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1.江西中医药大学中医基础理论分化发展研究中心/江西省中医病因生物学重点实验室,南昌 330004
2.江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
彭淑红,Email:yaomoon@126.com,研究方向:中医药防治代谢性疾病。
朱卫丰,Email:zwf0322@126.com。
收稿:2026-02-09,
修回:2026-03-14,
录用:2026-03-26,
网络首发:2026-06-10,
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彭淑红, 张蒙雨, 姜家旺, 等. 甘油激酶与甘油转运蛋白在肥胖和糖尿病肝脏和脂肪组织中表达变化的研究进展[J/OL]. 重庆医科大学学报, 2026,1-6.
Peng Shuhong,Zhang Mengyu,Jiang Jiawang,et al.Research progress on expression changes of glycerol kinase and aquaglyceroporins in the liver and adipose tissue of obesity and diabetes[J].Journal of Chongqing Medical University,
彭淑红, 张蒙雨, 姜家旺, 等. 甘油激酶与甘油转运蛋白在肥胖和糖尿病肝脏和脂肪组织中表达变化的研究进展[J/OL]. 重庆医科大学学报, 2026,1-6. DOI:
Peng Shuhong,Zhang Mengyu,Jiang Jiawang,et al.Research progress on expression changes of glycerol kinase and aquaglyceroporins in the liver and adipose tissue of obesity and diabetes[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
目前,肥胖与糖尿病(diabetes mellitus,DM)的患病率持续上升,脂质代谢紊乱是两者的典型特征,常伴循环甘油水平升高。甘油作为糖异生的重要前体,其在体内的水平主要受甘油激酶(glycerol kinase,GK)和水甘油通道蛋白(aquaglyceroporins,AQPs)的调控。脂肪组织与肝脏分别是机体甘油生成和利用的主要场所。GK参与甘油的分解代谢,其在肝脏和脂肪组织中的表达模式不同。水甘油通道蛋白7(aquaglyceroporin 7,AQP7)和水甘油通道蛋白9(aquaglyceroporin 9,AQP9)分别是脂肪组织和肝脏中主要表达的AQPs,脂肪组织中的AQP7负责甘油的外排,而肝脏中的AQP9负责甘油的摄取,以便在肝脏丰富的GK催化下进一步代谢。在肥胖和DM状态下,GK与AQPs表达异常,这种异常与机体甘油水平的变化密切相关。本文系统梳理肥胖及DM状态下肝脏和脂肪组织GK与AQPs的表达变化,从而为解释代谢性疾病中甘油水平异常提供理论参考,并为肥胖和DM的治疗提供潜在靶点。
Recently,there have been constant increases in the prevalence of obesity and diabetes mellitus,and lipid metabolism disorders are the characteristic features of these two diseases,which are often accompanied by an increase in circulating glycerol. Glycerol,an important precursor for gluconeogenesis,is mainly regulated by glycerol kinase(GK) and aquaglyceroporins(AQPs) in the body. Adipose tissue is the primary site for glycerol production,while the liver is the primary site for glycerol utilization. GK is involved in the catabolism of glycerol,with different expression patterns in the liver and adipose tissue. Aquaglyceroporin 7(AQP7) and aquaglyceroporin 9(AQP9) are the main aquaglyceroporins expressed in adipose tissue and the liver,respectively. AQP7 mediates glycerol efflux in adipose tissue,and AQP9 mediates the uptake of glycerol for further metabolism catalyzed by abundant GK in the liver. Abnormal expression of GK and AQPs is observed in obesity and diabetes,and such abnormalities are closely associated with changes in glycerol levels in the body. This article systematically reviews the changes in the expression of GK and AQPs in the liver and adipose tissue under the conditions of obesity and diabetes,in order to provide a theoretical basis for explaining abnormal glycerol level in metabolic diseases,as well as for identifying potential targets for the treatment of obesity and diabetes.
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