Objective        To determine the influencing factors of medication compliance of outpatients with first episode depression.       Methods        One hundred and fifty outpatients with first episode depression in our department from March 2011 to March 2013 were recruited in this study. The investigation was carried out with questionnaires

including general conditions

understanding and att

itude of disease

treatment compliance evaluation

perceived social support scale

and Cattell-16 personality factor questionnaire. The obtained data were analyzed by

Chi

- square test

student’s 

t

test and multivariate logistic regression analysis for the relationship of above indexes with medication compliance within the first month.       Results         Good compliance group had statistical differences in the family monthly income

recognition of diagnosis

stigma

understanding of the disease

worry about side effects of drugs

social support score and 16PF personality including stability

sensitivity

perseverance and anxiety when compared with poor compliance group (

P

<

0.05). Logistic regression analysis showed that odds ratio (

OR

) value of social support

the family monthly income

stigma

worry about side effects of drugs

understanding disease knowledge

recognition of diagnosis

perseverance

sensitivity

and anxiety were 9.523

6.088

5.368

4.237

3.213

2.519

2.246

0.532

and 0.207 respectively.       Conclusion         Many important influencing factors affect drug compliance in depressive patients. Family monthly income

diagnosis recognition

stigma

understanding of disease

social support

worry about side effects of drugs and personality can predict patient compliance in those with first episode depression.