosed kaempferol groups

high- and low-dosed total f

lavonoid groups

and positive drug group (fenofibrate). The rats of the later 6 groups were fed with high-fat food for 6 weeks

and those of the treatment groups were given oral administration of 300 and 100 mg/kg kaempferol

100 and 50 mg/kg crude total flavonoids

and 20 mg/kg fenofibrate respectively. After 6 weeks

all experimental rats were killed

and the serum levels of blood lipids and hemorheological parameters

the activity of SOD

the content of MDA were detected. Oil red O staining was employed to observe the effects of kaemferol on oxLDL-induced macrophage foam cell formation.       Results       Kaempferol decreased the serum levels of blood lipids and hemorheological parameters

blood viscosity

and serum content of MDA

but increased the activity of SOD when compared with hyperlipemia group (

P

<

0.01). There was no obvious difference in above indexes between the high- and low-dosed total flavonoid groups (

P

>0.05). Kaempferol effectively inhibited oxLDL-induced lipid aggregation within macrophages.       Conclusion        Consecutive treatment of kaempferol decreases blood lipids

hemorheological parameters

and MDA content

but improves SOD activity. Kaempferol also inhibits the formation of macrophage foam cells. Kaempferol might substitute for lindley euqatorium herb total flavonoid in decreasing blood lipids and anti-inflammation in clinical practice.