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1.黑龙江中医药大学第一临床医学院,哈尔滨 150006
2.黑龙江中医药大学附属第一医院妇科二科,哈尔滨 150006
陈思圻,Email:2038513756@qq.com,研究方向:中医妇科。
冯晓玲,Email:doctorfengmen@163.com。
收稿:2025-08-22,
修回:2026-01-06,
录用:2026-01-06,
纸质出版:2026-01-15
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陈思圻, 陶爱琳, 冯晓玲. 中药通过调控NF-κB通路治疗复发性流产研究进展[J/OL]. 重庆医科大学学报, 2026,1-9.
Chen Siqi,Tao Ailin,Feng Xiaoling.Research advances in traditional Chinese medicine for treatment of recurrent spontaneous abortion by regulating the nuclear factor-kappa B pathway[J].Journal of Chongqing Medical University,
陈思圻, 陶爱琳, 冯晓玲. 中药通过调控NF-κB通路治疗复发性流产研究进展[J/OL]. 重庆医科大学学报, 2026,1-9. DOI:
Chen Siqi,Tao Ailin,Feng Xiaoling.Research advances in traditional Chinese medicine for treatment of recurrent spontaneous abortion by regulating the nuclear factor-kappa B pathway[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
复发性流产(recurrent spontaneous abortion,RSA)是一种常见的不良妊娠结局。核因子κB(nuclear factor kappa B,NF-κB)在其中发挥关键作用。近年来,中药在干预RSA方面表现出独特优势,尤其是在调控NF-κB通路及相关机制中展现了显著效果。本文围绕NF-κB通路及其激活机制,综述了该通路在RSA中调控炎症反应、氧化应激及血管生成的作用,发现中药单体及复方可靶向NF-κB相关通路,通过调控炎症失衡、减轻氧化应激、改善血管生成与螺旋动脉重塑,从而改善RSA的妊娠结局。本文旨在为中医药通过调控NF-κB通路治疗RSA提供理论参考,并为相关新药研发与临床应用提供思路。
Recurrent spontaneous abortion(RSA) is a common adverse pregnancy outcome,and nuclear factor-kappa B(NF-κB) plays a key role in this process. In recent years,traditional Chinese medicine(TCM) has shown unique advantages in the intervention of RSA,especially in the regulation of the NF-κB pathway and related mechanisms. Focusing on the NF-κB pathway and its main activation mechanism,this article summarizes the mechanism of NF-κB in the regulation of inflammatory response,oxidative stress,and angiogenesis in RSA,and it is found that TCM monomers and compound prescriptions can target NF-κB-related pathways,reduce excessive oxidative stress,and improve angiogenesis and spiral artery remodeling by regulating unbalanced inflammatory response,thereby effectively improving the pregnancy outcome of RSA. This article lays the theoretical foundation for TCM treatment of RSA by regulating the NF-κB pathway and provides a reference for the development and clinical application of new drugs.
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